INT111514

Context Info Confidence 0.49 First Reported 2003 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 20 Total Number 20 Disease Relevance 15.13 Pain Relevance 3.88

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)

Anatomy Link Frequency plasma 8 liver 8 spinal cords 4 macrophage 2 PGE2 2 Mpo (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 36 100.00 chemokine 3 100.00 ischemia 19 99.46 Inflammation 60 99.08 narcan 8 98.62 Calcitonin gene-related peptide 6 97.64 Angina 7 97.16 antagonist 2 94.96 Opioid 1 94.52 anesthesia 8 93.08

Disease Link Frequency Relevance Heat Urological Neuroanatomy 109 100.00 Necrosis 6 100.00 Pressure And Volume Under Development 4 100.00 Cancer 4 100.00 Frailty 9 99.92 Multiple Sclerosis 132 99.56 Cardiovascular Disease 6 99.52 Cv General 4 Under Development 2 99.46 Hyperplasia 5 99.26 Apoptosis 3 99.20

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Anatomy

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Speculation

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Disease term

I/R significantly increased NADPH oxidase activity, H(2)O(2) production, and myeloperoxidase (MPO) activity.

Positive_regulation (increased) of Gene_expression (production) of MPO associated with urological neuroanatomy

1) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19942802 Disease Relevance 0.46 Pain Relevance 0.27

I/R significantly increased NADPH oxidase activity, H(2)O(2) production, and myeloperoxidase (MPO) activity.

Positive_regulation (increased) of Gene_expression (production) of myeloperoxidase associated with urological neuroanatomy

2) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19942802 Disease Relevance 0.46 Pain Relevance 0.27

Heparin, which is known to increase MPO plasma levels in patients with stable CAD, had no effect on MPO plasma levels in AMI patients.

Positive_regulation (increase) of Gene_expression (levels) of MPO in plasma associated with coronary artery disease, urological neuroanatomy and myocardial infarction

3) Confidence 0.46 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 1.91 Pain Relevance 0.09

Increased expression and plasma levels of myeloperoxidase are closely related to the presence of angiographically-detected complex lesion morphology in unstable angina.

Positive_regulation (Increased) of Gene_expression (expression) of myeloperoxidase in plasma associated with angina

4) Confidence 0.46 Published 2010 Journal Heart Section Title Doc Link 20956487 Disease Relevance 0.10 Pain Relevance 0.10

Moreover, MPO level is significantly higher in patients with unstable coronary artery disease and myocardial infarction compared with healthy subjects and patients with stable angina.

Positive_regulation (higher) of Gene_expression (level) of MPO in coronary artery associated with angina, cardiovascular disease, urological neuroanatomy and myocardial infarction

5) Confidence 0.46 Published 2010 Journal Int J Lab Hematol Section Abstract Doc Link 20201999 Disease Relevance 1.14 Pain Relevance 0.13

Hepatic MPO was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [18].

Positive_regulation (increase) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy

6) Confidence 0.46 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.37 Pain Relevance 0

Hepatic MPO was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [18].

Positive_regulation (recovery) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy

7) Confidence 0.46 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.37 Pain Relevance 0

MPO present in liver tissues was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [16].

Positive_regulation (increase) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy

8) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.44 Pain Relevance 0

MPO present in liver tissues was assayed as follows: the dialyzed supernatant was incubated at 60°C for 2 h to increase the recovery of MPO in liver tissues according to the method of Schierwagen et al. [16].

Positive_regulation (recovery) of Gene_expression (recovery) of MPO in liver associated with urological neuroanatomy

9) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.44 Pain Relevance 0

CONCLUSIONS: In stable angina patients, coronary stenting is associated with an acute and transient increase in plasma MPO levels, but not in lactoferrin levels, with an enhanced response in the presence of complex lesions.

Neg (not) Positive_regulation (increase) of Gene_expression (levels) of MPO in plasma

10) Confidence 0.44 Published 2009 Journal Eur. J. Intern. Med. Section Body Doc Link 19712859 Disease Relevance 0.18 Pain Relevance 0

Oxytocin treatment significantly reversed the I/R-induced elevations in serum transaminase and TNF-alpha levels and in hepatic MPO and collagen levels, and reduced the hepatic damage scores.

