INT11156

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.03
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TGFA) extracellular space (TGFA) extracellular region (TGFA)
plasma membrane (TGFA) nucleus (TGFA)
Anatomy Link Frequency
pancreas 1
fibroblast 1
TGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 85.36 High High
antagonist 2 73.84 Quite High
palliative 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 99.92 Very High Very High Very High
Cancer 88 99.26 Very High Very High Very High
Recurrence 7 98.72 Very High Very High Very High
Pancreatic Cancer 6 98.12 Very High Very High Very High
Metastasis 12 97.92 Very High Very High Very High
Adenocarcinoma 6 97.72 Very High Very High Very High
Chordoma 131 97.32 Very High Very High Very High
Aggression 2 93.44 High High
Pancreatitis 4 85.36 High High
Malignant Neoplastic Disease 6 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is in vitro evidence that simultaneous overproduction of one of its ligands, transforming growth factor alpha (TGF-alpha), might result in an autocrine loop with an increased proliferation signal.
Gene_expression (overproduction) of transforming growth factor alpha
1) Confidence 0.61 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.53 Pain Relevance 0.15
Abnormalities in expression of two of the known ligands of the EGFR, transforming growth factor alpha and epidermal growth factor, occur frequently in ductal adenocarcinoma of the human pancreas.
Gene_expression (expression) of transforming growth factor alpha in pancreas associated with adenocarcinoma and congenital anomalies
2) Confidence 0.49 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1538276 Disease Relevance 0.42 Pain Relevance 0.07
EGFR pathway is important in proliferation, metastasis, cancer cell invasion, and angiogenesis.50 Blockade of EGFR pathway by cetuximab leads to inhibition of cancer cell proliferation (blockade of cell cycle progression and G1 arrest through an increase in p27kip1 inhibitor of cyclin-dependent kinases),51–53 inhibition of tumor-induced angiogenesis by blockade of production of angiogenic factors (transforming growth factor alpha, VEGF, IL8, basic FGF), inhibition of invasion and metastasis, and potentiation of antitumor activity of cytotoxic drugs and radiation therapy.44,54 There is also evidence of IgG1-mediated antibody directed cell mediated cytotxicity (ADCC).55
Gene_expression (production) of transforming growth factor alpha associated with cancer and metastasis
3) Confidence 0.09 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.54 Pain Relevance 0.04
High levels of transforming growth factor alpha and basic fibroblast growth factor expression were linked to higher rates of recurrence and strong fibronectin expression was also associated with poor prognosis, being thus considered an additional marker of aggressiveness [92].


Gene_expression (expression) of transforming growth factor alpha in fibroblast associated with aggression and recurrence
4) Confidence 0.06 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.54 Pain Relevance 0

General Comments

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