INT111594

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 8.69
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOSTRIN) cytoplasmic membrane-bounded vesicle (NOSTRIN) plasma membrane (NOSTRIN)
cytoskeleton (NOSTRIN) cytoplasm (NOSTRIN)
Anatomy Link Frequency
neuronal 2
endothelial cells 2
tendon 2
bladder 2
nucleus 2
NOSTRIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 20 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Paracetamol 12 99.80 Very High Very High Very High
Leflunomide 10 99.42 Very High Very High Very High
Inflammation 138 97.52 Very High Very High Very High
interstitial cystitis 5 97.44 Very High Very High Very High
endometriosis 84 96.68 Very High Very High Very High
Osteoarthritis 149 96.08 Very High Very High Very High
medulla 2 96.00 Very High Very High Very High
Hippocampus 6 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 180 100.00 Very High Very High Very High
Shock 13 99.74 Very High Very High Very High
Apoptosis 135 98.28 Very High Very High Very High
Interstitial Cystitis 5 97.44 Very High Very High Very High
Endometriosis (extended) 96 96.68 Very High Very High Very High
Osteoarthritis 149 96.08 Very High Very High Very High
Urological Neuroanatomy 6 95.32 Very High Very High Very High
Pain 35 91.72 High High
Cystitis 1 90.12 High High
Injury 24 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial nitric oxide synthase (eNOS) gene expression was increased by 67% ± 19% (p = 0.002) and 66% ± 16% (p = 0.039) in the CR and CREX groups, respectively (Figure 1D).
Positive_regulation (increased) of Gene_expression (expression) of Endothelial nitric oxide synthase
1) Confidence 0.32 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
PLC-induced dilatative adaptation, and growth was found associated with increased inducible nitric oxide synthase and reduced arterial vascular endothelial growth factor and intracellular adhesion molecule-1 expression.
Positive_regulation (increased) of Gene_expression (expression) of nitric oxide synthase
2) Confidence 0.14 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.07 Pain Relevance 0
Increased expression of endothelial NO synthase has been reported throughout the menstrual cycle in the endometrium of women with endometriosis [139].