Positive_regulation (elevations) of Gene_expression (levels) of MPO associated with urological neuroanatomy

11) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18403049 Disease Relevance 1.21 Pain Relevance 0.24

Both (-)-naloxone and beta-FNA attenuated cerebral ischemia/reperfusion (I/R)-induced increases in neutrophil-associated myeloperoxidase activity and chemokine mRNA expression, including macrophage inflammatory protein-1 alpha and -2.

Positive_regulation (increases) of Gene_expression (expression) of myeloperoxidase in macrophage associated with chemokine, inflammation, cv general 4 under development, ischemia and narcan

12) Confidence 0.37 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12842283 Disease Relevance 0.53 Pain Relevance 0.72

This study measured plasma MPO and IL-17 levels in 10 patients with ACS, 11 age- and sex-matched patients with stable angina and 12 healthy control subjects.

Positive_regulation (measured) of Gene_expression (levels) of plasma MPO in plasma associated with acute coronary syndrome, angina and urological neuroanatomy

13) Confidence 0.36 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19589271 Disease Relevance 1.40 Pain Relevance 0.35

The first significant elevation in PGE 2 and LTB 4 levels and MPO activity were observed in stage III.

Positive_regulation (elevation) of Gene_expression (levels) of MPO

14) Confidence 0.32 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15897851 Disease Relevance 0.08 Pain Relevance 0

The drug significantly reduced the elevation in the paw edema, TNF-alpha, nitric oxide and myeloperoxidase levels when compared with adjuvant induced arthritic animals, which shows the anti-inflammatory activity of the drug.

Positive_regulation (elevation) of Gene_expression (levels) of myeloperoxidase in paw associated with pressure and volume under development, inflammation and arthritis

15) Confidence 0.31 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16595901 Disease Relevance 1.26 Pain Relevance 0.51

Omeprazole has significantly elevated the expression level of COX-2 protein, PGE2 level (19.37%), and decreased myeloperoxidase activity (81.92%), thereby causing the most effective ulcer healing (89.74%).

Positive_regulation (elevated) of Gene_expression (expression) of myeloperoxidase in PGE2 associated with ulcers

16) Confidence 0.31 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16139265 Disease Relevance 0.91 Pain Relevance 0.18

Infected control rats showed hypermotility, mast cell hyperplasia, increased RMCPII levels, increased myeloperoxidase, and overexpression of COX-2 and iNOS.

Positive_regulation (overexpression) of Gene_expression (overexpression) of myeloperoxidase in mast cell associated with hyperplasia

17) Confidence 0.31 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16988056 Disease Relevance 0.91 Pain Relevance 0.28

Conversely, chronically stressed (21 days) EAE-induced DA rats show increased 15d-PGJ2 levels, amelioration of clinical score, and reduced myelin loss, MMP-9 expression, MPO activity, and accumulation of neuroinflammatory mediators in the spinal cords of these animals.

Positive_regulation (increased) of Gene_expression (expression) of MPO in spinal cords associated with multiple sclerosis and urological neuroanatomy

18) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.58 Pain Relevance 0.16

Pretreatment with capsazepine, CGRP(8-37), indomethacin, and denervation of primary sensory nerves significantly increased blood urea nitrogen and serum creatinine levels, renal vascular permeability, renal tissue levels of myeloperoxidase activity, cytokine-induced neutrophil chemoattractant, and tumor necrosis factor-alpha, and decreased renal tissue blood flow.

Positive_regulation (increased) of Gene_expression (levels) of myeloperoxidase in blood

19) Confidence 0.28 Published 2009 Journal Anesthesiology Section Body Doc Link 19194162 Disease Relevance 0.13 Pain Relevance 0

Increases of spinal cord tissue levels of tumor necrosis factor, caspase-3, myeloperoxidase, and the number of apoptotic nerve cells were inhibited by the administration of limaprost.

Positive_regulation (Increases) of Gene_expression (levels) of myeloperoxidase in spinal cord associated with necrosis, cancer, apoptosis and spinal cord

20) Confidence 0.25 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.26 Pain Relevance 0.58

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