INT111605

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.95
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDH1) cell adhesion (CDH1) Golgi apparatus (CDH1)
plasma membrane (CDH1) cytoplasm (CDH1)
Anatomy Link Frequency
Caco-2 1
bladder 1
mesenchymal cells 1
CDH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 33 97.16 Very High Very High Very High
interstitial cystitis 10 93.28 High High
ischemia 12 91.20 High High
fibrosis 1 76.96 Quite High
cINOD 22 71.88 Quite High
metalloproteinase 20 60.80 Quite High
chemokine 11 47.28 Quite Low
cytokine 12 44.08 Quite Low
antagonist 17 39.08 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Endometroid Carcinoma 34 97.64 Very High Very High Very High
Adhesions 56 97.40 Very High Very High Very High
Cancer 452 95.56 Very High Very High Very High
Hyperplasia 31 93.84 High High
Interstitial Cystitis 10 93.28 High High
Cv Unclassified Under Development 12 91.20 High High
Infection 5 88.64 High High
Endometrial Cancer 220 88.08 High High
Microsatellite Instability 62 86.96 High High
Carcinoma 79 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylation-specific polymerase chain reaction (PCR), i.e., MSP, was performed for CDH1 gene promoter.
Positive_regulation (performed) of CDH1 gene
1) Confidence 0.50 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19184424 Disease Relevance 0.80 Pain Relevance 0.46
The current working model supposes that Snail1 is required for triggering E-cadherin down-regulation and EMT but not for silencing E-cadherin gene expression in mesenchymal cells [3].
Positive_regulation (triggering) of E-cadherin in mesenchymal cells
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.71 Pain Relevance 0.04
The majority of cells were positive for E-cadherin and ZO-1, whereas staining for ?
Positive_regulation (positive) of E-cadherin
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.23 Pain Relevance 0.11
The inactivation of E-cadherin gene by methylation seems to play a role during progression of endometrioid carcinoma, since it is most frequently found in grade 3 and least frequently in grade 1 tumors [10].
Positive_regulation (inactivation) of E-cadherin gene associated with endometroid carcinoma and cancer
4) Confidence 0.44 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.61 Pain Relevance 0
While not identified by global transcript analysis, RT-PCR investigation revealed increased levels of E-cadherin in both Caco-2 (24 hrs) and NHEK (24 and 48 hrs), this in agreement with the previously reported immunohistochemical data [1] that showed increased staining of E-cadherin in NAC treated cells.
Positive_regulation (increased) of E-cadherin in Caco-2
5) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.47 Pain Relevance 0
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Positive_regulation (confirmed) of E-cadherin associated with interstitial cystitis
6) Confidence 0.26 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.46 Pain Relevance 0.46
Elevated E-cadherin may represent an adaptation to increased bladder permeability.


Positive_regulation (Elevated) of E-cadherin in bladder
7) Confidence 0.15 Published 2004 Journal J. Urol. Section Body Doc Link 15017219 Disease Relevance 0 Pain Relevance 0
-catenin pathway may be essential for both the establishment and maintenance of phenotypic characteristics of MMMTs, playing key roles in the regulation of E-cadherin through transactivation of the Slug E-cadherin repressor gene [65].
Positive_regulation (transactivation) of E-cadherin
8) Confidence 0.13 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.40 Pain Relevance 0
In this study, genistein caused a reversion of this EMT phenotype by increasing levels of E-cadherin, a membrane protein that is associated with increased cell–cell adhesion and reduced invasive potential.
Positive_regulation (increasing) of E-cadherin associated with adhesions
9) Confidence 0.08 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.54 Pain Relevance 0.03
At a concentration of 4 x 10(-4) M indomethacin there was increased expression of APC gene (10.9-fold induction; DeltaDeltaCt = 3.43) and E-cadherin gene (3.5-fold induction; DeltaDeltaCt = 1.79).
Positive_regulation (induction) of E-cadherin gene
10) Confidence 0.06 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.62 Pain Relevance 0.05
MiR-200a targets the mRNA of the E-cadherin repressor proteins ZEB1(also known as Tcf8) and ZEB2 (also known as SIP1), subsequently increases the total E-cadherin available for binding to ?
Positive_regulation (increases) of E-cadherin
11) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.29 Pain Relevance 0
MiR-200a targets the mRNA of the E-cadherin repressor proteins ZEB1(also known as Tcf8) and ZEB2 (also known as SIP1), subsequently increases the total E-cadherin available for binding to ?
Positive_regulation (available) of E-cadherin
12) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.29 Pain Relevance 0
This is in agreement with data shown by Ohira et al who have shown induction of the Wnt signaling pathway target gene, E-cadherin, by HDAC inhibition with TSA or GSK3?
Positive_regulation (induction) of E-cadherin
13) Confidence 0.04 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.56 Pain Relevance 0

General Comments

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