INT111529

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 41
Total Number 43
Disease Relevance 21.14
Pain Relevance 13.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) protein complex assembly (Mapk3) protein complex (Mapk3)
cytoplasm (Mapk3) cytosol (Mapk3) signal transduction (Mapk3)
Anatomy Link Frequency
peritoneal macrophages 6
dorsal horn 2
hepatocytes 1
striatum 1
nucleus 1
Mapk3 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 13 99.80 Very High Very High Very High
Morphine 27 99.78 Very High Very High Very High
nMDA receptor 21 99.68 Very High Very High Very High
spinal dorsal horn 3 99.56 Very High Very High Very High
Kinase C 287 99.40 Very High Very High Very High
cytokine 31 99.40 Very High Very High Very High
qutenza 9 99.40 Very High Very High Very High
Rostral ventrolateral medulla 55 98.96 Very High Very High Very High
Dorsal horn 27 98.88 Very High Very High Very High
Pain 38 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 32 99.78 Very High Very High Very High
Apoptosis 158 99.52 Very High Very High Very High
Pain 28 98.84 Very High Very High Very High
Injury 400 98.60 Very High Very High Very High
Cancer 584 98.36 Very High Very High Very High
Bordatella Infection 22 97.96 Very High Very High Very High
Nervous System Injury 2 97.08 Very High Very High Very High
Sleep Disorders 5 96.44 Very High Very High Very High
Metastasis 80 96.00 Very High Very High Very High
Hypersensitivity 7 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibited phosphorylation of ERK1/2 and p38 MAPK; in addition, morphine treatment in the presence of either ERK1/2 or p38 MAPK inhibitor (PD98059 or SB203580) resulted in an additive inhibition of IFN-gamma promoter activity.
Phosphorylation (phosphorylation) of ERK1 associated with morphine
1) Confidence 0.80 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.32 Pain Relevance 1.06
Here we show that acute (1 d) or chronic (4 weeks) exposure to unpredictable stress increases phosphorylation of ERK1/2 and of two downstream targets (ribosomal S6 kinase and mitogen- and stress-activated protein kinase 1) within the ventral tegmental area (VTA), an important substrate for motivated behavior and mood regulation.
Phosphorylation (phosphorylation) of ERK1 in ventral associated with stress and ventral tegmentum
2) Confidence 0.80 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.62 Pain Relevance 0.20
Morphine exposure and withdrawal increase phosphorylation of NR1 and NR2B receptors, ERK1/2, calmodulin-dependent kinase II, and cAMP response element binding proteins; and such phosphorylation is suppressed by either spinal inhibition or targeted mutation of MMP-9.
Phosphorylation (phosphorylation) of ERK1 in spinal associated with withdrawal and morphine
3) Confidence 0.80 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.31 Pain Relevance 1.32
Capsazepine also suppressed RANKL induced IkappaB and ERK1/2 phosphorylation and caused apoptosis of mature osteoclasts and also inhibited alkaline phosphatase activity and bone nodule formation in calvarial osteoblast cultures.
Phosphorylation (phosphorylation) of ERK1 in osteoblast associated with osteoporosis and apoptosis
4) Confidence 0.80 Published 2010 Journal Bone Section Abstract Doc Link 20096813 Disease Relevance 1.07 Pain Relevance 0.33
Furthermore, MEAD inhibited the activating phosphorylation of ERK1/2.
Phosphorylation (phosphorylation) of ERK1
5) Confidence 0.80 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 19051357 Disease Relevance 0.75 Pain Relevance 0.22
Fluoxetine treatment could reverse CMS-induced inhibition of PKA activity and ERK1/2 phosphorylation in both genotypes.
Phosphorylation (phosphorylation) of ERK1 associated with stress and fluoxetine
6) Confidence 0.80 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.32 Pain Relevance 0.73
Moreover, we demonstrate that phosphorylation of extracellular-signal regulated kinase 1/2 (ERK1/2) is downstream of mGluR5 activation in the CeA and is necessary for the full expression of peripheral inflammation-induced behavioral sensitization.
Phosphorylation (phosphorylation) of ERK1 in CeA associated with inflammation and amygdala
7) Confidence 0.80 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 1.01 Pain Relevance 0.77
Cytokines administration did not alter ERK1/2 and JNK1/2 phosphorylation.
Phosphorylation (phosphorylation) of ERK1 associated with cytokine
8) Confidence 0.80 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17678631 Disease Relevance 0.24 Pain Relevance 0.68
CYP2E1 is induced by alcohol and the primary P450 that carries out ethanol oxidation that can lead to the production of activated oxygen species and oxidative stress that elevate ERK1/2 phosphorylation through EGRF/c-Raf signaling.
