INT111675

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.41
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF14) extracellular space (TNFSF14) extracellular region (TNFSF14)
plasma membrane (TNFSF14) cytoplasm (TNFSF14)
Anatomy Link Frequency
Section 2 1
TNFSF14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lamotrigine 56 100.00 Very High Very High Very High
Gabapentin 20 100.00 Very High Very High Very High
anticonvulsant 22 99.80 Very High Very High Very High
agonist 2 87.88 High High
Action potential 2 82.88 Quite High
Glutamate 12 80.80 Quite High
bDMF 32 80.64 Quite High
Calcium channel 7 77.84 Quite High
carbamazepine 25 76.88 Quite High
depression 22 75.28 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 250 99.08 Very High Very High Very High
Recurrence 16 98.12 Very High Very High Very High
Exanthema 1 95.80 Very High Very High Very High
Urological Neuroanatomy 2 94.28 High High
Syndrome 140 92.60 High High
Death 6 89.12 High High
Apoptosis 9 88.88 High High
Myoclonus 4 87.84 High High
Anxiety Disorder 2 86.16 High High
Convulsion 125 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of myosin light chain phosphatase activity can also influence contractions, but the effects are small compared with those modulating myosin light chain kinase.
Regulation (Modulation) of light
1) Confidence 0.26 Published 2003 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 12853086 Disease Relevance 0.06 Pain Relevance 0.15
A systematic review of randomized trials for treatment of the maintenance phase in BD supported evidence that, along with lithium, LTG and VPA, olanzapine is effective in long-term use significantly reducing manic relapses [45].
Regulation (effective) of LTG associated with manic depressive disorder, lamotrigine and recurrence
2) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 1.53 Pain Relevance 0.66
As discussed in Section 2, newer anticonvulsants, such as LTG, TPM and GBP, are effective in the maintenance treatment of BD (LTG) or as add-ons to first line mood stabilizers (TPM, GBP).
Regulation (effective) of LTG in Section 2 associated with manic depressive disorder, lamotrigine, anticonvulsant and gabapentin
3) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.61 Pain Relevance 0.72
Co-medication may have a dramatic effect on the half-life of LTG (and consequently on efficacy and acute adverse events), and on safety issues, particularly the risk of rash, which is as high as 5% to 10% in younger patients.
Regulation (effect) of LTG associated with exanthema and lamotrigine
4) Confidence 0.02 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.20 Pain Relevance 0.31

General Comments

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