INT111532

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.27
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
osteoclasts 2
macrophages 1
smooth muscle 1
epithelial cells 1
eosinophils 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 1 99.44 Very High Very High Very High
Inflammatory mediators 19 98.94 Very High Very High Very High
Morphine 16 98.36 Very High Very High Very High
nMDA receptor 8 97.32 Very High Very High Very High
Nerve growth factor 6 95.16 Very High Very High Very High
cytokine 707 93.40 High High
Pain 24 90.24 High High
Inflammation 800 88.24 High High
dorsal root ganglion 3 88.00 High High
Arthritis 82 87.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 852 98.74 Very High Very High Very High
Hypercalcemia 13 96.72 Very High Very High Very High
Nociception 10 94.40 High High
Pressure And Volume Under Development 19 93.84 High High
Osteoporosis 9 92.40 High High
Pain 27 90.24 High High
Ganglion Cysts 3 88.00 High High
Injury 7 87.08 High High
Arthritis 102 87.04 High High
Hyperplasia 72 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only when NFATc1 was co-overexpressed with c-fos was the inhibitory effect of morphine on IFN-gamma promoter counteracted.
Gene_expression (overexpressed) of NFATc1 associated with morphine
1) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.32 Pain Relevance 1.26
B pathways, thereby suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors [36].


Gene_expression (expression) of NFATc1 in osteoclast
2) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.64 Pain Relevance 0.12
Remarkably, overexpression of activated NFATc1 in these ?
Gene_expression (overexpression) of NFATc1
3) Confidence 0.62 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.44 Pain Relevance 0
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Gene_expression (expression) of NFATc1 in osteoclasts associated with hypercalcemia
4) Confidence 0.53 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.99 Pain Relevance 0.28
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in epithelial cells
5) Confidence 0.24 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
Many inflammatory mediators - for example bradykinin - are also known to induce NFAT expression, so it is likely that enhanced expression of ephrin-B2 results in NMDA receptor NR2B phosphorylation that potentiates synaptic efficacy and increase calcium flux.
Gene_expression (expression) of NFAT associated with inflammatory mediators, nmda receptor and bradykinin
6) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.04 Pain Relevance 0.98
Both NFAT and NF-?
Gene_expression (Both) of NFAT
7) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.22 Pain Relevance 0.11
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in macrophages
8) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in monocytes
9) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in eosinophils
10) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in mast cells
11) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in smooth muscle
12) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
However, we now know that NFAT is not T cell specific but is also expressed in many other types of cells (e.g. mast cells, monocytes, macrophages, eosinophils, epithelial cells, smooth muscle and endothelial cells) [135,136].
Gene_expression (expressed) of NFAT in endothelial cells
13) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.13 Pain Relevance 0.04
[70-72]. p38 MAPK can positively and negatively modulate NFAT activity by several mechanisms. p38 MAPK can induce NFAT expression at the transcriptional and post-transcriptional levels and can promote the interaction of NFAT with the coactivator CREB-binding protein (CBP).
Gene_expression (expression) of NFAT in NFAT
14) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.19
Within cultured spinal cells, BDNF also activated CaN-dependent, NFAT-regulated gene expression.
Gene_expression (expression) of NFAT-regulated in spinal
15) Confidence 0.00 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17488277 Disease Relevance 0.61 Pain Relevance 0.52

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