INT111603

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.17
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDH1) cell adhesion (CDH1) Golgi apparatus (CDH1)
plasma membrane (CDH1) cytoplasm (CDH1)
Anatomy Link Frequency
plasma 2
nucleus 2
endometrium 2
mesenchymal cells 2
CDH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 8 98.60 Very High Very High Very High
Dismenorea 6 97.60 Very High Very High Very High
Inflammation 106 94.44 High High
ischemia 12 91.20 High High
fibrosis 1 82.80 Quite High
cINOD 14 68.28 Quite High
palliative 2 67.96 Quite High
metalloproteinase 14 60.80 Quite High
chemokine 11 47.28 Quite Low
cytokine 24 44.08 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 44 99.82 Very High Very High Very High
Acute Renal Failure 84 99.62 Very High Very High Very High
Burns 74 99.40 Very High Very High Very High
Inflammatory Breast Neoplasms 268 99.14 Very High Very High Very High
Malignant Neoplastic Disease 5 98.88 Very High Very High Very High
Interstitial Cystitis 8 98.60 Very High Very High Very High
Dysmenorrhea 6 97.60 Very High Very High Very High
Cancer 363 96.96 Very High Very High Very High
INFLAMMATION 99 94.44 High High
Apoptosis 93 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of cells were positive for E-cadherin and ZO-1, whereas staining for ?
Positive_regulation (for) of Gene_expression (positive) of E-cadherin
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.23 Pain Relevance 0.11
Five variables were significantly associated with IBC in multivariate analysis: MIB1, ERBB2 and E-cadherin overexpression, ER negativity, and MUC1 cytoplasmic staining.
Positive_regulation (overexpression) of Gene_expression (overexpression) of E-cadherin associated with inflammatory breast neoplasms
2) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.50 Pain Relevance 0.03
Surprisingly, E-cadherin overexpression and overfunction is present in MARY-X relative to normal non-IBC cell lines and xenografts [36,38].
Positive_regulation (overexpression) of Gene_expression (overexpression) of E-cadherin associated with inflammatory breast neoplasms
3) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 0.89 Pain Relevance 0.08
The current working model supposes that Snail1 is required for triggering E-cadherin down-regulation and EMT but not for silencing E-cadherin gene expression in mesenchymal cells [3].
Positive_regulation (silencing) of Gene_expression (expression) of E-cadherin in mesenchymal cells
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.61 Pain Relevance 0.04
Loss or reduction of the E-cadherin and beta-catenin expressions and overexpression of CD44s in the round cells are suggested to be contributed to the high propensity for lymphatic permeation and poor prognosis.
Positive_regulation (overexpression) of Gene_expression (expressions) of E-cadherin
5) Confidence 0.33 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 17033799 Disease Relevance 0.78 Pain Relevance 0.07
There was increased expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium in adenomyosis.
Positive_regulation (increased) of Gene_expression (expression) of E-cadherin in endometrium associated with dismenorea
6) Confidence 0.32 Published 2008 Journal Arkh. Patol. Section Abstract Doc Link 19137776 Disease Relevance 0.61 Pain Relevance 0.49
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Positive_regulation (increased) of Gene_expression (expression) of E-cadherin associated with interstitial cystitis
7) Confidence 0.26 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.59 Pain Relevance 0.59
Burns septic ARF group plasma also induced a decreased expression of E-cadherin and pan-cytokeratin epithelial markers (data not shown) and of the tight junction protein ZO-1 (Figure 5G–I).


Positive_regulation (induced) of Gene_expression (expression) of E-cadherin in plasma associated with acute renal failure and burns
8) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.93 Pain Relevance 0.03
At a concentration of 4 x 10(-4) M indomethacin there was increased expression of APC gene (10.9-fold induction; DeltaDeltaCt = 3.43) and E-cadherin gene (3.5-fold induction; DeltaDeltaCt = 1.79).
Positive_regulation (increased) of Gene_expression (expression) of E-cadherin gene
9) Confidence 0.09 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.63 Pain Relevance 0.06
These results suggest the antiproliferative effect of indomethacin may contribute to enhanced cell adhesion through increased expression of E-cadherin and translocation of beta-catenin from the nucleus to the cell membrane.
Positive_regulation (increased) of Gene_expression (expression) of E-cadherin in nucleus associated with adhesions
10) Confidence 0.09 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.48 Pain Relevance 0
The treatment of cells with 4 x 10(-4) M indomethacin caused strong inhibition of cell growth (about 70%), enhanced expression of APC, decreased expression of beta-catenin and induced expression of E-cadherin proteins.
Positive_regulation (induced) of Gene_expression (expression) of E-cadherin
11) Confidence 0.09 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.75 Pain Relevance 0.19
However, group 3 was distinguishable from group 6 based upon strong MUC1 and weak E-cadherin expression in group 3 and weak MUC1 and strong E-cadherin expression in group 6.
Positive_regulation (strong) of Gene_expression (expression) of E-cadherin
12) Confidence 0.08 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 0.85 Pain Relevance 0
These clones showed also a reduced invasiveness and increased E-cadherin expression than the parental cells (Figure 5, panels G–I).
Positive_regulation (increased) of Gene_expression (expression) of E-cadherin
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.79 Pain Relevance 0
In this study, genistein caused a reversion of this EMT phenotype by increasing levels of E-cadherin, a membrane protein that is associated with increased cell–cell adhesion and reduced invasive potential.
Positive_regulation (increasing) of Gene_expression (levels) of E-cadherin associated with adhesions
14) Confidence 0.05 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.54 Pain Relevance 0.03

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