INT111683

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 7.96
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
sensory neurons 2
neurons 2
P19 1
hepatocytes 1
brain 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 185 100.00 Very High Very High Very High
dorsal root ganglion 13 99.84 Very High Very High Very High
nociceptor 163 99.44 Very High Very High Very High
intrathecal 16 99.30 Very High Very High Very High
cerebral cortex 10 98.36 Very High Very High Very High
Neuropeptide 14 97.52 Very High Very High Very High
Root ganglion neuron 1 97.48 Very High Very High Very High
ischemia 33 97.44 Very High Very High Very High
Inflammation 158 97.04 Very High Very High Very High
adenocard 93 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 99.84 Very High Very High Very High
Nociception 230 99.40 Very High Very High Very High
Obesity 18 99.24 Very High Very High Very High
Thrombosis 17 98.56 Very High Very High Very High
Cv Unclassified Under Development 28 97.44 Very High Very High Very High
INFLAMMATION 181 97.04 Very High Very High Very High
Injury 75 96.36 Very High Very High Very High
Hyperalgesia 123 94.56 High High
Hypoxia 27 93.72 High High
Brain Hemorrhage 24 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of P2Y1, ADP was anti-nociceptive, suggesting an action of P2YGi receptors that is normally occluded by P2Y1.
Neg (absence) Gene_expression (absence) of P2Y1 associated with nociception
1) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.43 Pain Relevance 0.44
These results support the functional expression of P2Y1 in approximately 40% of DRG neurons in vitro.
Gene_expression (expression) of P2Y1 in neurons
2) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.06 Pain Relevance 0.19
The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice

Pancreatic ?

Gene_expression (receptor) of P2Y1
3) Confidence 0.67 Published 2005 Journal Purinergic Signal Section Title Doc Link PMC2096536 Disease Relevance 0.15 Pain Relevance 0
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (expressed) of P2ry1
4) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.09
P2Y1 receptor expression was examined by using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry.
Spec (examined) Gene_expression (expression) of P2Y1 receptor
5) Confidence 0.65 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20103587 Disease Relevance 0.08 Pain Relevance 0.03
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Gene_expression (Coexpression) of P2Y1
6) Confidence 0.65 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.52
The ADP receptor P2Y1 is also expressed in sensory neurons and has been implicated in sensory transduction [7,8].
Gene_expression (expressed) of ADP receptor P2Y1 in sensory neurons
7) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.20 Pain Relevance 0.33
Intriguingly, these authors also demonstrated that intrathecal administration of a non-selective agonist of P2Y1, P2Y12 and P2Y13 (ADP-?
Gene_expression (agonist) of P2Y1 associated with agonist and intrathecal
8) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.34 Pain Relevance 0.49
Gerevich et al [22] reported that P2Y1 mediates inhibition of VDCCs in isolated DRG neurons by ADP through an action of the ??
Gene_expression (through) of P2Y1 in neurons
9) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.33 Pain Relevance 0.55
In the absence of P2Y1, ADP was anti-nociceptive, suggesting an action of P2YGi receptors that is normally occluded by P2Y1.
Gene_expression (occluded) of P2Y1 associated with nociception
10) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.41 Pain Relevance 0.40
One explanation for these data is that these results may be partly related to an abnormality in hypothalamic functions, where the P2Y1 receptor was shown to be expressed [21, 22].
Gene_expression (expressed) of P2Y1
11) Confidence 0.59 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.05 Pain Relevance 0.08
cells express several P2 receptors including P2Y1 and the modulation of insulin secretion by extracellular nucleotides has suggested that these receptors may contribute to the regulation of glucose homeostasis.
Gene_expression (express) of P2Y1
12) Confidence 0.59 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.12 Pain Relevance 0
The first P2Y receptor to be cloned [2], thus named P2Y1, is an ADP receptor expressed in a wide range of tissues which activates PLC?
Gene_expression (expressed) of P2Y1
13) Confidence 0.59 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.30 Pain Relevance 0.15
The P2Y1 receptor is expressed in platelets [3] and together with the P2Y12 receptor plays an important role in the platelet aggregation induced by ADP or other aggregating agents [6–9].
Gene_expression (expressed) of P2Y1 in platelet
14) Confidence 0.59 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.32 Pain Relevance 0.15
In the same way, P2Y1 receptors are expressed in hepatocytes where they have recently been shown to stimulate glycogenolysis through activation of glycogen phosphorylase [37] but there is currently no evidence for the role of P2Y1 receptors in fat metabolism.
Gene_expression (expressed) of P2Y1 in hepatocytes
15) Confidence 0.59 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.55 Pain Relevance 0.05
In this study, we examined the expression and function of P2Y1 and the Gi-coupled receptors P2Y12, P2Y13 and P2Y14 in sensory neurons to determine their contribution to nociception.


Spec (examined) Gene_expression (expression) of P2Y1 in sensory neurons associated with nociception
16) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2865444 Disease Relevance 0.54 Pain Relevance 0.16
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Gene_expression (expressed) of P2ry1 in monocytes
17) Confidence 0.57 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0.16
However, the gap-junction protein Cx43 has been shown to modulate both astrocytic P2Y1 receptor expression levels [74] and pharmacological function [75].
Gene_expression (expression) of P2Y1 receptor
18) Confidence 0.39 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.27 Pain Relevance 0.09
P2Y1 receptors are intensely expressed in Purkinje cells in deep layers of the cerebral cortex and in ischemia-sensitive areas of the hippocampus [165].
Gene_expression (expressed) of P2Y1 in hippocampus associated with ischemia, hippocampus and cerebral cortex
19) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.03 Pain Relevance 0.44
Differential expression and activity of P2Y1, P2Y2, P2Y4, P2X2 subtypes and P2X6 subunits were reported during neuronal maturation of P19 cells [38, 39].
Gene_expression (expression) of P2Y1 in P19
20) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.27 Pain Relevance 0.11

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