INT111533

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 17.32
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
macrophage 6
monocytes 6
pancreatic islet 4
exocrine pancreas 2
colons 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 63 100.00 Very High Very High Very High
chemokine 58 100.00 Very High Very High Very High
Morphine 22 99.92 Very High Very High Very High
Inflammation 283 99.68 Very High Very High Very High
Nicotine 40 98.82 Very High Very High Very High
COX2 2 98.78 Very High Very High Very High
headache 2 97.08 Very High Very High Very High
cocaine 8 96.44 Very High Very High Very High
rheumatoid arthritis 32 95.60 Very High Very High Very High
neuralgia 1 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 356 100.00 Very High Very High Very High
Cancer 125 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Pancreatic Cancer 7 99.56 Very High Very High Very High
Stress 84 99.34 Very High Very High Very High
Diabetes Mellitus 38 99.12 Very High Very High Very High
Death 100 99.00 Very High Very High Very High
Acute Coronary Syndrome 10 98.88 Very High Very High Very High
Targeted Disruption 30 98.08 Very High Very High Very High
Apoptosis 107 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of NF-kappaB p65 rescued the inhibitory effect of morphine on IFN-gamma promoter activity.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NF-kappaB p65 associated with morphine
1) Confidence 0.52 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.33 Pain Relevance 1.26
B-p65 and -p50 expression after exposure in Ppar?
Positive_regulation (-) of Gene_expression (expression) of p50
2) Confidence 0.46 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.08
In this work, we studied transgenic glial fibrillary acidic protein-IkappaBalpha-dn mice that selectively inactivate the classical nuclear factor kappaB pathway by overexpressing the inhibitory protein of kappaBalpha in astrocytes, under the control of glial fibrillary acidic protein promoter.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of nuclear factor kappaB in astrocytes associated with targeted disruption
3) Confidence 0.44 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.54 Pain Relevance 0.20
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Positive_regulation (accompanied) of Gene_expression (expression) of nuclear factor kappa B in colons associated with cancer
4) Confidence 0.41 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.19 Pain Relevance 0.24
Lignocaine and TTX significantly attenuated the effects of LPS on TLR-4, NF-kappaB, ERK and p38 MAPK expression, but not on JNK.
Neg (not) Positive_regulation (on) of Gene_expression (expression) of NF-kappaB
5) Confidence 0.38 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.11 Pain Relevance 0.36
Participation of NF-kappaB in the bladder responses to BCG
Positive_regulation (responses) of Gene_expression (Participation) of NF-kappaB in bladder
6) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.11 Pain Relevance 0
NF-kappaB was replaced largely by E2F1 in concert with gene activation during the early stage (12 h) of serum stimulation.
Positive_regulation (activation) of Gene_expression (replaced) of NF-kappaB
7) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.60 Pain Relevance 0.13
Lastly, oxidative stress is one of the principal factors inducing the expression of the nuclear factor Kappa B (NF-?
Positive_regulation (inducing) of Gene_expression (expression) of nuclear factor Kappa B associated with stress
8) Confidence 0.32 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2883961 Disease Relevance 0.64 Pain Relevance 0.12
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of nuclear factor-kappaB
9) Confidence 0.25 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
[24] were found to express high levels of the nuclear factor kappa B (NF?
Positive_regulation (levels) of Gene_expression (express) of nuclear factor kappa B
10) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794510 Disease Relevance 1.70 Pain Relevance 0.48
Furthermore, CD28 co-stimulation synergizes with TCR activation and induces IL-2, IL-4, IL-5, tumor necrosis factor (TNF), and granulocyte macrophage colony-stimulating factor production via nuclear factor-kappa B (NF-?
Positive_regulation (via) of Gene_expression (production) of nuclear factor-kappa B in macrophage associated with necrosis and cancer
11) Confidence 0.16 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.54 Pain Relevance 0
Our results suggest that elevated plasma level of ADMA induces TF expression in monocytes via NF-kappaB-dependent pathway, which contributes to procoagulant phenotype of circulating monocytes in ACS.
Positive_regulation (induces) of Gene_expression (expression) of NF-kappaB in monocytes associated with acute coronary syndrome
12) Confidence 0.15 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 19167713 Disease Relevance 0.78 Pain Relevance 0.39
Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes.
Positive_regulation (induces) of Gene_expression (expression) of NF-kappaB in monocytes associated with acute coronary syndrome
13) Confidence 0.15 Published 2009 Journal Atherosclerosis Section Title Doc Link 19167713 Disease Relevance 0.87 Pain Relevance 0.43
Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.
Positive_regulation (lipopolysaccharide-induced) of Gene_expression (production) of nuclear factor-kappaB in macrophages associated with necrosis, cancer and cox2
14) Confidence 0.13 Published 2007 Journal Pharmacol. Res. Section Title Doc Link 17229575 Disease Relevance 1.36 Pain Relevance 0.42
g of nuclear extract was performed using rabbit antibodies against Sp1 and the p50 and p65 subunits of NF-?
Positive_regulation (antibodies) of Gene_expression (using) of p50
15) Confidence 0.11 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.15 Pain Relevance 0.16
Iho et al. showed that nicotine induces human neutrophils to produce IL-8 (CXC chemokine) through the production of ROS and subsequent activation of NF-kB, with no effect on monocytes [43].
Positive_regulation (through) of Gene_expression (production) of NF-kB in monocytes associated with chemokine and nicotine
16) Confidence 0.10 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.51 Pain Relevance 0.46
In endothelial cells, G2A expression blocks NF-kB activation and chemokine expression, thus inhibiting macrophage accumulation [45], which suggests that G2A expression may have a protective role for prevention of early events of inflammation.
Positive_regulation (activation) of Gene_expression (expression) of NF-kB in macrophage associated with chemokine and inflammation
17) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.95 Pain Relevance 0.64
S100B also activates RAGE together with HMGB1, promoting the production of the transcription factor NF-kB [144].
Positive_regulation (promoting) of Gene_expression (production) of NF-kB
18) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.00 Pain Relevance 0.20
Overexpression of IkappaB inhibited NF-kappaB reporter activity at low (1 x 10(-4) M) but not high (1 x 10(-2) M) cocaine concentrations.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IkappaB associated with cocaine
19) Confidence 0.10 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14501032 Disease Relevance 0 Pain Relevance 0.90
Total expression and activation of the nuclear factor-kappa B (NF-?
Positive_regulation (activation) of Gene_expression (expression) of nuclear factor-kappa B
20) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.88 Pain Relevance 0

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