INT111607

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 103
Total Number 106
Disease Relevance 90.45
Pain Relevance 7.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDH1) cell adhesion (CDH1) Golgi apparatus (CDH1)
plasma membrane (CDH1) cytoplasm (CDH1)
Anatomy Link Frequency
epithelial cells 5
neural 3
plasma 2
brain 2
endometrium 2
CDH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 118 99.54 Very High Very High Very High
COX2 26 99.48 Very High Very High Very High
Dismenorea 19 99.16 Very High Very High Very High
cINOD 55 98.80 Very High Very High Very High
interstitial cystitis 26 98.40 Very High Very High Very High
Inflammation 556 98.16 Very High Very High Very High
Pain 48 98.08 Very High Very High Very High
dorsal root ganglion 5 96.76 Very High Very High Very High
COX-2 inhibitor 26 95.20 Very High Very High Very High
aspirin 27 94.96 High High
Disease Link Frequency Relevance Heat
Cancer 3863 100.00 Very High Very High Very High
Adhesions 263 100.00 Very High Very High Very High
Repression 35 100.00 Very High Very High Very High
Aids-related Complex 8 100.00 Very High Very High Very High
Carcinoma 573 99.98 Very High Very High Very High
Adenocarcinoma 311 99.86 Very High Very High Very High
Skin Cancer 319 99.84 Very High Very High Very High
Coronary Artery Disease 6 99.84 Very High Very High Very High
Breast Cancer 615 99.76 Very High Very High Very High
Targeted Disruption 33 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Gene_expression (expression) of E-cadherin associated with metalloproteinase
1) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.90 Pain Relevance 0.09
These changes are accompanied by a re-localization of the expression patterns of E-cadherin and catenins.
Gene_expression (expression) of E-cadherin
2) Confidence 0.68 Published 2010 Journal J Ethnopharmacol Section Abstract Doc Link 19897022 Disease Relevance 0.93 Pain Relevance 0.10
Decreased expression of E-cadherin is frequent in endometrial carcinoma and may be caused by LOH or promotor hypermethylation.
Gene_expression (expression) of E-cadherin associated with endometrial cancer
3) Confidence 0.68 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.44 Pain Relevance 0
In endometrial carcinoma, partial or complete loss of E-cadherin expression correlates with aggressive behavior [9].
Gene_expression (expression) of E-cadherin associated with aggression and endometrial cancer
4) Confidence 0.68 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.82 Pain Relevance 0
A hallmark of epithelial-mesenchymal transition is loss of E-cadherin expression.
Gene_expression (expression) of E-cadherin
5) Confidence 0.68 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.55 Pain Relevance 0
In all 217 subjects, CDH1 methylation was detected for 69 subjects (31.7%).
Gene_expression (methylation) of CDH1
6) Confidence 0.67 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19184424 Disease Relevance 0.78 Pain Relevance 0.45
To our knowledge, this is the first report of secretory carcinoma in which the e-cadherin expression has been investigated.
Gene_expression (expression) of e-cadherin associated with carcinoma
7) Confidence 0.66 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1764883 Disease Relevance 0.91 Pain Relevance 0
In this report the hypothesis that secretory carcinoma might be considered a variant of ductal carcinoma has been stressed, based on e-cadherin expression, suggesting that it might originate from the ductal component of the mammary gland.
Gene_expression (expression) of e-cadherin in mammary gland associated with ductal carcinoma and carcinoma
8) Confidence 0.66 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1764883 Disease Relevance 0.88 Pain Relevance 0
The majority of cells were positive for E-cadherin and ZO-1, whereas staining for ?
Gene_expression (positive) of E-cadherin
9) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.23 Pain Relevance 0.11
This was true for both arc 1 (D1 and C1) whiskers, and arc 2 (D2 and C2) whiskers.
Gene_expression (whiskers) of arc 1 in whiskers associated with aids-related complex
10) Confidence 0.65 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.33 Pain Relevance 0
A number of specific transcription factors, including Snail, Slug, SIP-1, and Twist, contribute to induction of epithelial mesenchymal transition, acting as transcriptional repressors of the E-cadherin gene.
Gene_expression (repressors) of E-cadherin gene
11) Confidence 0.59 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.60 Pain Relevance 0
The current working model supposes that Snail1 is required for triggering E-cadherin down-regulation and EMT but not for silencing E-cadherin gene expression in mesenchymal cells [3].
Gene_expression (expression) of E-cadherin in mesenchymal cells
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.60 Pain Relevance 0.04
The main hallmark of this process is the loss of E-cadherin expression mainly caused by repressed transcription of this gene (CDH1) [2].
Gene_expression (expression) of E-cadherin
13) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.83 Pain Relevance 0
Loss or reduction of the E-cadherin and beta-catenin expressions and overexpression of CD44s in the round cells are suggested to be contributed to the high propensity for lymphatic permeation and poor prognosis.
Gene_expression (expressions) of E-cadherin
14) Confidence 0.52 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 17033799 Disease Relevance 0.78 Pain Relevance 0.07
Previous studies reported that e-cadherin is present in infiltranting ductal carcinoma and its loss has been reported in most of infiltranting lobular carcinoma [16,17].
Gene_expression (present) of e-cadherin associated with ductal carcinoma and lobular carcinoma
15) Confidence 0.52 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1764883 Disease Relevance 1.07 Pain Relevance 0
To our knowledge, this is the first case of secretory carcinoma involving biopsy of the sentinel lymph node and investigation of the e-cadherin expression.
Gene_expression (expression) of e-cadherin in lymph node associated with carcinoma
16) Confidence 0.52 Published 2006 Journal World J Surg Oncol Section Abstract Doc Link PMC1764883 Disease Relevance 1.08 Pain Relevance 0
It is possible that this different association of Snail1 with clinicopathologic parameters is due to the cell-specific expression of other proteins necessary for the repression by this factor of key targets in epithelial cells, such as E-cadherin.
Gene_expression (expression) of E-cadherin in epithelial cells associated with repression
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 1.01 Pain Relevance 0
Surprisingly, E-cadherin overexpression and overfunction is present in MARY-X relative to normal non-IBC cell lines and xenografts [36,38].
Gene_expression (overexpression) of E-cadherin associated with inflammatory breast neoplasms
18) Confidence 0.45 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 0.89 Pain Relevance 0.08
Finally, IBC and non-IBC showed similar expression levels of the genes WISP3/LIBC, RhoC and E-cadherin, a finding that conflicts with several other reports [31].
Gene_expression (expression) of E-cadherin associated with inflammatory breast neoplasms
19) Confidence 0.45 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.10 Pain Relevance 0.07
Five variables were significantly associated with IBC in multivariate analysis: MIB1, ERBB2 and E-cadherin overexpression, ER negativity, and MUC1 cytoplasmic staining.
Gene_expression (overexpression) of E-cadherin associated with inflammatory breast neoplasms
20) Confidence 0.45 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.50 Pain Relevance 0.03

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