INT1116

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 28
Speculated 6
Reported most in Abstract
Documents 103
Total Number 109
Disease Relevance 27.66
Pain Relevance 33.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 56
blood 7
heart 5
brain 3
myocardium 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 92 100.00 Very High Very High Very High
narcan 74 100.00 Very High Very High Very High
Clonidine 69 100.00 Very High Very High Very High
epidural 64 100.00 Very High Very High Very High
cva 49 100.00 Very High Very High Very High
Catecholamine 35 100.00 Very High Very High Very High
bradykinin 34 100.00 Very High Very High Very High
Intracerebroventricular 23 100.00 Very High Very High Very High
noradrenaline 20 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 90 100.00 Very High Very High Very High
Hemorrhage 42 100.00 Very High Very High Very High
Stress 10 100.00 Very High Very High Very High
Stroke 6 100.00 Very High Very High Very High
Cv Unclassified Under Development 5 100.00 Very High Very High Very High
Sepsis 77 99.92 Very High Very High Very High
Dysmenorrhea 4 99.68 Very High Very High Very High
Hypotension 20 99.58 Very High Very High Very High
Natriuresis 27 99.52 Very High Very High Very High
Bordatella Infection 8 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data further confirm the independent control of active and inactive renin in the rat.
Neg (independent) Regulation (control) of renin
1) Confidence 0.62 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 6756693 Disease Relevance 0.09 Pain Relevance 0.08
These results suggest the possible independence of in vivo regulation of active and inactive renin in the rat.
Regulation (regulation) of renin
2) Confidence 0.61 Published 1982 Journal Hypertension Section Abstract Doc Link 7040241 Disease Relevance 0.15 Pain Relevance 0.41
Potentiation of beta-adrenergic affects on plasma renin concentration by pentobarbital anesthesia.
Regulation (affects) of renin in plasma associated with anesthesia
3) Confidence 0.61 Published 1983 Journal Ren Physiol Section Title Doc Link 6316431 Disease Relevance 0.09 Pain Relevance 0.30
The present results indicate that opioid receptors are involved in the plasma adrenaline response to submaximal exercise, but not in the regulation of systolic blood pressure, heart rate, plasma noradrenaline, renin activity and plasma aldosterone.
Neg (not) Regulation (regulation) of renin in plasma associated with noradrenaline and opioid receptor
4) Confidence 0.61 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 3055074 Disease Relevance 0 Pain Relevance 0.50
These results, taken with previous publications, emphasize that the effects of lead on plasma renin even within a single species are greatly affected by the timing of the exposure.
Regulation (effects) of renin in plasma
5) Confidence 0.60 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6338501 Disease Relevance 0.06 Pain Relevance 0.07
Acute sodium-driven renin regulation seems independent of RSNA and nNOS under the present conditions.
Regulation (regulation) of renin
6) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18234741 Disease Relevance 0.31 Pain Relevance 0.06
Together, these findings suggest that brain FMRFamide-activated sodium channels may be involved in the mechanism of salt-sensitive hypertension through regulation of the brain renin-angiotensin system.
Regulation (regulation) of renin in brain associated with hypertension and sodium channel
7) Confidence 0.58 Published 2000 Journal Hypertension Section Abstract Doc Link 10642339 Disease Relevance 0.23 Pain Relevance 0.25
It did not affect baseline plasma adrenocorticotropic hormone levels and renin activity, but decreased plasma corticosterone levels.
Neg (not) Regulation (affect) of renin in plasma
8) Confidence 0.56 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392854 Disease Relevance 0.59 Pain Relevance 0.46
Effects of prazosin on blood pressure and plasma renin activity during onset and withdrawal of action in the anaesthetized rat.
Regulation (Effects) of plasma renin in blood associated with anesthesia and withdrawal
9) Confidence 0.54 Published 1979 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 572749 Disease Relevance 0.15 Pain Relevance 0.22
Effect of pertussis toxin on the adrenergic regulation of plasma renin activity.
Regulation (regulation) of renin in plasma associated with bordatella infection
10) Confidence 0.49 Published 1984 Journal Life Sci. Section Title Doc Link 6090844 Disease Relevance 0.27 Pain Relevance 0.13
Other factors also affect renin profiling.
Regulation (affect) of renin
11) Confidence 0.49 Published 1978 Journal Geriatrics Section Abstract Doc Link 624453 Disease Relevance 0.57 Pain Relevance 0.13
Naloxone had no effect on plasma renin activity (PRA), plasma atrial natriuretic peptide (ANP), or concentrations of Na+ and K+ in plasma.
Neg (no) Regulation (effect) of renin in plasma associated with natriuresis and narcan
12) Confidence 0.46 Published 1991 Journal Clin Exp Hypertens A Section Abstract Doc Link 2022070 Disease Relevance 0.60 Pain Relevance 0.45
Hemorrhage produced equivalent changes in blood pressure and plasma renin titer in the two groups.
Regulation (changes) of renin in plasma associated with cv unclassified under development and cva
13) Confidence 0.45 Published 1978 Journal Nephron Section Abstract Doc Link 745630 Disease Relevance 0.52 Pain Relevance 0.14
[Release mechanisms of inactive renin from rat renal cortical slices: role of the submandibular gland].
Regulation (role) of renin in submandibular gland
14) Confidence 0.45 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Title Doc Link 2118863 Disease Relevance 0 Pain Relevance 0.08
The role of the renin-angiotensin system in normotensive and hypertensive rats with varying renin status.
Regulation (role) of renin associated with anesthesia and hypertension
15) Confidence 0.45 Published 1987 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 3555376 Disease Relevance 0.28 Pain Relevance 0.10
The effects of single intramuscular injections of prazosin, 0.1 mg/kg, upon blood pressure, heart rate and plasma renin activity, were studied, over 24 h, in groups of anaesthetized rats, control rats receiving 0.9% saline. 2.
Regulation (effects) of plasma renin in blood
16) Confidence 0.45 Published 1979 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 572749 Disease Relevance 0.12 Pain Relevance 0.09
Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium.
Regulation (Effect) of renin in plasma
17) Confidence 0.45 Published 1997 Journal Hypertension Section Title Doc Link 9260990 Disease Relevance 0 Pain Relevance 0.07
Thus, the dipsogenic response to administration of 5-HTP to rats is dependent on both the renin-angiotensin system and an intact dopaminergic pathway.
Regulation (dependent) of renin-angiotensin
18) Confidence 0.45 Published 1981 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7015366 Disease Relevance 0.45 Pain Relevance 0.24
The effects of combined renin inhibition and converting enzyme inhibition on mean arterial pressure and the plasma renin-angiotensin system were studied in conscious rats.
Regulation (effects) of plasma renin in plasma
19) Confidence 0.45 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.16 Pain Relevance 0
The effects of combined renin inhibition and converting enzyme inhibition on mean arterial pressure and the plasma renin-angiotensin system were studied in conscious rats.
Regulation (effects) of renin in plasma
20) Confidence 0.45 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.14 Pain Relevance 0

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