INT11173

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.76
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 3
muscle tissue 1
follicle 1
duodenum 1
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 13 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
Morphine 1 99.60 Very High Very High Very High
Somatostatin 3 98.16 Very High Very High Very High
tetrodotoxin 5 97.20 Very High Very High Very High
Serotonin 2 94.16 High High
Cholecystokinin 2 88.72 High High
Central nervous system 2 85.28 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 93.76 High High
Aggression 1 86.08 High High
Vibrio Infection 1 81.60 Quite High
Catalepsy 1 78.80 Quite High
Convulsion 2 76.16 Quite High
Cancer 1 69.00 Quite High
Fever 2 68.24 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 67.76 Quite High
Urological Neuroanatomy 1 59.24 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contractile response to EM-523 or motilin was reduced markedly after treatment of the preparation with a high concentration of either agent, and cross-tachyphylaxis between EM-523 and motilin was also observed.
motilin Binding (cross-tachyphylaxis) of
1) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2395122 Disease Relevance 0 Pain Relevance 0.12
EM574 and porcine motilin specifically displaced [125I-Tyr23]canine motilin bound to gastric antral smooth muscle homogenates with plC50 values of 8.21 +/- 0.13 and 9.20 +/- 0.11, respectively.
motilin Binding (bound) of in smooth muscle
2) Confidence 0.36 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9088872 Disease Relevance 0 Pain Relevance 0.20
EM574 and porcine motilin specifically displaced [125I-Tyr23]canine motilin bound to gastric antral smooth muscle homogenates with plC50 values of 8.21 +/- 0.13 and 9.20 +/- 0.11, respectively.
porcine motilin Binding (bound) of in smooth muscle
3) Confidence 0.36 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9088872 Disease Relevance 0 Pain Relevance 0.20
Erythromycin has been shown to interact with gastrointestinal smooth muscle in a similar manner to motilin, and has been postulated as a motilin receptor agonist.
motilin Binding (interact) of in smooth muscle associated with agonist
4) Confidence 0.31 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1538793 Disease Relevance 0 Pain Relevance 0.13
Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro.
motilin Binding (recognized) of associated with morphine
5) Confidence 0.30 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.22
Similarly, preabsorption with growth hormone, luteinizing hormone, follicle-stimulating hormone, motilin or fetuin did not eliminate immunoreactivity in the brain.
motilin Binding (preabsorption) of in follicle
6) Confidence 0.12 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2716951 Disease Relevance 0.06 Pain Relevance 0.25
The importance of enteric neural influence from the duodenum and the role of motilin in the regulation of pancreatic periodicity and its synchronization with the duodenal motility cycle remain to be determined.
motilin Binding (synchronization) of in duodenum
7) Confidence 0.05 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8789416 Disease Relevance 0 Pain Relevance 0.16
These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing factor and somatostatin.
motilin Binding (receptors) of associated with somatostatin
8) Confidence 0.05 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 12482730 Disease Relevance 0 Pain Relevance 0.05
When DCs are activated after antigen ingestion they may migrate to other zones in the PP or to the MLN.
MLN Binding (migrate) of
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0.22 Pain Relevance 0
The list of peptides includes, but is not limited to: ACTH, angiotensin, bombesin, bradykinin, calcitonin, casomorphin, CCK, ceruletide, CGRP, CRF, dermorphin, DSIP, dynorphin, endorphins, enkephalins, GRF, gastrin, LHRH, litorin, metkephamid, MIF-l, motilin, MSH, NPY, NT, oxytocin, ranatensin, sauvagine, substances P and K, somatostatin, TRH, VIP, vasopressin, and vasotocin.
motilin Binding (limited) of associated with dynorphin, somatostatin, enkephalin and bradykinin
10) Confidence 0.02 Published 1986 Journal Peptides Section Abstract Doc Link 3534808 Disease Relevance 0.31 Pain Relevance 0.49
Mitemcinal as well as other motilin agonists displaced (125)I-pMTL bound to a homogenate of the rabbit duodenum muscle tissue.
motilin Binding (bound) of in muscle tissue associated with agonist
11) Confidence 0.01 Published 2007 Journal Pharmacology Section Abstract Doc Link 17183187 Disease Relevance 0 Pain Relevance 0.36

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