INT11161

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 10
Speculated 5
Reported most in Abstract
Documents 121
Total Number 126
Disease Relevance 75.33
Pain Relevance 20.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
blood 12
T-cell 10
monocytes 9
B cells 7
lymphocytes 6
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 459 100.00 Very High Very High Very High
Pain 63 99.90 Very High Very High Very High
rheumatoid arthritis 252 99.84 Very High Very High Very High
Angina 61 99.52 Very High Very High Very High
neuralgia 3 99.30 Very High Very High Very High
headache 41 99.28 Very High Very High Very High
Inflammatory mediators 13 99.04 Very High Very High Very High
Migraine 77 99.00 Very High Very High Very High
endometriosis 5 99.00 Very High Very High Very High
Inflammation 612 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Demyelinating Disease 477 100.00 Very High Very High Very High
Dengue Hemorrhagic Fever 417 100.00 Very High Very High Very High
Apoptosis 93 100.00 Very High Very High Very High
Malignant Neoplastic Disease 25 99.96 Very High Very High Very High
Syndrome 87 99.92 Very High Very High Very High
Pain 43 99.90 Very High Very High Very High
Uveitis 13 99.90 Very High Very High Very High
Rheumatoid Arthritis 258 99.84 Very High Very High Very High
Sarcoma 5 99.80 Very High Very High Very High
Congenital Anomalies 17 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA-DR expression, defined both as the proportion of monocytes that were HLA-DR-positive and as monocyte HLA-DR fluorescence intensity, was determined at admission, using whole-blood flow cytometry.
Spec (determined) Gene_expression (expression) of HLA-DR in blood
1) Confidence 0.78 Published 2003 Journal Clin. Sci. Section Abstract Doc Link 12780344 Disease Relevance 0.78 Pain Relevance 0.09
In conclusion, monocyte HLA-DR expression predicts the development of organ dysfunction that occurs early in patients with acute pancreatitis.
Gene_expression (expression) of HLA-DR in monocyte associated with pancreatitis
2) Confidence 0.78 Published 2003 Journal Clin. Sci. Section Abstract Doc Link 12780344 Disease Relevance 0.63 Pain Relevance 0.06
In this paper, additional original data are presented concerning the expression of HLA-DR, DP, and DQ antigens on macrophage-like and fibroblast-like cells within the cartilage-pannus junction in RA.
Gene_expression (expression) of HLA-DR in macrophage associated with rheumatoid arthritis
3) Confidence 0.77 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3042072 Disease Relevance 0.89 Pain Relevance 0.41
It was found that RF associated allele (DRB1* 0405) was present in of 80% of DRB1*04 positive patients.
Gene_expression (present) of DRB1
4) Confidence 0.77 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0.23 Pain Relevance 0
In contrast Berglin et al reported that patients with early RA, had significant association between anti-CCP antibodies and expression of DRB1*0401/0101 [5].
Gene_expression (expression) of DRB1 associated with rheumatoid arthritis
5) Confidence 0.77 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0.56 Pain Relevance 0.20
Twelve cases (63.2%) with anterior uveitis had expressed HLA-DR8 (DRB1 0803).
Gene_expression (expressed) of HLA-DR8 in anterior associated with uveitis
6) Confidence 0.77 Published 1996 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 8644541 Disease Relevance 0.61 Pain Relevance 0.33
A lymphocyte associated antigen, HLA-DR which has been regarded as a B lymphocyte marker was detected in the tumour cells.
Gene_expression (detected) of HLA-DR in B lymphocyte associated with cancer
7) Confidence 0.75 Published 1985 Journal Virchows Arch A Pathol Anat Histopathol Section Abstract Doc Link 3927581 Disease Relevance 0.37 Pain Relevance 0.09
The levels of serum total immunoglobulins and IgG subclasses and the frequencies of the immune response genes at the IGH@, HLA-A, -B, -DRB1, C4A, and C4B loci were analyzed in the patients and in control subjects.
Spec (analyzed) Gene_expression (analyzed) of DRB1
8) Confidence 0.75 Published 2008 Journal J Pain Section Abstract Doc Link 18417422 Disease Relevance 1.61 Pain Relevance 0.58
Determination of HLA-DRB1 allele
Gene_expression (allele) of HLA-DRB1
9) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 1.00 Pain Relevance 0.07
Sequencing of HLA-DRB1 alleles
Gene_expression (alleles) of HLA-DRB1
10) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0 Pain Relevance 0
HLA typing was performed using sequence specific oligonucleotide technique, reversed dot blot hybridization technique (Dynal RELI HLA-DRB1, product No.802.01) [9].
Gene_expression (product) of HLA-DRB1
11) Confidence 0.67 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0 Pain Relevance 0
It is plausible that a lack of vitamin D in utero or early childhood can affect the expression of HLA-DRB1 in the thymus, and impacting on central deletion.
Gene_expression (expression) of DRB1 in thymus
12) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.32 Pain Relevance 0.08
Given the results of this study, variable expression of HLA-DRB1 could affect central deletion of autoreactive T cells.
Gene_expression (expression) of DRB1 in T cells
13) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.29 Pain Relevance 0.08
B cells transiently transfected with the HLA-DRB1*15 gene promoter showed increased expression on stimulation with 1,25-dihydroxyvitamin D3 (P?
Gene_expression (transfected) of HLA-DRB1*15 in B cells
14) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2627899 Disease Relevance 0.48 Pain Relevance 0.14
The putative VDRE was present on all HLA-DRB1*15 bearing haplotypes with no variants found which disrupted the VDRE consensus sequence.
Gene_expression (present) of HLA-DRB1*15
15) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.39 Pain Relevance 0.20
Presence of the multiple sclerosis-associated DRB1*1501 gene was not associated with preferential synthesis of high-affinity antibodies reactive with a single myelin basic protein peptide or with preferential synthesis of either anti-myelin basic protein or anti-proteolipid protein antibodies.
Gene_expression (Presence) of DRB1 associated with multiple sclerosis
16) Confidence 0.65 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 8526468 Disease Relevance 0.80 Pain Relevance 0.77
There was no apparent effect on HLA-DR expression by CD20+ cells.
Gene_expression (expression) of HLA-DR
17) Confidence 0.64 Published 1996 Journal Blood Section Abstract Doc Link 8555493 Disease Relevance 0.55 Pain Relevance 0.16
1 domain of DRB1, DQB1, and DPB1 gene products.
Gene_expression (products) of DRB1
18) Confidence 0.63 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Gene_expression (expression) of HLA-DR in T-cells associated with intrathecal
19) Confidence 0.62 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.62 Pain Relevance 0.61
Effects on expression of HLA-DR by CD14+ cells were variable.
Gene_expression (expression) of HLA-DR
20) Confidence 0.56 Published 1996 Journal Blood Section Abstract Doc Link 8555493 Disease Relevance 0.58 Pain Relevance 0.17

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