INT111609

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.20
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CTNNA1) aging (CTNNA1) cell adhesion (CTNNA1)
structural molecule activity (CTNNA1) plasma membrane (CTNNA1) cytoplasm (CTNNA1)
Anatomy Link Frequency
neural 1
CTNNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 8 95.62 Very High Very High Very High
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Chondrosarcoma 4 99.56 Very High Very High Very High
Chordoma 131 98.52 Very High Very High Very High
Leukemia 18 98.52 Very High Very High Very High
Myelodysplastic Syndromes 58 95.64 Very High Very High Very High
Interstitial Cystitis 8 95.62 Very High Very High Very High
Myeloid Leukemia 46 95.36 Very High Very High Very High
Acute Promyelocytic Leukemia 1 88.00 High High
Genetic Translocation 1 80.20 Quite High
Cancer 113 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin (CTNNA1) expression by both methylation and histone deacetylation has been shown to contribute to the growth advantage in human MDS or AML with del(5q) [40].
Gene_expression (expression) of CTNNA1 associated with myeloid leukemia and myelodysplastic syndromes
1) Confidence 0.46 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.22 Pain Relevance 0
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Gene_expression (expression) of alpha1-catenin associated with interstitial cystitis
2) Confidence 0.43 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.57 Pain Relevance 0.57
The expression of cell adhesion molecules (CAMs) including E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and neural cell adhesion molecule (NCAM) has been associated with formation and maintenance of chordoma tissue architecture and found of diagnostic value for discriminating chordoma from chondrosarcoma, along with the cytokeratins [89,90].
Gene_expression (expression) of alpha-catenin in neural associated with chondrosarcoma, chordoma and adhesions
3) Confidence 0.03 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox