INT11177

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Context Info
Confidence 0.81
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 5.74
Pain Relevance 6.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
carbohydrate metabolic process (Ldha) cytoplasm (Ldha)
Anatomy Link Frequency
Plasma 1
macrophages 1
hepatocytes 1
liver 1
neurons 1
Ldha (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 30 99.80 Very High Very High Very High
Paracetamol 44 99.38 Very High Very High Very High
Enkephalin 9 99.08 Very High Very High Very High
Dopamine 12 98.68 Very High Very High Very High
Analgesic 7 95.52 Very High Very High Very High
Potency 5 93.36 High High
tetrodotoxin 1 90.16 High High
Catecholamine 1 88.08 High High
nMDA receptor 2 83.12 Quite High
anesthesia 2 81.44 Quite High
Disease Link Frequency Relevance Heat
Death 30 99.62 Very High Very High Very High
Liver Cancer 1 99.60 Very High Very High Very High
Injury 15 99.56 Very High Very High Very High
Parkinson's Disease 124 98.16 Very High Very High Very High
Apoptosis 31 97.80 Very High Very High Very High
Necrosis 14 90.60 High High
Adenocarcinoma 1 90.48 High High
Reperfusion Injury 30 87.00 High High
Pulmonary Disease 2 84.00 Quite High
Stress 21 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lactate dehydrogenase release was also significantly reduced.
Localization (release) of Lactate dehydrogenase
1) Confidence 0.81 Published 2004 Journal Circulation Section Body Doc Link 14993125 Disease Relevance 0 Pain Relevance 0
FeCl2 led to immediate ethane production followed later on by lactate dehydrogenase release from the liver.
Localization (release) of lactate dehydrogenase in liver
2) Confidence 0.75 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6870910 Disease Relevance 0 Pain Relevance 0.31
Over the next 24-72 h substantial numbers of neurons, but not glia, degenerated, releasing lactate dehydrogenase to the bathing medium.
Localization (releasing) of lactate dehydrogenase in neurons
3) Confidence 0.73 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1978266 Disease Relevance 0.10 Pain Relevance 0.17
Plasma DNA was measured fluorometrically by the dye PicoGreen while lactate dehydrogenase (LDH) and caspase 3, other molecules released with cell injury or death, were measured by enzymatic assays.
Localization (released) of lactate dehydrogenase in Plasma associated with injury and death
4) Confidence 0.52 Published 2008 Journal Biomarkers Section Abstract Doc Link 18270870 Disease Relevance 1.07 Pain Relevance 0.25
Acetaminophen caused DNA damage from 1-4 hr onward and produced significant release of lactate dehydrogenase and [3H]adenine nucleotides at later times.
Localization (release) of lactate dehydrogenase associated with paracetamol
5) Confidence 0.41 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1957310 Disease Relevance 0.43 Pain Relevance 0.50
MENK did not elicit any significant extracellular release of lactate dehydrogenase (LDH) either, indicating that, under the experimental conditions described, the cells remained intact.
Localization (release) of lactate dehydrogenase associated with enkephalin
6) Confidence 0.38 Published 1993 Journal Biomed. Pharmacother. Section Abstract Doc Link 8329664 Disease Relevance 0 Pain Relevance 0.70
Exposure of HepG2 cells to CHP induced time- and dose-dependent cytotoxicity, as judged from lactate dehydrogenase activity (LDH) released into the medium.
Localization (released) of lactate dehydrogenase
7) Confidence 0.37 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928074 Disease Relevance 0.21 Pain Relevance 0.36
Cytotoxicity was assessed by lactate dehydrogenase leakage and release of [3H]adenine from a prelabeled nucleotide pool.
Localization (release) of lactate dehydrogenase
8) Confidence 0.36 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1957310 Disease Relevance 0.49 Pain Relevance 0.49
The rates of protein synthesis decreased within 4 hr after administration of 10 mM APAP and occurred after significant depletion of intracellular glutathione and covalent binding of APAP to proteins, but preceded the leakage of lactate dehydrogenase into the media.
Localization (leakage) of lactate dehydrogenase associated with paracetamol
9) Confidence 0.35 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1539164 Disease Relevance 0 Pain Relevance 0.84
The hydrocarbon evolution was reversible and preceded cell disintegration monitored by release of lactate dehydrogenase. 4) The few human data available indicate that man has a much lower activity of hydroperoxide metabolizing enzymes and much less glutathione.
Localization (release) of lactate dehydrogenase
10) Confidence 0.34 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6678834 Disease Relevance 0.22 Pain Relevance 0.18
MPP+ was also more potent than MPTP in releasing endogenous DA from striatal synaptosomes (EC50 = 3 vs. 30 microM), but did not release the cytoplasmic markers tyrosine hydroxylase and lactate dehydrogenase (LDH).
Neg (not) Localization (release) of lactate dehydrogenase associated with parkinson's disease and dopamine
11) Confidence 0.29 Published 1986 Journal Life Sci. Section Abstract Doc Link 3490612 Disease Relevance 0.61 Pain Relevance 1.03
Exposure of macrophages to 10 and 100 microM ketamine, which correspond to 0.1 and 1 times the clinically relevant concentration, for 1, 6, and 24 h had no effect on cell viability or lactate dehydrogenase release.
Localization (release) of lactate dehydrogenase in macrophages associated with ketamine
12) Confidence 0.29 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.09 Pain Relevance 0.52
When the administered concentration reached 1000 microM, ketamine caused a release of lactate dehydrogenase and cell death.
Localization (release) of lactate dehydrogenase associated with ketamine and death
13) Confidence 0.29 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.10 Pain Relevance 0.56
Hepatotoxic effects of APAP-mediated Ca2+ deregulation were confirmed in both primary mouse hepatocytes and the human hepatoblastoma HepG2 cell line by lactate dehydrogenase (LDH) release and tetrazolium reduction using the 3-4,5-dimethylthiazole-2-yl-2,5-diphenyltetrazolium bromide thiazol blue(MTT) assay.
Localization (release) of lactate dehydrogenase in hepatocytes associated with liver cancer
14) Confidence 0.17 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.56 Pain Relevance 0.15
The cytoprotective effects of neurotropin against hydrogen peroxide and cigarette smoke extracts was demonstrated by an attenuation of lactate dehydrogenase release from oxidant-exposed A549 cells and the inhibition of apoptosis.
Localization (release) of lactate dehydrogenase in A549 associated with apoptosis
15) Confidence 0.15 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17585112 Disease Relevance 0.72 Pain Relevance 0.07
Cell death was measured from lactate dehydrogenase (LDH) release in the cell-free supernatants using a CytoTox 96® Non-Radioactive Cytotoxicity Assay kit (Promega, Madison, WI).


Localization (release) of lactate dehydrogenase associated with death
16) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.15 Pain Relevance 0
Quantification of damage may also be provided by measuring the release of intracellular proteins such as lactate dehydrogenase or troponin I [4].
Localization (release) of lactate dehydrogenase
17) Confidence 0.03 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.98 Pain Relevance 0

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