INT111682

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.26
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
macrophage 1
monocytes 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 2 97.48 Very High Very High Very High
antagonist 8 95.48 Very High Very High Very High
adenocard 7 94.64 High High
agonist 12 93.24 High High
Thermal hyperalgesia 4 93.12 High High
Inflammatory stimuli 8 91.16 High High
Kinase C 1 89.36 High High
Inflammatory response 12 85.64 High High
Pain 4 83.00 Quite High
Neurotransmitter 2 82.64 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 97.16 Very High Very High Very High
Hyperalgesia 4 93.12 High High
INFLAMMATION 42 90.80 High High
Pain 4 83.00 Quite High
Hypersensitivity 2 75.00 Quite High
Mycobacterial Infection 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Transcription (Coexpression) of P2Y1
1) Confidence 0.52 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.52
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Transcription (mRNA) of P2Y1
2) Confidence 0.52 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.51
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Transcription (expressed) of P2ry1 in monocytes
3) Confidence 0.45 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0.16
Several members of the P2RY family had striking expression patterns in macrophages; P2ry6 mRNA was essentially expressed in a macrophage-specific fashion, whilst P2ry1 and P2ry5 mRNA levels were strongly down-regulated by LPS.
Transcription (levels) of P2ry1 in macrophage
4) Confidence 0.45 Published 2008 Journal Immunome Res Section Abstract Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.11
Region-specific differences in responses to ATP corresponded to regional differences in the expression of mRNA transcripts for the P2Y1 receptor.
Transcription (transcripts) of P2Y1 receptor
5) Confidence 0.08 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16566916 Disease Relevance 0 Pain Relevance 0.41

General Comments

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