INT11159

Context Info Confidence 0.78 First Reported 1991 Last Reported 2011 Negated 21 Speculated 19 Reported most in Body Documents 698 Total Number 717 Disease Relevance 548.93 Pain Relevance 25.69

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR) endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)

Anatomy Link Frequency lung 15 GBM 12 skin 10 salivary gland 6 head 6 EGFR (Homo sapiens) EGFR - R521K (1)

Pain Link Frequency Relevance Heat antagonist 312 100.00 cocaine 48 100.00 Nerve growth factor 44 100.00 addiction 69 99.92 cva 374 99.66 cytokine 207 98.96 palliative 429 98.92 Hippocampus 26 98.90 cINOD 837 98.88 Chronic pancreatitis 8 98.84

Disease Link Frequency Relevance Heat Cancer 22515 100.00 Apoptosis 3892 100.00 Colon Cancer 2582 100.00 Cholangiocarcinoma 1787 100.00 Colorectal Cancer 1696 100.00 Triple Negative Breast Cancer 29 100.00 Advanced Or Metastatic Breast Cancer 2457 99.98 Endometrial Cancer 921 99.98 Stomach Cancer 285 99.98 Esophageal Cancer 218 99.98

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The first feature common to both malignancies is that EGFR expression is quite common in malignant mesothelioma[10-12].

Gene_expression (expression) of EGFR associated with malignant neoplastic disease and lung cancer

1) Confidence 0.78 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 2.28 Pain Relevance 0.10

Interestingly in this erlotinib trial, the high EGFR expressing tumor group experienced a 2-fold longer survival, but study did not interrogate tumors for EGFR mutations.

Gene_expression (expressing) of EGFR associated with cancer

2) Confidence 0.78 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 1.80 Pain Relevance 0

We have examined an archival series of cases of pancreatic pathology for expression of the EGFR using the anti-EGFR antiserum 12E and found that there is almost ubiquitous overexpression of EGFR in pancreatic cancer and in chronic pancreatitis.

Gene_expression (overexpression) of EGFR associated with pancreatic cancer and chronic pancreatitis

3) Confidence 0.78 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1538276 Disease Relevance 0.45 Pain Relevance 0.10

We have examined an archival series of cases of pancreatic pathology for expression of the EGFR using the anti-EGFR antiserum 12E and found that there is almost ubiquitous overexpression of EGFR in pancreatic cancer and in chronic pancreatitis.

Gene_expression (expression) of EGFR associated with pancreatic cancer and chronic pancreatitis

4) Confidence 0.78 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1538276 Disease Relevance 0.45 Pain Relevance 0.09

EGFR protein expression, as evaluated by immunohistochemistry, does not correlate with response [2,4,11] and only specific treatment-induced skin rash seems associated with tumor response and progression-free survival [2].

Gene_expression (expression) of EGFR protein in skin associated with exanthema and cancer

5) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.47 Pain Relevance 0

Six of thirty-five (2%) partial responses were reported in patients with low expression of EGFR (<1%) and 4/51 (8%) in patients with negative levels of EGFR, and stable disease occurred in 11/35 (31%) versus 15/51 (29%), with a disease control rate of 37% versus 39%.

Gene_expression (expression) of EGFR associated with disease

6) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 1.06 Pain Relevance 0.06

To date in all trials with panitumumab EGFR immunohistochemistry expression was assessed.

Gene_expression (expression) of EGFR

7) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 0.75 Pain Relevance 0

A large, phase III, multicenter, pivotal trial (study 408) has randomized patients with oxaliplatin and irinotecan-refractory EGFR-expressing metastatic colorectal cancer between best supportive care (BSC) and BSC plus panitumumab at a dose of 6 mg/m2 every 2 weeks (Van Cutsem et al. 2007).

Gene_expression (expressing) of EGFR associated with colon cancer

8) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 1.10 Pain Relevance 0

More information about the role of EGFR inhibition as a first-line option in colorectal cancer should come from the Crystal study, a large multicenter study in which 1212 patients with previously untreated metastatic colorectal cancer expressing EGFR have been randomized to receive FOLFIRI with or without cetuximab; preliminary data are expected in 2007.

