INT111739

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.90
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
hypothalamus 3
arcuate nucleus 1
spike 1
heart 1
hippocampus 1
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 49 100.00 Very High Very High Very High
Hippocampus 14 99.68 Very High Very High Very High
Inflammation 13 99.64 Very High Very High Very High
tetrodotoxin 5 99.60 Very High Very High Very High
qutenza 4 99.10 Very High Very High Very High
antagonist 68 98.76 Very High Very High Very High
opiate 8 98.68 Very High Very High Very High
withdrawal 8 98.52 Very High Very High Very High
agonist 48 98.44 Very High Very High Very High
Peripheral nervous system 2 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colitis 8 99.92 Very High Very High Very High
INFLAMMATION 9 99.64 Very High Very High Very High
Congenital Anomalies 25 99.16 Very High Very High Very High
Heart Defects 3 98.04 Very High Very High Very High
Convulsion 5 97.32 Very High Very High Very High
Craniofacial Abnormalities 2 97.02 Very High Very High Very High
Failure To Thrive 5 95.36 Very High Very High Very High
Aids-related Complex 12 94.64 High High
Hyperphagia 18 92.32 High High
Targeted Disruption 31 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
Negative_regulation (lacking) of NPY gene associated with opiate and withdrawal
1) Confidence 0.43 Published 2006 Journal Synapse Section Abstract Doc Link 16952158 Disease Relevance 0 Pain Relevance 0.64
BIBP3226 increased spontaneous spike frequency, suggesting an ongoing Y1 receptor-mediated NPY inhibition.
Negative_regulation (inhibition) of NPY in spike
2) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470140 Disease Relevance 0.07 Pain Relevance 0.41
In the hypothalamus, the fed state is characterized by increased proopiomelanocortin (POMC) and decreased agouti related protein (AgRP) mRNA and neuropeptide Y (NPY) mRNA contents [15], [16], [17], as observed in our mice (figure 1A).
Negative_regulation (decreased) of NPY in hypothalamus associated with neuropeptide
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.05
Attenuation of acute experimental colitis by preventing NPY Y1 receptor signaling.
Negative_regulation (preventing) of NPY associated with colitis and qutenza
4) Confidence 0.41 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15499082 Disease Relevance 0.89 Pain Relevance 0.41
These data indicate that NPY and Y1 receptor are involved in intestinal inflammation and suggest that inhibition of NPY Y1 receptor signaling may provide a novel therapeutic approach in the treatment of colonic inflammation.
Negative_regulation (inhibition) of NPY associated with inflammation
5) Confidence 0.41 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15499082 Disease Relevance 0.94 Pain Relevance 0.39
Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal.
Negative_regulation (Lack) of neuropeptide Y associated with neuropeptide, opiate and withdrawal
6) Confidence 0.38 Published 2006 Journal Synapse Section Title Doc Link 16952158 Disease Relevance 0 Pain Relevance 0.64
For example, NPY levels were decreased in ileum of PC2 deficient mice, but NPY content was not altered in hypothalamus that is abundant in NPY.
Negative_regulation (decreased) of NPY in hypothalamus
7) Confidence 0.35 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.90
Specifically, in the arcuate nucleus of the hypothalamus, NPY mRNA was increased after 8 hours of maternal deprivation in P8 mouse pups [10].
Negative_regulation (deprivation) of NPY mRNA in hypothalamus
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.99 Pain Relevance 0
Leptin has opposite effects on each pathway with regard to feeding, facilitating transmission in the POMC/CART system and inhibiting the NPY/AgRP neurones, when measure by a system using fluorescent protein (GFP)-tagged POMC (red) and NPY (green) neurones [57].
Negative_regulation (inhibiting) of NPY
9) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0
CART arcuate nucleus neurones markedly inhibit NPY-induced feeding in fasted and normal rats [56].
Negative_regulation (inhibit) of NPY-induced in arcuate nucleus
10) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.03
Similarly to ghrelin, the orexigenic effect of NPY is abolished by rimonabant administration and is totally lost in CB1-KO mice [27].
Negative_regulation (abolished) of NPY
11) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.37
Similarly to ghrelin, the orexigenic effect of NPY is abolished by rimonabant administration and is totally lost in CB1-KO mice [27].
Negative_regulation (lost) of NPY
12) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.38
Through studies in these mice and through in vitro studies in the presence of selective NPY Y1 receptor agonists and antagonists, Howell et al. [35] demonstrated that the neuroproliferative effect of NPY in the hippocampus is mediated through the neuropeptide Y receptor NPY Y1 (NPY1R).
Negative_regulation (effect) of NPY in hippocampus associated with antagonist, neuropeptide, agonist and hippocampus
13) Confidence 0.23 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.37 Pain Relevance 0.36
Importantly, the number of c-Fos/NPY–positive cells, but not POMC cells, was reduced to 10% in response to intragastric glucose.
Negative_regulation (reduced) of NPY
14) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.49 Pain Relevance 0.08
These include skeletal and craniofacial abnormalities (Lpar1, Pitx2, Satb2, Tcof1, Trps1); heart defects (Adm, Cited2, Cxcl12, Gja1, Hey2, Pitx2, Mef2c); reduced body size (Ebf1, Lpar1, Hsd3b7, Mef2c); decreased adiposity (Cebpb, Ebf1, Lpar1, Npy, Vldlr); behavioral abnormalities (Avpr1a, Ctnnd2, Lpar1, Vldlr); seizures (Cdk5r1, Gabrb1, Gabrb2, Neto1, Nr4a3, Plcb1, S100b, Sv2b); and hearing deficits (Cldn11, Eya, Gjb2, Gjb6) [66], [92]–[124].
Negative_regulation (decreased) of Npy in heart associated with convulsion, congenital anomalies, heart defects and craniofacial abnormalities
15) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.60 Pain Relevance 0
First, we analyzed POMC, AgRP and NPY mRNAs levels in these clamped mice (figure 2B) and observed a significant 3 fold increase in POMC mRNA levels and a 2.3 and 1.6 fold decrease respectively in AgRP and NPY mRNA levels in the eGHI mice compared to the control mice (figure 2B).
Negative_regulation (decrease) of NPY mRNA
16) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.12 Pain Relevance 0

General Comments

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