INT111530

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 4
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 30 99.98 Very High Very High Very High
opioid receptor 6 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.36 Very High Very High Very High
Bordatella Infection 2 66.12 Quite High
Infection 2 42.04 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 41.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effects of morphine were not observed in T cells obtained from mu-opioid receptor knockout mice, suggesting that morphine modulation of IFN-gamma promoter activity is mediated through the mu-opioid receptor.
Positive_regulation (mediated) of Regulation (modulation) of IFN-gamma in T cells associated with targeted disruption, opioid receptor and morphine
1) Confidence 0.41 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.17 Pain Relevance 1.06
In summary, our data indicate that morphine modulation of IFN-gamma promoter activity is mediated through two distinct cAMP-dependent pathways, the NF-kappaB signaling pathway and the ERK1/2, p38 MAPK, AP-1/NFAT pathway.
Positive_regulation (mediated) of Regulation (modulation) of IFN-gamma in NFAT associated with morphine
2) Confidence 0.41 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.15 Pain Relevance 0.96

General Comments

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