INT111547

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.08
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 2
internal 2
HT-1080 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 20 100.00 Very High Very High Very High
Opioid 22 99.12 Very High Very High Very High
rheumatoid arthritis 77 94.96 High High
Potency 4 94.00 High High
imagery 2 92.32 High High
Morphine 18 86.84 High High
Glutamate 1 80.40 Quite High
nMDA receptor 1 79.60 Quite High
opiate 22 75.00 Quite High
headache 2 70.88 Quite High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 29 99.84 Very High Very High Very High
Injury 5 98.68 Very High Very High Very High
Fibromyalgia 4 98.04 Very High Very High Very High
Fibrosarcoma 8 97.32 Very High Very High Very High
Apoptosis 4 96.72 Very High Very High Very High
Rheumatoid Arthritis 77 94.96 High High
Corneal Neovascularization 3 94.84 High High
Myelodysplastic Syndromes 11 93.28 High High
Hyperinsulinism 2 89.36 High High
Cancer 48 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vatalanib decreased VEGF levels and VEGFR phosphorylation in AML cells, which showed FLT3 internal tandem reduplications/mutations (ITD), raising the question of the actual targeted tyrosine kinase (VEGFR or flt3).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of VEGF in internal associated with myeloid leukemia
1) Confidence 0.42 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.72 Pain Relevance 0
MNTX inhibited MS, DAMGO and VEGF induced tyrosine phosphorylation (transactivation) of VEGF receptors 1 and 2.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of VEGF
2) Confidence 0.40 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0.06 Pain Relevance 0.68
Taken together, these results indicate that MNTX inhibits opioid-induced EC proliferation and migration via inhibition of VEGF receptor phosphorylation/transactivation with subsequent inhibition of RhoA activation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation/transactivation) of VEGF associated with opioid
3) Confidence 0.39 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0 Pain Relevance 0.56
Taken together, these results indicate that MNTX inhibits opioid-induced EC proliferation and migration via inhibition of VEGF receptor phosphorylation/transactivation with subsequent inhibition of RhoA activation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation/transactivation) of VEGF associated with opioid
4) Confidence 0.39 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0 Pain Relevance 0.53
MNTX inhibited MS, DAMGO and VEGF induced tyrosine phosphorylation (transactivation) of VEGF receptors 1 and 2.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of VEGF
5) Confidence 0.39 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0.06 Pain Relevance 0.68
The treatment with PO at 12.5 µg/ml reduced the levels of phosphorylated AKT and VEGF expression (intracellular and extracelluar) in HT-1080 cells.
Negative_regulation (reduced) of Phosphorylation (phosphorylated) of VEGF in HT-1080
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2925949 Disease Relevance 0.32 Pain Relevance 0.05
Endostatin also interacts with VEGF signal transduction by reducing VEGF-induced kinase (Erk1/2) phosphorylation [25].
Negative_regulation (reducing) of Phosphorylation (phosphorylation) of VEGF-induced
7) Confidence 0.33 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.17 Pain Relevance 0.16
This study extends these finding by demonstrating that the potent protein tyrosine phosphatase inhibitor, 3,4-Dephostatin, blocks MNTX inhibition of VEGF-induced Src and Akt phosphorylation. 3,4-Dephostatin is known to block the phosphatase activity of PTP-1B, SHPTP-1 and CD45 [20,40,46-48].
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of VEGF-induced
8) Confidence 0.24 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.21 Pain Relevance 0
Further, silencing mTOR blocked VEGF-induced serine, but not threonine Akt phosphorylation.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of VEGF-induced
9) Confidence 0.24 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
This concept represented the rationale for the initiation of a multicenter phase 2 trial of SU5416, a small molecule inhibitor of phosphorylation of VEGF receptors 1 and 2, c-kit, the SCF receptor, and fms-like tyrosine kinase-3 (FLT3) in patients with advanced AML.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of VEGF associated with myeloid leukemia and fibromyalgia
10) Confidence 0.10 Published 2003 Journal Blood Section Abstract Doc Link 12843001 Disease Relevance 0.74 Pain Relevance 0.14
B1 also significantly decreased the ratios of MMP-1 and VEGF to ?
Negative_regulation (decreased) of Phosphorylation (ratios) of VEGF associated with metalloproteinase
11) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.52 Pain Relevance 0.42
Ojima et al. (25) demonstrated that VEGF-induced FLK-1 phosphorylation and its downstream signaling cascade correlated with BRB breakdown and was inhibited by EphA2/ephrinA1 both in vitro and in vivo.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of VEGF
12) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.66 Pain Relevance 0
Moreover, fasudil could inhibit VEGF-induced BRECs [3H]-thymidine incorporation and ERK1/2 phosphorylation, whose activity indicates the proliferative activities of endothelial cells in angiogenic processes [15].
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of VEGF in endothelial cells
13) Confidence 0.04 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.62 Pain Relevance 0

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