Phosphorylation (phosphorylation) of ERK1 associated with stress and alcohol
9) Confidence 0.80 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15603755 Disease Relevance 1.13 Pain Relevance 0.29
Enzastaurin treatment of 4T1 cells blocked the phosphorylation of PKCbeta, as well as Ras and two of its downstream effectors ERK1/2 and RAL-GTP.
Phosphorylation (phosphorylation) of ERK1 in 4T1
10) Confidence 0.79 Published 2008 Journal Invest New Drugs Section Abstract Doc Link 17805485 Disease Relevance 1.15 Pain Relevance 0.28
Both mustard oil and capsaicin produced a redistribution of phosphorylated ERK1/2 from cytosol into the nucleus that was statistically significant at 45 min after treatment.
Phosphorylation (phosphorylated) of ERK1 in nucleus associated with qutenza
11) Confidence 0.79 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941468 Disease Relevance 0.49 Pain Relevance 1.12
Cd increased phosphorylation of p38 MAPK, but not of JNK and ERK1/2.
Phosphorylation (phosphorylation) of ERK1
12) Confidence 0.79 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.33 Pain Relevance 0.09
In contrast, it was still present in mice deleted for each of the alpha2AR subtypes and was markedly decreased by the antagonist of the I1-imidazoline receptors efaroxan, by phospholipase C and protein kinase C inhibitors, and by PD 098059, a direct inhibitor of ERK1 and 2 phosphorylation.
Phosphorylation (phosphorylation) of ERK1
13) Confidence 0.72 Published 2008 Journal Anesthesiology Section Body Doc Link 18292683 Disease Relevance 0 Pain Relevance 0
Recent studies have emphasized the role of phosphorylated extracellular signal-regulated protein kinases (pERK1 and 2) in coupling rapid events such as neurotransmitter release and receptor stimulation long-lasting changes in synaptic plasticity and cell survival.
Phosphorylation (phosphorylated) of pERK1 associated with neurotransmitter
14) Confidence 0.63 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18292683 Disease Relevance 0.10 Pain Relevance 0.19
Despite activation (phosphorylation) of ERK1 after acute noxious stimulation and in models of chronic pain, we found that ERK1 was not required for formalin-induced spontaneous behaviors, complete Freund's adjuvant-induced heat and mechanical hypersensitivity, and spared nerve injury-induced mechanical hypersensitivity.
Phosphorylation (phosphorylation) of ERK1 in nerve associated with nervous system injury, lasting pain and hypersensitivity
15) Confidence 0.62 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739576 Disease Relevance 1.16 Pain Relevance 0.36
Several immunocytochemical studies have demonstrated activity-dependent phosphorylation of extracellular signal-related kinases 1 and 2 (ERK1/2) in the spinal dorsal horn after various types of noxious stimulus or nerve injury in vivo, and after electrical stimulation of A?
Phosphorylation (phosphorylation) of ERK1 in dorsal horn associated with nervous system injury and spinal dorsal horn
16) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC1803781 Disease Relevance 0.10 Pain Relevance 0.26
Application of glutamate to hippocampal cell cultures induces an NMDA-R -dependent increase in ERK1/2 phosphorylation [34], [43].
Phosphorylation (phosphorylation) of ERK1 associated with glutamate
17) Confidence 0.61 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.16
Interestingly, phosphorylated ERK1/2 (pERK1/2) at Thr202 and Tyr204 in RVLM was significantly and preferentially augmented during the pro-life phase (fig. 2), of which returned to baseline during the pro-death phase.
Phosphorylation (phosphorylated) of ERK1 associated with rostral ventrolateral medulla and death
18) Confidence 0.61 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.69 Pain Relevance 0.34
The CMS procedure inhibited hippocampal protein kinase A (PKA) activity, extracellular signal-regulated kinases (ERK1/2), and calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylation in AQP4(+/+) and AQP4(-/-) mice.
Phosphorylation (phosphorylation) of ERK1 associated with stress
19) Confidence 0.61 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.38 Pain Relevance 0.66
Moreover, both DOI-induced cell proliferation and phosphorylation of ERK1 and 2 proteins were inhibited by PD98059 and U0126, selective inhibitors of MEK in a concentration-dependent manner.
Phosphorylation (phosphorylation) of ERK1
20) Confidence 0.58 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399747 Disease Relevance 0.28 Pain Relevance 0.22

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