INT111528

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.24
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
osteoclasts 2
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 1 99.58 Very High Very High Very High
Inflammatory mediators 2 99.08 Very High Very High Very High
Morphine 16 98.36 Very High Very High Very High
nMDA receptor 8 97.32 Very High Very High Very High
Pain 21 90.52 High High
Inflammation 45 88.80 High High
Arthritis 37 87.60 High High
opioid receptor 3 86.64 High High
Dorsal horn 21 84.24 Quite High
Spontaneous pain 1 82.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 40 98.88 Very High Very High Very High
Hypercalcemia 7 96.72 Very High Very High Very High
Pressure And Volume Under Development 11 94.40 High High
Pain 23 90.52 High High
Arthritis 53 87.60 High High
Injury 7 87.36 High High
Hyperplasia 10 86.24 High High
Targeted Disruption 87 85.36 High High
Inflammatory Pain 9 79.92 Quite High
Cancer 4 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only when NFATc1 was co-overexpressed with c-fos was the inhibitory effect of morphine on IFN-gamma promoter counteracted.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NFATc1 associated with morphine
1) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.32 Pain Relevance 1.26
Remarkably, overexpression of activated NFATc1 in these ?
Positive_regulation (activated) of Gene_expression (overexpression) of NFATc1
2) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.44 Pain Relevance 0
Remarkably, overexpression of activated NFATc1 in these ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of NFATc1
3) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.44 Pain Relevance 0
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Positive_regulation (increases) of Gene_expression (expression) of NFATc1 in osteoclasts associated with hypercalcemia
4) Confidence 0.34 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.00 Pain Relevance 0.28
Many inflammatory mediators - for example bradykinin - are also known to induce NFAT expression, so it is likely that enhanced expression of ephrin-B2 results in NMDA receptor NR2B phosphorylation that potentiates synaptic efficacy and increase calcium flux.
Positive_regulation (induce) of Gene_expression (expression) of NFAT associated with inflammatory mediators, nmda receptor and bradykinin
5) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.04 Pain Relevance 0.98

General Comments

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