Gene_expression (expressing) of EGFR associated with colon cancer

9) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 0.33 Pain Relevance 0

Six of thirty-five (2%) partial responses were reported in patients with low expression of EGFR (<1%) and 4/51 (8%) in patients with negative levels of EGFR, and stable disease occurred in 11/35 (31%) versus 15/51 (29%), with a disease control rate of 37% versus 39%.

Gene_expression (expression) of EGFR associated with disease

10) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 1.08 Pain Relevance 0.06

Overexpression of the human epidermal growth factor receptor (HER) family of oncoproteins, HER1/epidermal growth factor receptor (EGFR) and HER2, has been described in approximately 70% of salivary gland carcinomas including MEC and adenoid cystic carcinoma [4] but few studies have evaluated the therapeutic relevance of an anti-EGFR/HER2 strategy in these neoplasms.

Gene_expression (Overexpression) of HER in salivary gland associated with cancer, mucoepidermoid carcinoma, adenoid cystic carcinoma and carcinoma

11) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 1.49 Pain Relevance 0

Immunohistochemical studies demonstrated different degrees of EGFR expression in several salivary gland carcinomas, including MECs and adenoid cystic carcinomas (ACCs).

Gene_expression (expression) of EGFR in salivary gland associated with adenoid cystic carcinoma and carcinoma

12) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 0.80 Pain Relevance 0.19

Overexpression of the human epidermal growth factor receptor (HER) family of oncoproteins, HER1/epidermal growth factor receptor (EGFR) and HER2, has been described in approximately 70% of salivary gland carcinomas including MEC and adenoid cystic carcinoma [4] but few studies have evaluated the therapeutic relevance of an anti-EGFR/HER2 strategy in these neoplasms.

Gene_expression (Overexpression) of epidermal growth factor receptor in salivary gland associated with cancer, mucoepidermoid carcinoma, adenoid cystic carcinoma and carcinoma

13) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 1.56 Pain Relevance 0

EGFR overexpression is related to a poorer prognosis and a more aggressive behaviour of the disease but its overall prognostic value has not been completely established [3,6].

Gene_expression (overexpression) of EGFR associated with aggression and disease

14) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 0.84 Pain Relevance 0.17

Overexpression of the human epidermal growth factor receptor (HER) family of oncoproteins, HER1/epidermal growth factor receptor (EGFR) and HER2, has been described in approximately 70% of salivary gland carcinomas including MEC and adenoid cystic carcinoma [4] but few studies have evaluated the therapeutic relevance of an anti-EGFR/HER2 strategy in these neoplasms.

Gene_expression (Overexpression) of EGFR in salivary gland associated with cancer, mucoepidermoid carcinoma, adenoid cystic carcinoma and carcinoma

15) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 1.56 Pain Relevance 0

High levels of EGFR expression was associated with balanced polysomy (similar high level gains in EGFR gene and chr 7) and EGFR gene amplification (unbalanced gain of EGFR gene).

Gene_expression (expression) of EGFR

16) Confidence 0.78 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.92 Pain Relevance 0

In the BR.21 study, EGFR expression in the erlotinib treated group was associated with a better response without a survival advantage (Tsao et al 2005).

Gene_expression (expression) of EGFR

17) Confidence 0.78 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.41 Pain Relevance 0

EGFR is expressed on the keratinocytes, sebaceous gland cells, and the outer sheath of hair follicles (Lee et al 2004).

Gene_expression (expressed) of EGFR in keratinocytes

18) Confidence 0.78 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.64 Pain Relevance 0.04

This could be related to the presence of EGFR mutations, lack of KRAS mutations, or overexpression of EGFR as measured by fluorescent in-situ hybridization (FISH) analysis.

Gene_expression (overexpression) of EGFR

19) Confidence 0.78 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721286 Disease Relevance 0.74 Pain Relevance 0

Well differentiated tumors had a higher level of EGFR expression compared to poorly differentiated tumors.

Gene_expression (expression) of EGFR associated with cancer

20) Confidence 0.78 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.97 Pain Relevance 0

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