INT111504

Context Info Confidence 0.01 First Reported 2003 Last Reported 2003 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.96

extracellular space (Ptprg) extracellular region (Pnoc)

Anatomy Link Frequency brain 2 Pnoc (Rattus norvegicus) Ptprg (Rattus norvegicus)

Pain Link Frequency Relevance Heat orphanin 4 100.00 agonist 2 98.68 Endogenous opioid 2 97.52 Analgesic 4 80.88 Opioid 2 76.56 opioid receptor 4 75.00 narcan 4 59.52 mu opioid receptor 8 49.76

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Utilizing agonist-stimulated GTPgammaS autoradiography, we analyzed the ability of preproorphanin FQ (ppOFQ) peptides to stimulate [35S]-GTPgammaS binding in adult rat brain.

preproorphanin FQ Positive_regulation (stimulate) of GTPgammaS Spec (analyzed) Binding (binding) of in brain associated with agonist

1) Confidence 0.01 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12842269 Disease Relevance 0 Pain Relevance 0.47

Orphanin FQ (OFQ) stimulated [35S]-GTPgammaS binding in a pattern similar to that described for [125I]-OFQ at the endogenous opioid receptor-like (ORL1) receptor.

Orphanin FQ Positive_regulation (stimulated) of GTPgammaS Binding (binding) of associated with orphanin and endogenous opioid

2) Confidence 0.01 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12842269 Disease Relevance 0 Pain Relevance 0.50

General Comments

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