INT111531

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 20.00
Pain Relevance 17.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
neurons 10
podocytes 2
midbrain 2
microglia 2
spinal 2
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 675 99.98 Very High Very High Very High
intrathecal 153 99.98 Very High Very High Very High
Morphine 22 99.98 Very High Very High Very High
Brush evoked pain 5 99.88 Very High Very High Very High
allodynia 585 99.44 Very High Very High Very High
Spinal cord 92 99.00 Very High Very High Very High
midbrain 2 98.16 Very High Very High Very High
cytokine 133 97.92 Very High Very High Very High
Kinase C 23 96.48 Very High Very High Very High
Sciatic nerve 5 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 676 99.98 Very High Very High Very High
Neuropathic Pain 730 99.88 Very High Very High Very High
Cardiomyopathy 63 99.72 Very High Very High Very High
Nervous System Injury 56 99.36 Very High Very High Very High
Aging 499 99.26 Very High Very High Very High
Cancer 487 98.84 Very High Very High Very High
Bullous Skin Disease 304 98.84 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 1 97.60 Very High Very High Very High
Bordatella Infection 1 95.88 Very High Very High Very High
Glioma 3 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, we demonstrate that intrathecal administration of SB203580 completely blocks p38 phosphorylation and mechanical allodynia.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of p38 associated with allodynia and intrathecal
1) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.40 Pain Relevance 0.97
Intrathecal administration of SB203580 blocks p38 phosphorylation in both DRG neurons and spinal cord cells (including neurons, astrocytes and microglia), according to previous studies [13,14,32,33].
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of p38 in neurons associated with spinal cord and intrathecal
2) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.44 Pain Relevance 0.99
Anti-NGF treatment completely blocked p38 phosphorylation in LDRG in db/db mice and subsequent mechanical allodynia.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of p38 associated with allodynia and nerve growth factor
3) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.32 Pain Relevance 1.30
Mechanical thresholds were measured at the end of the SB203580 treatment. pp38 immunoblots confirmed the inhibition of p38 phosphorylation in LDRG in response to SB203580 treatment in both db+ and db/db mice (Fig. 4A).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of p38
4) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.34 Pain Relevance 0.60
Intrathecal injection of IL-1beta and TNF-alpha significantly increased p38(MAPK) phosphorylation and this was inhibited by myricitrin treatment.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38 associated with intrathecal
5) Confidence 0.40 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17678631 Disease Relevance 0.25 Pain Relevance 0.66
Upon SOD2 overexpression, the deficits in axonal transport recovered in association with restoration of levels of phosphorylated p38 MAPK and tau protein.
Negative_regulation (recovered) of Phosphorylation (phosphorylated) of p38 MAPK
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.00 Pain Relevance 0.10
At 12 wk of age, p38 phosphorylation in db/db mice was reduced to the control level (Fig. 1A).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p38
7) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.95 Pain Relevance 0.80
Intrathecal administration of SB203580 blocks p38 phosphorylation in both DRG neurons and spinal cord cells (including neurons, astrocytes and microglia), according to previous studies [13,14,32,33].
Negative_regulation (administration) of Phosphorylation (phosphorylation) of p38 in neurons associated with spinal cord and intrathecal
8) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.44 Pain Relevance 1.00
Anti-NGF inhibits the phosphorylation of p38 in db/db mice
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of p38 associated with nerve growth factor
9) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.36 Pain Relevance 0.69
Densitometric analysis demonstrated a reversal of p38 phosphorylation in db/db mice down to the levels observed in the control db+ mice (Fig. 4B).
Negative_regulation (reversal) of Phosphorylation (phosphorylation) of p38
10) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.35 Pain Relevance 0.56
Treatments with anti-NGF at 6 and 7 wk of age significantly decreased the phosphorylation of p38 in LDRG of db/db mice at 8 wk of age (Fig. 3A).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38 associated with nerve growth factor
11) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.39 Pain Relevance 0.89
Densitometric studies further determined that anti-NGF reversed the p38 phosphorylation in db/db mice but did not affect the baseline p38 phosphorylation in LDRG of db+ nondiabetic mice (Fig. 3B).


Negative_regulation (reversed) of Phosphorylation (phosphorylation) of p38 associated with nerve growth factor
12) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.40 Pain Relevance 0.87
In conjunction with the inhibition of p38 phosphorylation, SB203580 treatment inhibited mechanical allodynia in db/db mice (Fig. 4C) and lowered the percentage of substance P (SP)-positive neurons (Fig. 4D).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of p38 in neurons associated with allodynia and substance p
13) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.43 Pain Relevance 0.62
We found here for the first time that nerve injury produces a sustained and significant reduction in protein levels of phosphorylated-ERK and -p38 in cytosolic preparations of the mouse lower midbrain.
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of p38 in midbrain associated with nervous system injury and midbrain
14) Confidence 0.36 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.34 Pain Relevance 1.22
did work in our hands; however, we expect similar degrees of ablation of p38?
Negative_regulation (degrees) of Phosphorylation (ablation) of p38
15) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.15 Pain Relevance 0
Cur stimulates phosphorylation of p38MAPK and HSP25 in cultured podocytes
Negative_regulation (podocytes) of Phosphorylation (phosphorylation) of p38MAPK in podocytes
16) Confidence 0.34 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.06 Pain Relevance 0.06
Morphine inhibited phosphorylation of ERK1/2 and p38 MAPK; in addition, morphine treatment in the presence of either ERK1/2 or p38 MAPK inhibitor (PD98059 or SB203580) resulted in an additive inhibition of IFN-gamma promoter activity.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38 MAPK associated with morphine
17) Confidence 0.26 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.32 Pain Relevance 1.06
Intrathecal administration of TLR3 antisense oligodeoxynucleotide suppressed nerve injury-induced tactile allodynia, and decreased the phosphorylation of p38 mitogen-activated protein kinase, but not extracellular signal-regulated protein kinases 1/2, in spinal glial cells.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38 in spinal associated with brush evoked pain, nervous system injury and intrathecal
18) Confidence 0.21 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18363823 Disease Relevance 0.96 Pain Relevance 0.63
B phosphorylation
               as well as inhibited p38 phosphorylation without overt interactions between the two.
               
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.77 Pain Relevance 0
Our data revealed reduced p38 MAP kinase phosphorylation in aged and
               obese mice, while leptin effectively restored p38 phosphorylation in young
                   ob/ob but not aging mice. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p38 MAP kinase associated with aging and obesity
20) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.66 Pain Relevance 0

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