INT111681

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.64
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
P19 1
neurons 1
astrocyte 1
platelet 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 24 99.74 Very High Very High Very High
Root ganglion neuron 1 99.70 Very High Very High Very High
Thermal hyperalgesia 4 95.04 Very High Very High Very High
withdrawal 4 92.08 High High
antagonist 39 85.88 High High
agonist 28 85.24 High High
Pain 13 84.92 Quite High
qutenza 3 76.92 Quite High
Kinase C 6 73.84 Quite High
Glutamate 38 71.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 99.54 Very High Very High Very High
Pressure And Volume Under Development 50 99.44 Very High Very High Very High
Body Weight 33 97.88 Very High Very High Very High
Embryonal Carcinoma 14 97.52 Very High Very High Very High
Hyperalgesia 4 95.04 Very High Very High Very High
Neurodegenerative Disease 27 91.96 High High
Impaired Glucose Tolerance 30 91.20 High High
Epilepsy 37 88.08 High High
Death 30 84.96 Quite High
Pain 15 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of P2Y1 deficiency on glycemia was assessed according to the nutritional status of the animals.
Regulation (effect) of P2Y1
1) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.28 Pain Relevance 0.05
To determine whether the P2Y1 receptor is involved in this process, we performed studies in P2Y1 mice.
Spec (whether) Regulation (involved) of P2Y1
2) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.16 Pain Relevance 0
Patch-clamp analyses using mouse dorsal root ganglion neurons indicated the involvement of P2Y2 rather than P2Y1 receptors.
Regulation (involvement) of P2Y1 in neurons associated with ganglion cysts and root ganglion neuron
3) Confidence 0.44 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.52 Pain Relevance 0.53
Figure 3Glucose tolerance and insulin sensitivity of wt and P2Y1-/- mice.
Regulation (sensitivity) of P2Y1 associated with tolerance
4) Confidence 0.23 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.32 Pain Relevance 0.17
However, the gap-junction protein Cx43 has been shown to modulate both astrocytic P2Y1 receptor expression levels [74] and pharmacological function [75].
Regulation (modulate) of P2Y1 receptor
5) Confidence 0.23 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.28 Pain Relevance 0.09
Several studies have suggested roles for P2Y1Rs in the regulation of astrocyte swelling [37], [38], [39], [40].
Regulation (regulation) of P2Y1Rs in astrocyte associated with pressure and volume under development
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.66 Pain Relevance 0
Moreover, the importance of calcium signaling for differentiation of NPC has been studied [67, 68], and direct evidence for the participation of P2Y1 receptor-activated pathways in the early development has been provided by Scemes et al. [69].
Regulation (participation) of P2Y1 receptor
7) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.29 Pain Relevance 0.06
As an example, we have used suramin, PPADS, and reactive blue 2 to study the participation of P2Y1, P2Y2, and P2X2 receptors in neuronal differentiation of P19 EC cells [38].
Regulation (participation) of P2Y1 in P19 associated with embryonal carcinoma
8) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.15 Pain Relevance 0.21
Although ADP-induced optical aggregometry is considered the gold standard in terms of assessing platelet function in patients receiving clopidogrel, it is a difficult test to perform at the bedside therefore its use in tailored therapy is limited.38 Additionally, ADP-induced optical aggregometry is somewhat non-specific as the effects of ADP on the P2Y1 receptor are included in this test but clopidogrel action does not involve this receptor.
Regulation (effects) of P2Y1 receptor in platelet
9) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672464 Disease Relevance 0 Pain Relevance 0

General Comments

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