INT111676

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MYH14)
Anatomy Link Frequency
smooth muscle 2
bridge 1
uterine 1
ciliary body 1
MYH14 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 92.72 High High
Action potential 3 87.72 High High
depression 11 70.56 Quite High
Dismenorea 3 69.32 Quite High
potassium channel 5 64.80 Quite High
ischemia 25 58.08 Quite High
cva 98 56.64 Quite High
spinal-cord stimulation 19 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 50 98.94 Very High Very High Very High
Acidosis 2 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 15 98.20 Very High Very High Very High
Dilated Cardiomyopathy 1 94.00 High High
Myocardial Infarction 50 92.48 High High
Ocular Hypertension 2 86.52 High High
Apoptosis 2 73.80 Quite High
Depression 11 70.56 Quite High
Dysmenorrhea 3 69.32 Quite High
Colon Cancer 1 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myosin light chain kinase activity and phosphorylation of myosin are essential components in the pathway of uterine contraction, once Ca(2+) has been elevated.
Phosphorylation (phosphorylation) of myosin in uterine
1) Confidence 0.48 Published 2003 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 12853086 Disease Relevance 0.07 Pain Relevance 0.16
The decrease in the energy rate of utilisation as the exercise progresses has been related to a decline in the rate of ATP production as a result of PCr hydrolysis [29], the accumulation of ADP slowing down cross-bridge ATP utilisation [42], phosphorylation of the so-called regulatory light chain of myosin, regulation by intracellular acidosis, accumulation of inorganic phosphate (Pi) or lowered ATP/ADP ratios [43], [44].
Phosphorylation (phosphorylation) of myosin in bridge associated with acidosis
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957441 Disease Relevance 0.16 Pain Relevance 0
Myosin is known to connect with adhesion plaques, and one isolated report has indicated that myosin heavy chains under some conditions can be tyrosine phosphorylated [25], but, we also cannot rule out the possibility of myosin contamination of the mass spectrometry samples given its abundance in smooth muscle.
Phosphorylation (phosphorylated) of myosin in smooth muscle associated with adhesions
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.92 Pain Relevance 0
Other iris/ciliary body signature genes have known roles in myosin phosphorylation (PPP1R12B), sarcolemmal calcium homeostasis (CASQ2), and ATP availability (CKMT2), all of which may contribute to ciliary body/trabecular meshwork contractility.
Phosphorylation (phosphorylation) of myosin in ciliary body
4) Confidence 0.07 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.32 Pain Relevance 0.03
Rho kinase, or “ROCK”, is an important intracellular enzyme which phosphorylates proteins to affect a number of cellular functions, among them phosphorylation of myosin, resulting in smooth muscle contraction and vasoconstriction.
Phosphorylation (phosphorylation) of myosin in smooth muscle associated with increased venous pressure under development
5) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 0.68 Pain Relevance 0.09

General Comments

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