2.11 Nitric oxide synthase and the ovary

Positive_regulation (Increased) of Gene_expression (expression) of endothelial NO synthase in endometrium associated with endometriosis
3) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.64 Pain Relevance 0.43
The Western blot analysis on human umbilical vein endothelial cells indicated that VOA increased the expression of endothelium nitric oxide synthase.
Positive_regulation (increased) of Gene_expression (expression) of nitric oxide synthase in endothelium
4) Confidence 0.10 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14508237 Disease Relevance 0.16 Pain Relevance 0.24
Follicular fluid NO seems to be produced by either endothelial NO synthase or induced NO synthase.
Neg (NO) Positive_regulation (induced) of Gene_expression (produced) of endothelial NO synthase
5) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.16 Pain Relevance 0.03
This was also previously observed in induced nitric oxide synthase and nitrotyrosine expression [35].
Positive_regulation (induced) of Gene_expression (expression) of nitric oxide synthase
6) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.47 Pain Relevance 0.08
Furthermore, leflunomide inhibited the APAP-mediated increased expression of inducible nitric oxide synthase and prevented the formation of peroxynitrite, as judged from the absence of hepatic nitrotyrosine adducts.
Positive_regulation (increased) of Gene_expression (expression) of nitric oxide synthase associated with paracetamol and leflunomide
7) Confidence 0.06 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.47 Pain Relevance 1.18
has been a potent inducer of reactive oxygen species, including nitric oxide and inflammatory mediators such as prostaglandin E2, via enhanced expression of the enzymes inducible nitric oxide synthase and COX-2, respectively [15,16].
Positive_regulation (inducible) of Gene_expression (expression) of nitric oxide synthase associated with inflammatory mediators
8) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.59 Pain Relevance 0.29
-induced inducible nitric oxide synthase and COX-2 expression and activity, which further resulted in the reduced nitric oxide and prostaglandin E2 synthesis [15,16].
Positive_regulation (induced) of Gene_expression (expression) of nitric oxide synthase
9) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.54 Pain Relevance 0.27
has been a potent inducer of reactive oxygen species, including nitric oxide and inflammatory mediators such as prostaglandin E2, via enhanced expression of the enzymes inducible nitric oxide synthase and COX-2, respectively [15,16].
Positive_regulation (enhanced) of Gene_expression (expression) of nitric oxide synthase associated with inflammatory mediators
10) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.59 Pain Relevance 0.29
Defining the molecular mechanism of EGCG's efficacy in regulating inducible nitric oxide synthase expression, the results showed that EGCG inhibits IL-1?
Positive_regulation (inducible) of Gene_expression (expression) of nitric oxide synthase
11) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.54 Pain Relevance 0.27
-induced inducible nitric oxide synthase and COX-2 expression and activity, which further resulted in the reduced nitric oxide and prostaglandin E2 synthesis [15,16].
Positive_regulation (inducible) of Gene_expression (expression) of nitric oxide synthase
12) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.53 Pain Relevance 0.26
has been a potent inducer of reactive oxygen species, including nitric oxide and inflammatory mediators such as prostaglandin E2, via enhanced expression of the enzymes inducible nitric oxide synthase and COX-2, respectively [15,16].
Positive_regulation (inducer) of Gene_expression (expression) of nitric oxide synthase associated with inflammatory mediators
13) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.67 Pain Relevance 0.31
M) have cardioprotective effects by inducing endothelial nitric-oxide synthase gene expression and increasing nitric oxide levels in cultured endothelial cells [46].
Positive_regulation (inducing) of Gene_expression (expression) of endothelial nitric-oxide synthase gene in endothelial cells
14) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.20 Pain Relevance 0.10
Based on the results of animal studies in our laboratory, it appears that the mechanism of shock waves first stimulates the early expression of angiogenesis-related growth factors including eNOS (endothelial nitric oxide synthase), VEGF (vessel endothelial growth factor) and PCNA (proliferating cell nuclear antigen), then induces the ingrowth of neovascularization that improves blood supply and increases cell proliferation and eventual tissue regeneration to repair tendon or bone tissues.
Positive_regulation (stimulates) of Gene_expression (expression) of endothelial nitric oxide synthase in tendon associated with shock
15) Confidence 0.03 Published 2003 Journal Chang Gung Med J Section Abstract Doc Link 12846521 Disease Relevance 1.37 Pain Relevance 0.33
Altered inducible nitric oxide synthase expression and nitric oxide production in the bladder of cats with feline interstitial cystitis.
Positive_regulation (inducible) of Gene_expression (expression) of nitric oxide synthase in bladder associated with interstitial cystitis
16) Confidence 0.03 Published 2005 Journal J. Urol. Section Title Doc Link 15643277 Disease Relevance 0.37 Pain Relevance 0.45
However, inhibition of Rho and Rho kinase activity and stimulation the PI3 kinase/Akt pathway may lead to increased in endothelial nitric oxide synthase (eNOS) expression and activation was considered one of the mechanisms (28-30).
Positive_regulation (increased) of Gene_expression (expression) of nitric oxide synthase
17) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2858830 Disease Relevance 0.74 Pain Relevance 0.04
The free radical scavenger and antioxidant melatonin was used in the therapy of rats experimentally stung with crude venom of Pelagia noctiluca and suffering from acute paw inflammation characterized by lipid peroxidation and occurrence of polymorphonuclear neutrophils; the venom was observed to promote the expression of inducible nitric oxide synthase and the activation of the nuclear enzymes and the administration of melatonin reduced remarkably the inflammation [166].
Positive_regulation (inducible) of Gene_expression (expression) of nitric oxide synthase in polymorphonuclear neutrophils associated with inflammation
18) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866479 Disease Relevance 0.40 Pain Relevance 0.10
Adenovirus-mediated nitric oxide synthase gene transfer into the nucleus tractus solitarius in conscious rats.
Positive_regulation (transfer) of Gene_expression (transfer) of nitric oxide synthase gene in nucleus
19) Confidence 0.02 Published 2004 Journal Methods Mol. Biol. Section Title Doc Link 15199246 Disease Relevance 0 Pain Relevance 0.13
Enhanced expression of neuronal nitric oxide synthase (nNOS) a subtype of the NO synthesizing enzyme nitric oxide synthase (NOS) has been noted following exposure to pulsed MF [62].
Positive_regulation (Enhanced) of Gene_expression (expression) of nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
20) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644491 Disease Relevance 0.10 Pain Relevance 0.21

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