INT111741

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.38
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
colon 2
T cells 2
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 62 100.00 Very High Very High Very High
Somatostatin 19 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 99.92 Very High Very High Very High
Multiple sclerosis 23 99.00 Very High Very High Very High
substance P 59 98.76 Very High Very High Very High
Crohn's disease 25 98.44 Very High Very High Very High
Spinal cord 3 98.14 Very High Very High Very High
qutenza 5 96.32 Very High Very High Very High
Inflammation 141 82.96 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 14 99.10 Very High Very High Very High
Multiple Sclerosis 28 99.00 Very High Very High Very High
Disease 59 98.44 Very High Very High Very High
Inflammatory Bowel Disease 96 98.16 Very High Very High Very High
Colitis 60 97.96 Very High Very High Very High
Asthma 1 96.84 Very High Very High Very High
Hypersensitivity 4 86.80 High High
INFLAMMATION 142 82.96 Quite High
Diarrhoea 4 75.20 Quite High
Pressure Volume 2 Under Development 1 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a series of ALS patients, CSF levels of VIP were found to be significantly lower compared with controls.62 VIP has demonstrated potent effects on neurite outgrowth in spinal cord cultures suggesting its use in treatment of ALS.63 Interestingly Sun and colleagues64 noted impaired VIP receptor (VPAC2) production in activated T cells in MS patients, suggesting transcription irregularity at promoter regions of the VPAC2 gene.
Negative_regulation (impaired) of Gene_expression (production) of VIP in T cells associated with multiple sclerosis, motor neuron diseases and spinal cord
1) Confidence 0.33 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.30 Pain Relevance 0.24
Results demonstrated three features with regard to the selective roles of PC2 in determining the production of NPY, somatostatin-28, enkephalin, VIP, galanin, and CRF in neuroendocrine tissues.
Spec (determining) Negative_regulation (determining) of Gene_expression (production) of VIP associated with somatostatin and enkephalin
2) Confidence 0.32 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.72
CGRP, somatostatin and VIP as generally suppressive neuropeptides
Negative_regulation (suppressive) of Gene_expression (neuropeptides) of VIP associated with neuropeptide, somatostatin and calcitonin gene-related peptide
3) Confidence 0.27 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.27 Pain Relevance 0.85
In contrast, Mazumdar and Das found decreased expression of VIP immunoreactivity in the colon of both CD and UC patients, compared to controls [52], while two other studies showed a significant decreased of rectal and colonic VIP in UC and CD patients.
Negative_regulation (decreased) of Gene_expression (expression) of VIP in colon associated with inflammatory bowel disease and crohn's disease
4) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.81 Pain Relevance 0.45

General Comments

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