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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.47

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cytosol (CTNNA1) aging (CTNNA1) cell adhesion (CTNNA1)
structural molecule activity (CTNNA1) plasma membrane (CTNNA1) cytoplasm (CTNNA1)
CTNNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 8 93.28 High High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 8 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Positive_regulation (confirmed) of alpha-catenin associated with interstitial cystitis
1) Confidence 0.12 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.47 Pain Relevance 0.47

General Comments

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