INT11158

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 8
Speculated 2
Reported most in Body
Documents 165
Total Number 167
Disease Relevance 131.26
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
lung 12
salivary gland 10
cervix 8
brain 4
platelet 4
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 37 99.32 Very High Very High Very High
Inflammation 91 98.92 Very High Very High Very High
Chronic pancreatitis 3 98.84 Very High Very High Very High
lidocaine 11 98.64 Very High Very High Very High
Endocannabinoid 32 97.92 Very High Very High Very High
antagonist 39 96.48 Very High Very High Very High
palliative 80 93.68 High High
positron emission tomography 101 92.80 High High
Pain 94 92.52 High High
COX2 1 91.88 High High
Disease Link Frequency Relevance Heat
Cancer 5557 100.00 Very High Very High Very High
Colon Cancer 342 100.00 Very High Very High Very High
Colorectal Cancer 302 100.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 598 99.98 Very High Very High Very High
Endometrial Cancer 306 99.98 Very High Very High Very High
Stomach Cancer 70 99.98 Very High Very High Very High
Esophageal Cancer 38 99.98 Very High Very High Very High
Non-small-cell Lung Cancer 823 99.96 Very High Very High Very High
Triple Negative Breast Cancer 7 99.96 Very High Very High Very High
Breast Cancer 1118 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined an archival series of cases of pancreatic pathology for expression of the EGFR using the anti-EGFR antiserum 12E and found that there is almost ubiquitous overexpression of EGFR in pancreatic cancer and in chronic pancreatitis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.70 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1538276 Disease Relevance 0.45 Pain Relevance 0.10
EGFR overexpression is related to a poorer prognosis and a more aggressive behaviour of the disease but its overall prognostic value has not been completely established [3,6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with aggression and disease
2) Confidence 0.70 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 0.84 Pain Relevance 0.17
This could be related to the presence of EGFR mutations, lack of KRAS mutations, or overexpression of EGFR as measured by fluorescent in-situ hybridization (FISH) analysis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR
3) Confidence 0.69 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721286 Disease Relevance 0.74 Pain Relevance 0
High levels of EGFR expression was associated with balanced polysomy (similar high level gains in EGFR gene and chr 7) and EGFR gene amplification (unbalanced gain of EGFR gene).
Positive_regulation (levels) of Gene_expression (expression) of EGFR
4) Confidence 0.69 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.93 Pain Relevance 0
Well differentiated tumors had a higher level of EGFR expression compared to poorly differentiated tumors.
Positive_regulation (level) of Gene_expression (expression) of EGFR associated with cancer
5) Confidence 0.69 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.97 Pain Relevance 0
EGFR is overexpressed in many colorectal tumors; although some studies have shown inconsistent findings, the levels of EGFR expression are related to prognosis, with higher expression levels correlating with shorter survival times and greater metastatic potential (Nicholson et al 2001; Spano et al 2005).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with colorectal cancer
6) Confidence 0.69 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.57 Pain Relevance 0
Additionally, epithelial EGFR expression is increased in bronchial biopsies from smokers with [10,11] and without [11,12] COPD compared to non-smokers.
Positive_regulation (increased) of Gene_expression (expression) of EGFR associated with pulmonary disease and nicotine addiction
7) Confidence 0.69 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.96 Pain Relevance 0.03
Neither EGFR gene amplification nor EGFR overexpression was associated with survival in this study.
Neg (Neither) Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR
8) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.88 Pain Relevance 0
Overexpression of EGFR in astrocytomas can also occur without gene amplification [8,28,32,37,39], suggesting other mechanisms at transcriptional and translational levels.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of EGFR associated with anaplastic astrocytoma
9) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 1.01 Pain Relevance 0
most notably EGFR, are frequently overexpressed, and this aberrant expression
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR
10) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.38 Pain Relevance 0
This is in accordance with the data of Ellis et al. [10], in which biopsy specimens of acanthosis nigricans, seborrheic keratoses, and acrochordons showed intense staining for EGF receptors in all epidermal layers, except the stratum corneum, showing that EGFR overexpression may be one of the concomitant pathognomonic mechanisms responsible for sudden multiple eruption of SK.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with acanthosis and keratosis
11) Confidence 0.69 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2820021 Disease Relevance 0.98 Pain Relevance 0
Our study, even demonstrating similar expression profiles of EGFR and HER-2 in cancerous and unaffected tissues, confirmed that EGFR is overexpressed in SCC, as compared to ADC samples, whereas HER-2 displays an opposite behaviour [25, 26].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with adenocarcinoma and skin cancer
12) Confidence 0.69 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.44 Pain Relevance 0
Overexpression of EGFR and HER-2 receptors in NSCLC samples has been reported in many series, ranging from 43 to 89% and from 16 to 57% of tumors and patients, respectively (reviewed in [24]).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of EGFR associated with cancer and non-small-cell lung cancer
13) Confidence 0.69 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.59 Pain Relevance 0
The overexpression of EGFR has been demonstrated in a number of human tumor types, including head-and-neck cancers, colon cancer, breast cancer, gliomas, lung cancer and pancreatic cancer [23,24].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR in lung associated with lung cancer, cancer, pancreatic cancer, breast cancer, colon cancer and glioma
14) Confidence 0.68 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266352 Disease Relevance 1.18 Pain Relevance 0
Activation of the EGFR pathway is particularly common in colorectal cancers [19-22] and overexpression of EGFR correlates with more aggressive disease and poor prognosis [23-26].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with colon cancer and disease
15) Confidence 0.68 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.65 Pain Relevance 0.11
The EGFR receptor is often overexpressed in NSCLCs, making cetuximab an attractive drug.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR receptor
16) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 1.03 Pain Relevance 0
EGFR is overexpressed in about 40% to 80% of NSCLC.28 Downstream signaling by the activated EGFR can be abrogated by small molecule inhibitors, such as erlotinib and gefitinib or by monoclonal antibodies directed towards the extracellular domain of EGFR, such as cetuximab.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with non-small-cell lung cancer
17) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.66 Pain Relevance 0.07
In a phase II trial by Kim et al 47 patients with refractory NSCLC or who had disease recurrence within 3 months after chemotherapy and tumor overexpression of EGFR of at least 1+ by IHC received cetuximab with docetaxel (75 mg/m2 iv every 3 weeks).92 Thirteen patients (28%) achieved PR and 8 (17%) had SD.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with cancer, non-small-cell lung cancer, disease and recurrence
18) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 1.09 Pain Relevance 0
If these pathways are dysregulated, such as in the case of EGFR overexpression, alterations in cellular growth, survival, angiogenesis and metastases may occur.11–18
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with metastasis
19) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.66 Pain Relevance 0
The proposed development of colorectal cancer evolves from the progressive accumulation of genetic and epigenetic alterations resulting in the transformation of normal colonic mucosa to invasive adenocarcinoma.19 EGFR has been implicated in the initiation of colorectal tumors and has also been noted to be frequently overexpressed in CRC.5,20 The prognostic significance of EGFR in CRC remains unclear.6,20

Panitumumab pharmacology and pharmacokinetics

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with adenocarcinoma and colorectal cancer
20) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.96 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox