INT111520

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.25
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
neuronal 1
blood 1
neurons 1
sympathetic 1
tail skin 1
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 31 100.00 Very High Very High Very High
qutenza 263 99.84 Very High Very High Very High
dorsal root ganglion 222 99.64 Very High Very High Very High
cytokine 28 99.10 Very High Very High Very High
nociceptor 10 98.12 Very High Very High Very High
Eae 8 97.76 Very High Very High Very High
antagonist 25 97.08 Very High Very High Very High
guanethidine 1 95.04 Very High Very High Very High
Cancer pain 1 93.16 High High
Paracetamol 7 92.64 High High
Disease Link Frequency Relevance Heat
Lymphedema 45 99.96 Very High Very High Very High
Wallerian Degeneration 2 99.68 Very High Very High Very High
Ganglion Cysts 226 99.64 Very High Very High Very High
Injury 12 97.76 Very High Very High Very High
Targeted Disruption 44 96.72 Very High Very High Very High
Hepatotoxicity 2 94.88 High High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 65 94.16 High High
Cancer Pain 1 93.16 High High
Pain 33 91.60 High High
Hyperalgesia 47 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that endoneurial TNFR1 and TNFR2 proteins are differentially regulated during Wallerian degeneration.
Regulation (regulated) of TNFR1 associated with wallerian degeneration
1) Confidence 0.61 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.12 Pain Relevance 0.44
It is not clear at this time which component is acting as the factor regulating the TNFR1 in our experiment.
Regulation (regulating) of TNFR1
2) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.45 Pain Relevance 0.41
Delayed induction of heme oxygenase-1 and reduced expression of CuZn superoxide dismutase were also observed in TNFR1-/- compared with WT mice.
Regulation (observed) of TNFR1
3) Confidence 0.45 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12842828 Disease Relevance 0.55 Pain Relevance 0.49
– a concept difficult to rationalise as mutations would be predicted to have a profound effect on the overall structure of TNFRI, and which is not supported by binding measurements of radiolabelled TNF?
Regulation (effect) of TNFRI
4) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.50 Pain Relevance 0.03
It is of considerable interest that ROS are signaling molecules in the regulation of TNFR1 increase after TRPV1 activation.
Regulation (regulation) of TNFR1
5) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.54 Pain Relevance 0.48
IL-18 hypernociception was unaffected in TNFR1(-/-) mice or by the pre-treatment with sIL-15Ralpha (soluble form of IL-15 receptor), BQ788 (ET(B) receptor antagonist) or guanethidine (sympathetic blocker).
Neg (unaffected) Regulation (unaffected) of TNFR1 in sympathetic associated with guanethidine and antagonist
6) Confidence 0.36 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.24 Pain Relevance 0.35
The present study investigated changes in TNFR1 in response to TRPV1 activation in primary DRG neuronal cultures from both TRPV1 knockout and wild type mice while monitoring involvement of ROS as a potential drive in this signaling pathway.
Spec (investigated) Regulation (changes) of TNFR1 in neuronal associated with targeted disruption and dorsal root ganglion
7) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.32 Pain Relevance 0.83
Regulation of TNFR1 by capsaicin
Regulation (Regulation) of TNFR1 associated with qutenza
8) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.72 Pain Relevance 0.78
Coexpression of mRNA for TNFR1 and TRPV1 receptors [17] and colocalization of TNFR1 and TRPV1 immunoreactivity [29] in DRG neurons has been reported.
Regulation (immunoreactivity) of TNFR1 in neurons associated with dorsal root ganglion
9) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.71 Pain Relevance 1.28
Cytokine levels in tail skin were measured in normal controls and mice with untreated, NSAID-treated, and sTNF-R1-treated lymphedema (n?
Regulation (controls) of sTNF-R1-treated in tail skin associated with cinod, lymphedema and cytokine
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.10 Pain Relevance 0.32
Changes of the level of IL-6, IL-1beta, TNF and sTNFRI in the blood of children with idiopathic headache do not indicate a significant role of inflammatory process in its pathogenesis. 2.
Regulation (Changes) of sTNFRI in blood
11) Confidence 0.00 Published 2005 Journal Prz. Lek. Section Body Doc Link 16512619 Disease Relevance 0 Pain Relevance 0

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