INT111632

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Arrb2, Rbm39) transport (Arrb2) intracellular (Arrb2)
cytoplasm (Arrb2) signal transduction (Arrb2) RNA binding (Rbm39)
Anatomy Link Frequency
spinal cord 2
Arrb2 (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 100.00 Very High Very High Very High
agonist 5 98.24 Very High Very High Very High
Spinal cord 2 98.00 Very High Very High Very High
Kappa opioid receptor 2 97.92 Very High Very High Very High
opioid receptor 4 95.48 Very High Very High Very High
Enkephalin 1 92.44 High High
antinociception 2 88.52 High High
intrathecal 1 85.24 High High
tail-flick 1 81.84 Quite High
Analgesic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present result suggests that beta-arrestin-2 may tonically down-regulate a selected population of mu-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord.
beta-arrestin-2 Negative_regulation (down-regulate) of Regulation (population) of receptors in spinal cord associated with mu opioid receptor and spinal cord
1) Confidence 0.03 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12850536 Disease Relevance 0 Pain Relevance 0.96

General Comments

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