INT111672

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.55
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Kcnq2) transmembrane transport (Kcnq2)
Anatomy Link Frequency
neurons 2
Kcnq2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 3 99.96 Very High Very High Very High
Migraine 2 96.40 Very High Very High Very High
Nerve growth factor 126 95.72 Very High Very High Very High
Neuronal excitability 18 94.84 High High
Analgesic 1 86.08 High High
Pain 5 77.84 Quite High
depression 1 75.00 Quite High
anticonvulsant 2 46.72 Quite Low
Trk A 2 5.20 Low Low
Action potential 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 6 82.32 Quite High
Pain 3 77.84 Quite High
Depression 2 75.00 Quite High
Headache 2 75.00 Quite High
Ganglion Cysts 44 32.36 Quite Low
Convulsion 4 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener.
Gene_expression (synthesized) of KCNQ2 associated with potassium channel
1) Confidence 0.68 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12852750 Disease Relevance 0.15 Pain Relevance 0.26
In this patch, Po was 0.36 in the control, slightly higher than that classically observed for KCNQ2/Q3 channels in heterologous systems (Li et al., 2005).
Gene_expression (channels) of KCNQ2
2) Confidence 0.51 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0 Pain Relevance 0.17
We show that the transcription factor Sp1 activates expression of both KCNQ2 and KCNQ3, whereas the transcriptional repressor REST (repressor element 1-silencing transcription factor) represses expression of both of these genes.
Gene_expression (expression) of KCNQ2
3) Confidence 0.49 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926649 Disease Relevance 0.08 Pain Relevance 0.26
KCNQ2, Q4 and Q5 (KCNQ2-5) channels co-express with KCNQ3 to form heterotetrameric voltage-gated K(+) (KCNQ2-5/3) channels that underlie the endogenous M-current and regulate neuronal excitability in CNS and PNS neurons.
Gene_expression (express) of KCNQ2 in neurons associated with neuronal excitability
4) Confidence 0.48 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733209 Disease Relevance 0.16 Pain Relevance 0.13
KCNQ2, Q4 and Q5 (KCNQ2-5) channels co-express with KCNQ3 to form heterotetrameric voltage-gated K(+) (KCNQ2-5/3) channels that underlie the endogenous M-current and regulate neuronal excitability in CNS and PNS neurons.
Gene_expression (express) of KCNQ2-5 in neurons associated with neuronal excitability
5) Confidence 0.48 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733209 Disease Relevance 0.16 Pain Relevance 0.13

General Comments

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