INT111554

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal 6
neuronal 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 3 99.64 Very High Very High Very High
Spinal nerve ligature 8 99.32 Very High Very High Very High
allodynia 5 94.08 High High
Hyperalgesia 18 93.48 High High
Dorsal horn 4 92.20 High High
Pain 4 89.24 High High
intrathecal 1 82.28 Quite High
Neuropathic pain 1 60.72 Quite High
IPN 1 55.52 Quite High
withdrawal 3 54.64 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 94.08 High High
Hyperalgesia 18 93.48 High High
Myalgia 3 89.24 High High
Nociception 3 80.16 Quite High
Targeted Disruption 1 75.00 Quite High
Injury 1 65.68 Quite High
Inflammatory Pain 1 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the increases in immunoreactivity for CREB and phosphorylated CREB (p-CREB) in the spinal dorsal horn occur 24 hr, but not 1 week, after the second injection of acidic saline compared with pH 7.2 intramuscular injections.
Positive_regulation (increases) of Regulation (immunoreactivity) of CREB in spinal associated with spinal dorsal horn
1) Confidence 0.50 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.49 Pain Relevance 0.51
Furthermore, using the phosphorylation of cAMP response element-binding protein (pCREB) as a general marker of neuronal activation, a significant increase in pCREB immunoreactivity was observed in SNL rats.
Positive_regulation (increase) of Regulation (immunoreactivity) of pCREB in neuronal associated with spinal nerve ligature
2) Confidence 0.45 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.65 Pain Relevance 1.30
Interestingly, the increases in immunoreactivity for CREB and phosphorylated CREB (p-CREB) in the spinal dorsal horn occur 24 hr, but not 1 week, after the second injection of acidic saline compared with pH 7.2 intramuscular injections.
Positive_regulation (increases) of Regulation (immunoreactivity) of CREB in spinal associated with spinal dorsal horn
3) Confidence 0.44 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.49 Pain Relevance 0.52
Interestingly, the increases in immunoreactivity for CREB and phosphorylated CREB (p-CREB) in the spinal dorsal horn occur 24 hr, but not 1 week, after the second injection of acidic saline compared with pH 7.2 intramuscular injections.
Positive_regulation (increases) of Regulation (immunoreactivity) of p-CREB in spinal associated with spinal dorsal horn
4) Confidence 0.44 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.49 Pain Relevance 0.52

General Comments

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