INT111758

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.94
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
kinase activity (Insrr) signal transducer activity (Drd2)
Drd2 (Mus musculus)
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 36 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Dynorphin 12 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D1(-/-) mice had normal GABA(A) receptor levels, reduced dynorphin and substance P, and increased enkephalin mRNA and dopamine D2-like binding.
D2 Binding (binding) of ) receptor associated with dopamine, gaba, dynorphin, enkephalin and substance p
1) Confidence 0.01 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.33 Pain Relevance 1.43
D1(-/-)D3(-/-) mice evidenced decreased dynorphin and substance P but normal enkephalin expression, whereas dopamine D2-like and GABA(A) receptor binding were increased.
D2 Binding (binding) of ) receptor associated with gaba, dopamine, dynorphin, enkephalin and substance p
2) Confidence 0.01 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.30 Pain Relevance 1.45
D1(-/-)D3(-/-) mice evidenced decreased dynorphin and substance P but normal enkephalin expression, whereas dopamine D2-like and GABA(A) receptor binding were increased.
D2 Binding (binding) of ) receptor associated with gaba, dopamine, dynorphin, enkephalin and substance p
3) Confidence 0.01 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.30 Pain Relevance 1.45

General Comments

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