INT11150

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 9.01
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlst) plasma membrane (Dlst) nucleus (Dlst)
transferase activity, transferring acyl groups (Dlst) cytoplasm (Dlst)
Anatomy Link Frequency
body 5
plasma 4
peritoneum 4
left ovary 2
uterus 2
Dlst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 130 100.00 Very High Very High Very High
depression 1 99.76 Very High Very High Very High
gABA 16 99.60 Very High Very High Very High
Snapping jaw 13 99.54 Very High Very High Very High
Nicotine 1 99.54 Very High Very High Very High
agonist 19 99.34 Very High Very High Very High
Morphine 128 98.56 Very High Very High Very High
Dopamine 9 94.96 High High
endometriosis 336 92.96 High High
anesthesia 54 91.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 129 100.00 Very High Very High Very High
Body Weight 66 100.00 Very High Very High Very High
Depression 3 99.76 Very High Very High Very High
Endometriosis 448 99.62 Very High Very High Very High
Temporomandibular Joint Syndrome 13 99.54 Very High Very High Very High
Pressure And Volume Under Development 5 99.16 Very High Very High Very High
Cognitive Disorder 8 96.74 Very High Very High Very High
Cancer 69 96.40 Very High Very High Very High
Apoptosis 11 95.04 Very High Very High Very High
Decapitation 24 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another possibility is that perforating the left side of the peritoneum results in an increase release of ovarian gamma amino butyric acid (GABA), and a subsequent increase of E2 concentrations.
Positive_regulation (increase) of E2 in peritoneum associated with gaba
1) Confidence 0.51 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.05 Pain Relevance 0.19
In addition, the electrochemical stimulation in proestrus day of the medial basal pre-chiasmatic area of untreated rats increased E2 and P4 concentrations in serum.
Positive_regulation (increased) of E2 in medial
2) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.14
Perforating the right side of the peritoneum on D2 day resulted in E2 concentration increases (184%), while perforating the left side resulted in a decrease (51%) of E2 serum concentrations.
Positive_regulation (increases) of E2 in peritoneum
3) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.21
Plasma E2 levels in animals treated with E2-CDS were slightly increased to 13 pg/ml for single-injected and to 44 pg/ml for multiple-injected rats.
Positive_regulation (increased) of E2 in Plasma
4) Confidence 0.42 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.57 Pain Relevance 0.19
Since P4 and androgens are precursors in the synthesis of E2, we presume that this mechanism may explain the increase in E2 serum concentrations observed in rats with peritoneum perforation previously injected with ATR.
Positive_regulation (increase) of E2 in peritoneum
5) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.20 Pain Relevance 0.09
Also, mammary gland proliferation was increased under both E2 and GEN.
Positive_regulation (increased) of E2 in mammary gland
6) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.12 Pain Relevance 0
ULO rats treated with ATR on D2 or P, resulted in an asymmetrical E2 secretion response; when the right ovary remained in situ an increase in E2 was observed, and a decrease when the left ovary remained in situ.
Positive_regulation (response) of E2 in left ovary
7) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
Blocking the cholinergic system of rats with left side peritoneum perforation on D1 or P resulted in a drop in E2 serum concentrations (52%; 47%, respectively), while the same treatment performed on D2 resulted in a significant E2 concentrations increase (157%).
Positive_regulation (increase) of E2 in peritoneum
8) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
According to Erdö, et. al. [25] and Laszlo, et. al. [26], injecting GABA into pseudo-pregnant rats increases E2 concentration in the blood.
Positive_regulation (increases) of E2 in blood associated with gaba
9) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.16
The response of FSH to E2 and the interaction between E2 and morphine on FSH secretion were similar to those observed for LH, albeit lower in magnitude.
Positive_regulation (response) of E2 associated with morphine
10) Confidence 0.32 Published 1987 Journal Endocrinology Section Abstract Doc Link 3032570 Disease Relevance 0 Pain Relevance 0.59
ULO rats treated with ATR on D2 or P, resulted in an asymmetrical E2 secretion response; when the right ovary remained in situ an increase in E2 was observed, and a decrease when the left ovary remained in situ.
Positive_regulation (increase) of E2 in left ovary
11) Confidence 0.30 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
Rats were treated with cholinergic agonists (nicotine + oxotremorine) which induced adrenomedullary E2 and E3 + E4 transcripts (5- and 80-fold, respectively).
Positive_regulation (induced) of E2 associated with nicotine and agonist
12) Confidence 0.28 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1537835 Disease Relevance 0.25 Pain Relevance 0.19
Stimulation of PR in mammary epithelial cells is another typical effect of E2, which we observed in the animals treated with both E2 doses and GEN high; however, we counted significantly fewer PR-expressing cells in the E2 high tissues compared with the E2 low tissues.
Positive_regulation (effect) of E2 in epithelial cells
13) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.17 Pain Relevance 0
Chronic exposure (4 days) to morphine enhanced both the inhibitory effects of E2 on LH secretion at 1000 h and E2 induction of the midafternoon surge in LH.
Positive_regulation (induction) of E2 associated with morphine
14) Confidence 0.26 Published 1987 Journal Endocrinology Section Abstract Doc Link 3032570 Disease Relevance 0 Pain Relevance 0.55
Gonadectomy reduced plasma testosterone and dihydrotestosterone (DHT) levels compared to intact rats, while subsequent estradiol (E2) or DHT treatment increased plasma E2 and DHT levels, respectively.
Positive_regulation (increased) of E2 in plasma
15) Confidence 0.25 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8361335 Disease Relevance 0 Pain Relevance 0.13
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (free) of E2 in body associated with body weight
16) Confidence 0.24 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.25 Pain Relevance 0.09
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (follows) of E2 in body associated with body weight
17) Confidence 0.24 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.25 Pain Relevance 0.09
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (free) of E2 in body associated with body weight
18) Confidence 0.24 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.25 Pain Relevance 0.09
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (free) of E2 in body associated with body weight
19) Confidence 0.24 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.24 Pain Relevance 0.08
These results suggest that chronic high circulating E2 levels result in a depression of TIDA neuronal activity which is sustained after E2 is removed.
Positive_regulation (result) of E2 in neuronal associated with depression
20) Confidence 0.21 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3945627 Disease Relevance 0.10 Pain Relevance 0.67

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