INT11157

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 88
Total Number 94
Disease Relevance 53.73
Pain Relevance 21.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
epithelial cell 7
urine 4
Bladder 2
glands 2
hepatocyte 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 915 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
Nerve growth factor 11 99.92 Very High Very High Very High
Cannabinoid receptor 20 99.76 Very High Very High Very High
Neuropeptide 12 99.08 Very High Very High Very High
cINOD 39 97.80 Very High Very High Very High
Inflammation 277 97.56 Very High Very High Very High
sodium channel 82 97.08 Very High Very High Very High
cytokine 104 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 915 100.00 Very High Very High Very High
Aging 8 99.98 Very High Very High Very High
Natriuresis 3 99.92 Very High Very High Very High
Non-small-cell Lung Cancer 243 99.88 Very High Very High Very High
Cancer 1424 99.80 Very High Very High Very High
Colon Cancer 96 99.52 Very High Very High Very High
Glioma 383 99.48 Very High Very High Very High
Diabetic Foot Ulcer 4 99.44 Very High Very High Very High
Ulcers 246 99.40 Very High Very High Very High
Congenital Anomalies 23 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 6 h exposure to the radiation from 131I decays, mediated mainly by specifically bound EGF, gave a survival value of about 50%.
EGF Binding (bound) of
1) Confidence 0.48 Published 1991 Journal Int. J. Radiat. Biol. Section Abstract Doc Link 1679089 Disease Relevance 0.32 Pain Relevance 0.24
In the present study, we tested the effect of H. pylori culture supernatant (dialyzed to remove molecules smaller than 10 kD) on EGF binding to its receptor and on the proliferative response of human gastric Kato III cells to EGF.
EGF Binding (binding) of
2) Confidence 0.48 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.86 Pain Relevance 0.08
Through binding to its receptor, epidermal growth factor (EGF) accelerates cells migration and triggers epithelial cell proliferation which are both important for the healing of gastroduodenal ulcers.
EGF Binding (binding) of in epithelial cell associated with peptic ulcer
3) Confidence 0.48 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.89 Pain Relevance 0.09
Since ulcer healing requires epithelial cell proliferation and cell migration (re-epithelialization), which are both triggered by EGF binding to its receptor, the alteration in these mechanisms by H. pylori product may be the basis of H. pylori-induced interference with ulcer healing.
EGF Binding (binding) of in epithelial cell associated with ulcers
4) Confidence 0.48 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.85 Pain Relevance 0.06
H. pylori culture supernatant significantly reduced specific binding of EGF to its receptor and reduced EGF-stimulated gastric cell proliferation.
EGF Binding (binding) of
5) Confidence 0.48 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.82 Pain Relevance 0.07
Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis.
epidermal growth factor Spec (like) Binding (binding) of in urine associated with interstitial cystitis
6) Confidence 0.44 Published 2001 Journal Urology Section Title Doc Link 11378043 Disease Relevance 1.34 Pain Relevance 0.52
The cells were, in all cases, incubated for 25 min with about 350 kBq/ml [131I]EGF, which gave a total binding of 3.2-3.5 kBq/10(5) cells.
EGF Binding (binding) of
7) Confidence 0.42 Published 1991 Journal Int. J. Radiat. Biol. Section Abstract Doc Link 1679089 Disease Relevance 0.44 Pain Relevance 0.22
Helicobacter pylori culture supernatant inhibits binding and proliferative response of human gastric cells to epidermal growth factor: implications for H.pylori interference with ulcer healing?
epidermal growth factor Binding (binding) of associated with ulcers
8) Confidence 0.37 Published 1997 Journal Digestion Section Title Doc Link 9243127 Disease Relevance 0.98 Pain Relevance 0.09
Cripto is a 188 amino-acid protein containing a central segment that shares amino-acid sequence homology with epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha).
EGF Binding (homology) of
9) Confidence 0.37 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.64 Pain Relevance 0.31
Effects from non-receptor bound [131I]EGF were analysed after presaturation of the receptors with non-radioactive EGF, and gave no or very small changes in survival.
EGF Spec (analysed) Binding (bound) of
10) Confidence 0.36 Published 1991 Journal Int. J. Radiat. Biol. Section Abstract Doc Link 1679089 Disease Relevance 0.13 Pain Relevance 0.22
In the present study, we tested the effect of H. pylori culture supernatant (dialyzed to remove molecules smaller than 10 kD) on EGF binding to its receptor and on the proliferative response of human gastric Kato III cells to EGF.
EGF Binding (binding) of
11) Confidence 0.36 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.87 Pain Relevance 0.08
Through binding to its receptor, epidermal growth factor (EGF) accelerates cells migration and triggers epithelial cell proliferation which are both important for the healing of gastroduodenal ulcers.
epidermal growth factor Binding (binding) of in epithelial cell associated with peptic ulcer
12) Confidence 0.36 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.89 Pain Relevance 0.09
Pretreatment of IC BUCs with 20 ng/ml of heparin-binding EGF-like growth factor (HB-EGF), which previously has been shown to be decreased in IC urine specimens, also restored IC BUCs to a control phenotype with respect to response to ATP stimulation.
EGF Binding (binding) of in urine associated with interstitial cystitis
13) Confidence 0.35 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16107499 Disease Relevance 1.15 Pain Relevance 1.19
HB-EGF – heparin-binding epidermal growth factor-like growth factor
epidermal growth factor Binding (binding) of
14) Confidence 0.34 Published 2005 Journal BMC Urol Section Body Doc Link PMC1131910 Disease Relevance 0.82 Pain Relevance 0.79
Treatment of IC BUC with heparin-binding epidermal growth factor-like growth factor (HB-EGF), previously shown to be secreted in lower amounts by IC BUC, significantly increased inward potassium current.
EGF Binding (heparin-binding) of in BUC associated with interstitial cystitis
15) Confidence 0.34 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 1.03 Pain Relevance 1.07
Specific binding of biotinylated HBGF2, EGF, or other biologically active molecules (antibiotics, NSAIDs) to implantable collagen may provide a mechanism for positive therapeutic modulation of wound healing, including repair of full-thickness skin wounds with cultured cell-collagen composite grafts.
EGF Binding (binding) of in skin associated with injury, wound healing and cinod
16) Confidence 0.34 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0.19 Pain Relevance 0.10
Binding of biotinylated HBGF2 and EGF was specific (*, P less than 0.05), proportional to the concentration of biotinylated collagen, and resistant to ionic (NaCl) displacement.
EGF Binding (Binding) of
17) Confidence 0.34 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0.06
Biotinylation of collagen and the growth factors allows immobilization of HBGF2 and EGF by high affinity binding of tetravalent avidin.
EGF Binding (binding) of
18) Confidence 0.34 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0
Further fine-tuning of this control mechanism may occur via interactions within the EGF system itself whereby, for example, EGF can control EGFR expression and vice versa, in autocrine fashion [50].
EGF Binding (interactions) of
19) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.64 Pain Relevance 0.64
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
epidermal growth factor Binding (binding) of in epithelial cell associated with cystitis and interstitial cystitis
20) Confidence 0.33 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 0.91 Pain Relevance 0.44

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