INT111680

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 9.23
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
sensory neurons 3
macrophage 2
neurons 2
skeletal muscles 1
dendritic cells 1
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 203 99.84 Very High Very High Very High
dorsal root ganglion 39 99.84 Very High Very High Very High
adenocard 87 99.74 Very High Very High Very High
agonist 136 99.14 Very High Very High Very High
Hyperalgesia 78 98.36 Very High Very High Very High
antagonist 85 98.26 Very High Very High Very High
Inflammation 195 97.68 Very High Very High Very High
Root ganglion neuron 1 97.48 Very High Very High Very High
imagery 62 97.44 Very High Very High Very High
Analgesic 13 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 108 99.92 Very High Very High Very High
Ganglion Cysts 41 99.84 Very High Very High Very High
Diabetes Mellitus 127 99.08 Very High Very High Very High
Nociception 148 99.00 Very High Very High Very High
Lung Injury 29 98.86 Very High Very High Very High
Hyperalgesia 84 98.36 Very High Very High Very High
Injury 48 97.96 Very High Very High Very High
INFLAMMATION 240 97.68 Very High Very High Very High
Thrombosis 2 93.16 High High
Pneumonia 14 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Gene_expression (expressed) of P2ry2 in monocytes
1) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0.13
Edg5, P2ry2 and 6) that have not previously been reported to have a macrophage-restricted expression pattern (Table 2).
Gene_expression (expression) of P2ry2 in macrophage
2) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
As demonstrated in figure 1b, P2ry6 expression was strikingly restricted to macrophages and two cell types closely related to macrophages (osteoclasts and dendritic cells), whilst a number of other P2Y family receptors were also highly expressed by this lineage (Table 2).
Gene_expression (expressed) of P2Y in dendritic cells
3) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.12 Pain Relevance 0.06
To define the role played by extracellular ATP in the pathogenesis of lung inflammation due to mechanical ventilation, we 1) examined the effects of ATP exogenously instilled in the airways, 2) measured the concentrations of extracellular ATP in broncho-alveolar lavage (BAL) fluid after mechanical ventilation, 3) determined whether a purinergic receptor antagonist can alleviate the lung injury caused by mechanical ventilation, and 4) documented the expression of the P2Y2 and P2Y4 ATP receptors in lung tissue.
Gene_expression (expression) of P2Y2 in lung associated with lung injury, inflammation, antagonist and pneumonia
4) Confidence 0.54 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.68 Pain Relevance 0.47
Apart from these P2Y family members, P2RY12 was also reported to be selectively expressed in microglia in the rat brain [32].
Gene_expression (expressed) of P2Y in microglia
5) Confidence 0.52 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.18
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Gene_expression (Coexpression) of P2Y2
6) Confidence 0.45 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.52
The effect of UTP is mediated by metabotropic P2Y2 receptors
Gene_expression (receptors) of P2Y2
7) Confidence 0.32 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.46 Pain Relevance 0.49
A P2Y2 mechanism is further supported by the fact that suramin (100 ?
Gene_expression (mechanism) of P2Y2
8) Confidence 0.28 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.54 Pain Relevance 0.15
The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y2 and P2X1 receptors in skeletal muscles of diabetic subjects.


Gene_expression (expression) of P2Y2 in skeletal muscles associated with adenocard and diabetes mellitus
9) Confidence 0.27 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797920 Disease Relevance 0.58 Pain Relevance 0.17
The main findings of the present study are that 1) the vasodilatatory response to ATP, UTP, and ADO infusion was lower in patients with type 2 diabetes compared with age-matched control subjects and 2) type 2 diabetes does not affect the distribution or the gene expression of P2Y2 or P2X1 receptors.
Gene_expression (expression) of P2Y2 associated with adenocard and diabetes mellitus
10) Confidence 0.27 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.64 Pain Relevance 0.05
RT-PCR indicated expression of P2X(2)/P2X(3) (confirmed by immunocytochemistry) and of all cloned P2Y receptors.
Gene_expression (expression) of P2Y
11) Confidence 0.24 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18031810 Disease Relevance 0.42 Pain Relevance 0.56
P2Y2 and P2Y4 receptors were profusely expressed in astrocytes but no immunofluorescence was seen in neurons (Fig. 4, A and B).
Gene_expression (expressed) of P2Y2 in neurons
12) Confidence 0.23 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0
However in the hippocampal cultures we did not find P2Y2 or P2Y4 immunostaining either in neuronal soma or the synaptic release sites identified by synaptophysin labeling (Figs. 3 and 4).
Spec (find) Gene_expression (immunostaining) of P2Y2 in soma
13) Confidence 0.22 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.15
Astrocytes in the same cultures showed abundant immunofluorescence for P2Y2 as well as P2Y4 receptors (Figs. 3 and 4).
Gene_expression (immunofluorescence) of P2Y2 in Astrocytes
14) Confidence 0.22 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.13
As demonstrated in figure 1b, P2ry6 expression was strikingly restricted to macrophages and two cell types closely related to macrophages (osteoclasts and dendritic cells), whilst a number of other P2Y family receptors were also highly expressed by this lineage (Table 2).
Gene_expression (expressed) of P2Y in osteoclasts
15) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.12 Pain Relevance 0.06
Four P2Y receptor subtypes (P2Y1, P2Y2, P2Y4 and P2Y6) have been detected in DRG neurones (Gerevich & Illes, 2004), but their role in nociception has only just begun to be investigated (Gerevich & Illes, 2004; Malin et al. 2008).
Gene_expression (detected) of P2Y2 associated with nociception and dorsal root ganglion
16) Confidence 0.13 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.85 Pain Relevance 0.68
Consistent with the expression of P2X and P2Y receptors in the spinal cord, ATP and UTP increased the [Ca2+]i in primary cultured spinal neurons.
Gene_expression (expression) of P2Y in neurons
17) Confidence 0.03 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
cells express a wide range of P2 receptors including P2Y subtypes [14], while stable analogues of ATP and ADP have been shown to increase insulin secretion and decrease glycemia in vivo [15].
Gene_expression (express) of P2Y
18) Confidence 0.02 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.28 Pain Relevance 0.17
Evidence for the expression and function of other P2Y receptors in sensory neurons is limited [2,9].
Gene_expression (expression) of P2Y in sensory neurons
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.19 Pain Relevance 0.31
We report that Gi-coupled P2Y receptors are widely expressed in peripheral sensory neurons.
Gene_expression (expressed) of P2Y in sensory neurons
20) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2865444 Disease Relevance 1.43 Pain Relevance 0.80

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox