INT111584

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.68
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 2
synapse 2
frontal cortex 2
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 254 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
Dynorphin 1 94.12 High High
Desipramine 6 92.92 High High
agonist 10 86.80 High High
cerebral cortex 2 83.92 Quite High
Ventral tegmentum 30 76.40 Quite High
Nucleus accumbens 10 73.36 Quite High
Opioid 1 69.36 Quite High
Hippocampus 6 66.80 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 99.58 Very High Very High Very High
Targeted Disruption 2 98.42 Very High Very High Very High
Cognitive Disorder 15 85.24 High High
Attention Deficit Hyperactivity Disorder 31 66.84 Quite High
Pressure Volume 2 Under Development 1 54.88 Quite High
Affective Disorder 2 34.96 Quite Low
Lumbar Puncture Related Headaches 1 29.20 Quite Low
Depression 25 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Endometriosis (extended) 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, as found previously in DOCA-treated rats, there were increased enkephalin (ENK)-mRNA and decreased dopamine transporter (DAT) binding levels throughout the striatum in Lasix+salt and decreased ENK-mRNA in Lasixnosalt rats versus Vehicle.
Positive_regulation (increased) of Negative_regulation (decreased) of DAT in striatum associated with dopamine and enkephalin
1) Confidence 0.47 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 12845226 Disease Relevance 0.05 Pain Relevance 0.58
Therefore, MPH-induced blockade of the DAT increases dopamine concentrations in the synapse and extracellular space [56].
Positive_regulation (increases) of Negative_regulation (blockade) of DAT in synapse associated with dopamine
2) Confidence 0.29 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.15 Pain Relevance 0.45
When 10 nM E2 was added for only the last 5 min of the uptake assay, it dramatically inhibited DAT activity, more effectively than during the 30-min assay; uptake was completely reversed with only a 5-min hormone exposure.
Positive_regulation (When) of Negative_regulation (inhibited) of DAT
3) Confidence 0.26 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0.20
Using NET knock-out mice, it was shown that DA uptake into frontal cortex synaptosomes is the result of NET and not DAT blockade, because a selective concentration of GBR12909 did not block DA uptake into frontal cortex synaptosomes from NET knock-out mice [67].
Positive_regulation (result) of Neg (not) Negative_regulation (blockade) of DAT in frontal cortex associated with targeted disruption, dopamine and urological neuroanatomy
4) Confidence 0.06 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.47 Pain Relevance 1.08

General Comments

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