INT111549

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 73.60 Quite High
Pain 2 72.08 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 1 99.40 Very High Very High Very High
Myeloid Leukemia 5 97.00 Very High Very High Very High
Leukemia 3 84.36 Quite High
Vomiting 1 74.24 Quite High
Headache 1 73.60 Quite High
Pain 2 72.08 Quite High
Stomach Cancer 42 69.68 Quite High
Gastrointestinal Stromal Tumor 9 64.92 Quite High
Hematologic Neoplasms 1 63.24 Quite High
Cancer 38 61.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a complex formation with SCF the intracellular domain is phosphorylated and new sites are provided for cytoplasmatic messengers e.g.
Phosphorylation (phosphorylated) of SCF
1) Confidence 0.37 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.38 Pain Relevance 0
This concept represented the rationale for the initiation of a multicenter phase 2 trial of SU5416, a small molecule inhibitor of phosphorylation of VEGF receptors 1 and 2, c-kit, the SCF receptor, and fms-like tyrosine kinase-3 (FLT3) in patients with advanced AML.
Phosphorylation (phosphorylation) of SCF associated with myeloid leukemia and fibromyalgia
2) Confidence 0.03 Published 2003 Journal Blood Section Abstract Doc Link 12843001 Disease Relevance 0.75 Pain Relevance 0.15

General Comments

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