INT111668

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.84
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
spinal cord 1
C3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 6 100.00 Very High Very High Very High
Spinal cord 228 99.36 Very High Very High Very High
Bioavailability 1 98.20 Very High Very High Very High
imagery 12 78.56 Quite High
Morphine 2 67.20 Quite High
Kinase C 16 50.88 Quite High
cytokine 16 40.72 Quite Low
Central nervous system 116 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Meningitis 86 99.88 Very High Very High Very High
Spinal Cord Injury 280 99.72 Very High Very High Very High
Cirrhosis 194 99.28 Very High Very High Very High
Infection 38 84.84 Quite High
Injury 228 84.44 Quite High
Sprains And Strains 62 68.88 Quite High
Cancer 8 57.88 Quite High
Lower Respiratory Tract Infection 4 48.56 Quite Low
Lifespan 4 47.68 Quite Low
General Immunology 2 16.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Esters synthesized link dopamine and L-dopa, by a succinyl linker, to C-3 position of glucose (I and II) and to C-6 of galactose (II and IV).
C-3 Binding (link) of associated with dopamine
1) Confidence 0.36 Published 2003 Journal J Drug Target Section Abstract Doc Link 12852438 Disease Relevance 0 Pain Relevance 0.30
Histograms of count (number of events) vs. fluorescence at 530 nm were used to quantify C3 binding to the surface of the pneumococci.


C3 Binding (binding) of associated with bacterial meningitis
2) Confidence 0.31 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 0.59 Pain Relevance 0
Additionally, we have characterized for the first time the localization/association of complement with the infiltrating PMNs in the injured spinal cord, demonstrating that the percentage of infiltrating PMNs that was associated with C1q or C3 in the injured spinal cord is twice as much as that detected in culture.
C3 Binding (associated) of in spinal cord associated with spinal cord injury and spinal cord
3) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.62 Pain Relevance 0.14
The mean percentage of pneumococci with bound C3 was lower in the cirrhotic rats than in controls (Figure 4A), but the difference was not statistically significant (p = 0.075).
C3 Binding (bound) of associated with cirrhosis and bacterial meningitis
4) Confidence 0.23 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.41 Pain Relevance 0
Therefore, while other cells besides PMNs were associated with C1q or C3 in the cord 3 days post-SCI, the infiltrating PMNs represented a significant fraction of this labeling.
C3 Binding (associated) of associated with spinal cord injury
5) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.57 Pain Relevance 0.27
In all, quantitative data of infiltrating PMNs associating with C1q and C3 after SCI support the demonstrated expression of early complement mRNAs and proteins by cultured peritoneal PMNs.
C3 Binding (associating) of associated with spinal cord injury
6) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.46 Pain Relevance 0.14
Immunofluorescence of rat peritoneal PMNs using fluorescent antibodies for PMNs and C1q, C3, or C5b-9/MAC demonstrated that some, but not all cultured PMNs were associated with C1q and C3 proteins; however, as expected from the rt-PCR data above, cultured PMNs were negative for C5b-9/MAC immunofluorescent labeling (Figure 4).
C3 Binding (associated) of
7) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.19 Pain Relevance 0.03

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