INT111512

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 6.45
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Galr1) plasma membrane (Galr1) signal transducer activity (Galr1)
Anatomy Link Frequency
neuronal 2
Galr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 76 100.00 Very High Very High Very High
Locus ceruleus 4 99.78 Very High Very High Very High
Ventral tegmentum 4 99.68 Very High Very High Very High
Nucleus accumbens 4 99.62 Very High Very High Very High
Substantia nigra 4 99.54 Very High Very High Very High
c fibre 2 99.46 Very High Very High Very High
intrathecal 5 99.34 Very High Very High Very High
Antinociceptive 4 99.12 Very High Very High Very High
narcan 2 97.64 Very High Very High Very High
Morphine 1 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 320 99.48 Very High Very High Very High
Death 200 98.64 Very High Very High Very High
Nociception 3 97.98 Very High Very High Very High
Targeted Disruption 61 97.52 Very High Very High Very High
Status Epilepticus 35 96.08 Very High Very High Very High
Sprains And Strains 60 93.80 High High
INFLAMMATION 6 92.76 High High
Drug Dependence 1 92.24 High High
Injury 45 91.24 High High
Drug Induced Neurotoxicity 5 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologic inhibition of GalR1 exacerbates seizure-induced cell death
Negative_regulation (inhibition) of GalR1 associated with convulsion and death
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0.98 Pain Relevance 0.17
This study demonstrates that deficiency of GalR1 exacerbates KA-induced excitotoxicity and identifies GalR1 as a target contributing to seizure-induced cell death in vivo.
Negative_regulation (deficiency) of GalR1 associated with convulsion and death
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.06 Pain Relevance 0.14
In the present study, we report that reduction of GalR1 mRNA via null mutation or injection of the GalR1 antagonist, galantide, prior to kainate-induced status epilepticus induces hippocampal damage in a mouse strain known to be highly resistant to kainate-induced neuronal injury.
Negative_regulation (reduction) of GalR1 in neuronal associated with antagonist, injury, status epilepticus and sprains and strains
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001489 Disease Relevance 1.16 Pain Relevance 0.19
Our results demonstrate that deficiency of GalR1 exacerbates seizure-induced neuronal death after KA-induced excitotoxicity in the brain.
Negative_regulation (deficiency) of GalR1 in neuronal associated with convulsion and death
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.24 Pain Relevance 0.19
As an alternative approach to the use of knockout (KO) mice, we also utilized intra-hippocampal pre-treatment administration of a GalR1 antagonist to determine if pharmacologic inhibition of GalR1 could modulate susceptibility to seizure-induced cell death.
Negative_regulation (inhibition) of GalR1 associated with targeted disruption, convulsion, antagonist and death
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.21 Pain Relevance 0.27
This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor.
Negative_regulation (lack) of galanin-R1 receptor associated with nociception and c fibre
6) Confidence 0.43 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12842279 Disease Relevance 0.16 Pain Relevance 0.30
All three galanin receptors are found in the VTA, SN, NA, and LC; however, GalR1 protein is most highly represented in the VTA, NA, and SN, suggesting that GalR1 may play a predominant role in galanin-mediated regulation of dopamine neurotransmission.
Negative_regulation (represented) of GalR1 associated with nucleus accumbens, ventral tegmentum, dopamine, locus ceruleus and substantia nigra
7) Confidence 0.42 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.09 Pain Relevance 1.02
Furthermore, intrathecal administration of galantide, an antagonist of galanin receptor, could attenuate the antinociceptive effect induced by intraperitoneal injection of morphine, suggesting an involvement of opioid systems in the galanin-induced antinociception.
Negative_regulation (antagonist) of galanin receptor associated with antinociception, antagonist, opioid, antinociceptive, morphine and intrathecal
8) Confidence 0.40 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 16214241 Disease Relevance 0.56 Pain Relevance 1.32

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