INT111514

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 15.13
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
plasma 8
liver 8
spinal cords 4
macrophage 2
PGE2 2
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 36 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
ischemia 19 99.46 Very High Very High Very High
Inflammation 60 99.08 Very High Very High Very High
narcan 8 98.62 Very High Very High Very High
Calcitonin gene-related peptide 6 97.64 Very High Very High Very High
Angina 7 97.16 Very High Very High Very High
antagonist 2 94.96 High High
Opioid 1 94.52 High High
anesthesia 8 93.08 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 109 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Pressure And Volume Under Development 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Frailty 9 99.92 Very High Very High Very High
Multiple Sclerosis 132 99.56 Very High Very High Very High
Cardiovascular Disease 6 99.52 Very High Very High Very High
Cv General 4 Under Development 2 99.46 Very High Very High Very High
Hyperplasia 5 99.26 Very High Very High Very High
Apoptosis 3 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I/R significantly increased NADPH oxidase activity, H(2)O(2) production, and myeloperoxidase (MPO) activity.
Positive_regulation (increased) of Gene_expression (production) of MPO associated with urological neuroanatomy
1) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19942802 Disease Relevance 0.46 Pain Relevance 0.27
I/R significantly increased NADPH oxidase activity, H(2)O(2) production, and myeloperoxidase (MPO) activity.
Positive_regulation (increased) of Gene_expression (production) of myeloperoxidase associated with urological neuroanatomy
2) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19942802 Disease Relevance 0.46 Pain Relevance 0.27
Heparin, which is known to increase MPO plasma levels in patients with stable CAD, had no effect on MPO plasma levels in AMI patients.
Positive_regulation (increase) of Gene_expression (levels) of MPO in plasma associated with coronary artery disease, urological neuroanatomy and myocardial infarction
3) Confidence 0.46 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 1.91 Pain Relevance 0.09
Increased expression and plasma levels of myeloperoxidase are closely related to the presence of angiographically-detected complex lesion morphology in unstable angina.
Positive_regulation (Increased) of Gene_expression (expression) of myeloperoxidase in plasma associated with angina
4) Confidence 0.46 Published 2010 Journal Heart Section Title Doc Link 20956487 Disease Relevance 0.10 Pain Relevance 0.10
Moreover, MPO level is significantly higher in patients with unstable coronary artery disease and myocardial infarction compared with healthy subjects and patients with stable angina.
Positive_regulation (higher) of Gene_expression (level) of MPO in coronary artery associated with angina, cardiovascular disease, urological neuroanatomy and myocardial infarction
5) Confidence 0.46 Published 2010 Journal Int J Lab Hematol Section Abstract Doc Link 20201999 Disease Relevance 1.14 Pain Relevance 0.13
Hepatic MPO was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [18].
Positive_regulation (increase) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy
6) Confidence 0.46 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.37 Pain Relevance 0
Hepatic MPO was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [18].
Positive_regulation (recovery) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy
7) Confidence 0.46 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.37 Pain Relevance 0
MPO present in liver tissues was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [16].
Positive_regulation (increase) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy
8) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.44 Pain Relevance 0
MPO present in liver tissues was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [16].
Positive_regulation (recovery) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy
9) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.44 Pain Relevance 0
CONCLUSIONS: In stable angina patients, coronary stenting is associated with an acute and transient increase in plasma MPO levels, but not in lactoferrin levels, with an enhanced response in the presence of complex lesions.
Neg (not) Positive_regulation (increase) of Gene_expression (levels) of MPO in plasma
10) Confidence 0.44 Published 2009 Journal Eur. J. Intern. Med. Section Body Doc Link 19712859 Disease Relevance 0.18 Pain Relevance 0
Oxytocin treatment significantly reversed the I/R-induced elevations in serum transaminase and TNF-alpha levels and in hepatic MPO and collagen levels, and reduced the hepatic damage scores.
