INT11160

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 6
Speculated 5
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 22.05
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
arms 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 100.00 Very High Very High Very High
Inflammation 47 96.80 Very High Very High Very High
cytokine 8 96.76 Very High Very High Very High
Chronic pancreatitis 1 94.88 High High
palliative 13 83.64 Quite High
backache 3 80.44 Quite High
Pain 26 79.88 Quite High
imagery 55 78.84 Quite High
agonist 5 77.32 Quite High
Angina 7 70.48 Quite High
Disease Link Frequency Relevance Heat
Disease 325 100.00 Very High Very High Very High
Colon Cancer 126 100.00 Very High Very High Very High
Cancer 975 99.98 Very High Very High Very High
Ovarian Cancer 87 99.84 Very High Very High Very High
Breast Cancer 599 99.80 Very High Very High Very High
Pulmonary Disease 126 99.54 Very High Very High Very High
Apoptosis 88 99.36 Very High Very High Very High
Mouth Cancer 19 99.14 Very High Very High Very High
Nicotine Addiction 325 99.00 Very High Very High Very High
Metaplasia 70 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, it can now be inferred that smoking cessation results in decreased epithelial mucin stores, proliferation, and squamous cell metaplasia, in large airways of patients with COPD, but that it does not affect EGFR expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of EGFR associated with pulmonary disease, nicotine addiction and metaplasia
1) Confidence 0.62 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 2.05 Pain Relevance 0
With the activity of panitumumab in colorectal cancer having been confirmed, subsequent studies were performed to assess the dependence of EGFR expression on clinical outcome (Berlin et al 2007; Hecht et al 2007a; Mitchell et al 2007).
Regulation (dependence) of Gene_expression (expression) of EGFR associated with addiction and colon cancer
2) Confidence 0.60 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721355 Disease Relevance 0.45 Pain Relevance 0.05
In order to investigate whether the EGFR mutations are sensitive to the EGFR inhibitor Erlotinib, COS-7 cells transfected with mutant EGFR and treated with various concentrations (0.002 to 2.0 ?
Spec (whether) Regulation (sensitive) of Spec (whether) Gene_expression (mutations) of EGFR
3) Confidence 0.45 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.05 Pain Relevance 0
We have examined an archival series of cases of pancreatic pathology for expression of the EGFR using the anti-EGFR antiserum 12E and found that there is almost ubiquitous overexpression of EGFR in pancreatic cancer and in chronic pancreatitis.
Spec (examined) Regulation (series) of Gene_expression (expression) of EGFR associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.45 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1538276 Disease Relevance 0.46 Pain Relevance 0.09
The intensity of EGFR staining, however, did not affect response rate or survival.
Neg (not) Regulation (affect) of Gene_expression (staining) of EGFR
5) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.97 Pain Relevance 0
No patient had both KRAS and EGFR mutation.
Neg (No) Regulation (had) of Gene_expression (mutation) of EGFR
6) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 1.31 Pain Relevance 0.06
Clearly, the selection of patients based on EGFR expression is no longer sufficient, inasmuch as response rates appear independent of EGFR staining intensity (Cunningham et al 2004; Lenz et al 2006).
Regulation (based) of Gene_expression (expression) of EGFR
7) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.64 Pain Relevance 0
, increase EGFR expression [33], our observation that there is no difference in EGFR expression between ex- and current smokers may be related to the persistence of bronchial inflammation [16,17] in ex-smokers with COPD.
Neg (no) Regulation (difference) of Gene_expression (expression) of EGFR associated with pulmonary disease, nicotine addiction and inflammation
8) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.16 Pain Relevance 0.20
anomalous EGFR expression; in this case, scrutiny of the structure of EGFR and
Regulation (scrutiny) of Gene_expression (expression) of EGFR
9) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.58 Pain Relevance 0
involved in anti-EGFR therapy as well as define relationships between the overexpression
Regulation (involved) of Gene_expression (therapy) of EGFR
10) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.61 Pain Relevance 0
anomalous EGFR expression; in this case, scrutiny of the structure of EGFR and
Regulation (anomalous) of Gene_expression (expression) of EGFR
11) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.58 Pain Relevance 0
each member of the EGFR gene family has a multifunction structural organization
Regulation (member) of Gene_expression (family) of EGFR gene
12) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.39 Pain Relevance 0
anti-EGFR therapy has moderate clinical efficacy not only on EGFR-expressing
Regulation (efficacy) of Gene_expression (therapy) of EGFR-expressing
13) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.52 Pain Relevance 0
anti-EGFR therapy has moderate clinical efficacy not only on EGFR-expressing
Regulation (efficacy) of Gene_expression (therapy) of EGFR
14) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.47 Pain Relevance 0
Tumor targets for anti-EGFR therapy include early and advanced stage, and
Regulation (targets) of Gene_expression (therapy) of EGFR associated with cancer
15) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.60 Pain Relevance 0
All patients were required to have EGFR expression of 2+ or 3+ in ?
Regulation (have) of Gene_expression (expression) of EGFR
16) Confidence 0.44 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.82 Pain Relevance 0.03
If these pathways are dysregulated, such as in the case of EGFR overexpression, alterations in cellular growth, survival, angiogenesis and metastases may occur.11–18
Regulation (alterations) of Gene_expression (overexpression) of EGFR associated with metastasis
17) Confidence 0.44 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.66 Pain Relevance 0
Patients were required to have measurable metastatic CRC, no prior treatment for advanced disease, and EGFR expression in ?
Neg (no) Regulation (have) of Gene_expression (expression) of EGFR associated with colon cancer and disease
18) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721355 Disease Relevance 0.83 Pain Relevance 0.07
In one trial, the percentage of tumor cells positive for EGFR expression had to be negative (<1%) or low (1%–9%) and in the other trial, high (?
Regulation (positive) of Gene_expression (expression) of EGFR associated with cancer
19) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721355 Disease Relevance 0.50 Pain Relevance 0.04
Baseline EGFR/ECD levels did not affect PFS in either the combination (p = 0.88) or monotherapy arms (p = 0.32).
Neg (not) Regulation (affect) of Gene_expression (levels) of EGFR in arms
20) Confidence 0.43 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727787 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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