Positive_regulation (elevations) of Gene_expression (levels) of MPO associated with urological neuroanatomy
11) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18403049 Disease Relevance 1.21 Pain Relevance 0.24
Both (-)-naloxone and beta-FNA attenuated cerebral ischemia/reperfusion (I/R)-induced increases in neutrophil-associated myeloperoxidase activity and chemokine mRNA expression, including macrophage inflammatory protein-1 alpha and -2.
Positive_regulation (increases) of Gene_expression (expression) of myeloperoxidase in macrophage associated with chemokine, inflammation, cv general 4 under development, ischemia and narcan
12) Confidence 0.37 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12842283 Disease Relevance 0.53 Pain Relevance 0.72
This study measured plasma MPO and IL-17 levels in 10 patients with ACS, 11 age- and sex-matched patients with stable angina and 12 healthy control subjects.
Positive_regulation (measured) of Gene_expression (levels) of plasma MPO in plasma associated with acute coronary syndrome, angina and urological neuroanatomy
13) Confidence 0.36 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19589271 Disease Relevance 1.40 Pain Relevance 0.35
The first significant elevation in PGE 2 and LTB 4 levels and MPO activity were observed in stage III.
Positive_regulation (elevation) of Gene_expression (levels) of MPO
14) Confidence 0.32 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15897851 Disease Relevance 0.08 Pain Relevance 0
The drug significantly reduced the elevation in the paw edema, TNF-alpha, nitric oxide and myeloperoxidase levels when compared with adjuvant induced arthritic animals, which shows the anti-inflammatory activity of the drug.
Positive_regulation (elevation) of Gene_expression (levels) of myeloperoxidase in paw associated with pressure and volume under development, inflammation and arthritis
15) Confidence 0.31 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16595901 Disease Relevance 1.26 Pain Relevance 0.51
Omeprazole has significantly elevated the expression level of COX-2 protein, PGE2 level (19.37%), and decreased myeloperoxidase activity (81.92%), thereby causing the most effective ulcer healing (89.74%).
Positive_regulation (elevated) of Gene_expression (expression) of myeloperoxidase in PGE2 associated with ulcers
16) Confidence 0.31 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16139265 Disease Relevance 0.91 Pain Relevance 0.18
Infected control rats showed hypermotility, mast cell hyperplasia, increased RMCPII levels, increased myeloperoxidase, and overexpression of COX-2 and iNOS.
Positive_regulation (overexpression) of Gene_expression (overexpression) of myeloperoxidase in mast cell associated with hyperplasia
17) Confidence 0.31 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16988056 Disease Relevance 0.91 Pain Relevance 0.28
Conversely, chronically stressed (21 days) EAE-induced DA rats show increased 15d-PGJ2 levels, amelioration of clinical score, and reduced myelin loss, MMP-9 expression, MPO activity, and accumulation of neuroinflammatory mediators in the spinal cords of these animals.
Positive_regulation (increased) of Gene_expression (expression) of MPO in spinal cords associated with multiple sclerosis and urological neuroanatomy
18) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.58 Pain Relevance 0.16
Pretreatment with capsazepine, CGRP(8-37), indomethacin, and denervation of primary sensory nerves significantly increased blood urea nitrogen and serum creatinine levels, renal vascular permeability, renal tissue levels of myeloperoxidase activity, cytokine-induced neutrophil chemoattractant, and tumor necrosis factor-alpha, and decreased renal tissue blood flow.
Positive_regulation (increased) of Gene_expression (levels) of myeloperoxidase in blood
19) Confidence 0.28 Published 2009 Journal Anesthesiology Section Body Doc Link 19194162 Disease Relevance 0.13 Pain Relevance 0
Increases of spinal cord tissue levels of tumor necrosis factor, caspase-3, myeloperoxidase, and the number of apoptotic nerve cells were inhibited by the administration of limaprost.
Positive_regulation (Increases) of Gene_expression (levels) of myeloperoxidase in spinal cord associated with necrosis, cancer, apoptosis and spinal cord
20) Confidence 0.25 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.26 Pain Relevance 0.58

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