INT1118

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Context Info
Confidence 0.77
First Reported 1978
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 73
Total Number 74
Disease Relevance 47.24
Pain Relevance 9.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
lymphocytes 5
B-cell 4
Cerebrospinal fluid 2
monocytes 2
bands 2
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 33 99.98 Very High Very High Very High
rheumatoid arthritis 611 99.84 Very High Very High Very High
Central nervous system 34 99.52 Very High Very High Very High
Multiple sclerosis 88 99.44 Very High Very High Very High
abatacept 2 99.24 Very High Very High Very High
imagery 57 98.24 Very High Very High Very High
spinal inflammation 8 98.00 Very High Very High Very High
Arthritis 96 97.00 Very High Very High Very High
Neuropeptide 1 96.96 Very High Very High Very High
Opioid 9 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 17 100.00 Very High Very High Very High
Togavirus Infection 8 100.00 Very High Very High Very High
Hepatitis 5 100.00 Very High Very High Very High
Herpes Simplex Virus 4 100.00 Very High Very High Very High
Cytomegalovirus Infection 1 100.00 Very High Very High Very High
Leukocytosis 11 99.90 Very High Very High Very High
Rheumatoid Arthritis 620 99.84 Very High Very High Very High
Ancylostoma Infection 4 99.80 Very High Very High Very High
Fever 93 99.78 Very High Very High Very High
Infection 399 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cerebrospinal fluid exam showed elevation of protein, mononuclear pleocytosis and immunoglobulin synthesis.
Gene_expression (synthesis) of immunoglobulin in Cerebrospinal fluid associated with leukocytosis
1) Confidence 0.77 Published 2008 Journal J. Neurol. Sci. Section Abstract Doc Link 17949753 Disease Relevance 0.87 Pain Relevance 0.43
The patient also developed a nonspecific increase in immunoglobulin production.
Gene_expression (production) of immunoglobulin
2) Confidence 0.70 Published 1997 Journal Neurology Section Abstract Doc Link 9191777 Disease Relevance 0.90 Pain Relevance 0.08
Some components of the immune response, including phagocytosis, natural killer cell activity and mucosal immunoglobulin A production (especially in children), can be improved by some probiotic bacteria.
Gene_expression (production) of immunoglobulin in natural killer cell
3) Confidence 0.67 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19442167 Disease Relevance 0.38 Pain Relevance 0.13
Following Bruton’s initial description of the beneficial effects of antibody replacement in a patient with severe deficiency in immunoglobulin production, intramuscular dosing became the primary route of administration.
Gene_expression (production) of immunoglobulin
4) Confidence 0.54 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.48 Pain Relevance 0
The first immunoglobulin products introduced for widespread intravenous use were Gamimune® (Cutter Biologicals) and Sandoglobulin® (Sandoz Pharmaceuticals, now Novartis) in the early 1980s.
Gene_expression (products) of immunoglobulin
5) Confidence 0.54 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.38 Pain Relevance 0
Circulating monoclonal immunoglobulin and specific anomalies on nerve biopsy were absent.
Neg (absent) Gene_expression (absent) of immunoglobulin in nerve
6) Confidence 0.52 Published 1984 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 6093216 Disease Relevance 0.85 Pain Relevance 0.11
Analyses of the cerebrospinal fluid and serum did not reveal signs of immunoglobulin synthesis within the central nervous system, i.e. findings encountered in a considerable proportion of patients with optic neuritis.
Gene_expression (synthesis) of immunoglobulin in optic associated with optic neuritis, central nervous system and neuritis
7) Confidence 0.49 Published 1978 Journal J. Neurol. Sci. Section Abstract Doc Link 151734 Disease Relevance 0.70 Pain Relevance 0.15
Subsequent immunoglobulin products have been manufactured using at least two different viral inactivation procedures, and some newer generation products attempt to screen out prions as well.


Gene_expression (products) of immunoglobulin
8) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.63 Pain Relevance 0
Patients with anti-IgA antibodies, intolerant of low-IgA IVIg have successfully been transitioned to subcutaneous therapy.20,29 Young children and pregnant women with PIDD have safely received subcutaneous infusions of immunoglobulin.30,31 And while little data exists on the use of subcutaneous immunoglobulin therapy in patients with significant thrombocytopenia, anticoagulant use or bleeding disorders, there is a report of the safe use of subcutaneous therapy in a child with CVID and von Willebrand disease.32

Comparative costs of immunoglobulin therapy

Gene_expression (therapy) of immunoglobulin associated with coagulation disorder, thrombocytopenia and disease
9) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.55 Pain Relevance 0
Patients with anti-IgA antibodies, intolerant of low-IgA IVIg have successfully been transitioned to subcutaneous therapy.20,29 Young children and pregnant women with PIDD have safely received subcutaneous infusions of immunoglobulin.30,31 And while little data exists on the use of subcutaneous immunoglobulin therapy in patients with significant thrombocytopenia, anticoagulant use or bleeding disorders, there is a report of the safe use of subcutaneous therapy in a child with CVID and von Willebrand disease.32

Comparative costs of immunoglobulin therapy

Gene_expression (therapy) of immunoglobulin associated with coagulation disorder, thrombocytopenia and disease
10) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.68 Pain Relevance 0
However, all cost estimates agree that the immunoglobulin product itself constitutes most of the treatment cost, and that home therapy is preferable to institutional infusion therapy, whether the intravenous or subcutaneous route is used.
Gene_expression (product) of immunoglobulin
11) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.25 Pain Relevance 0
His Mantoux, immunoglobulin M, and immunoglobulin G for tuberculosis tests were all negative.
Neg (negative) Gene_expression (negative) of immunoglobulin associated with mycobacterial infection
12) Confidence 0.27 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2916915 Disease Relevance 0.74 Pain Relevance 0
His Mantoux, immunoglobulin M, and immunoglobulin G for tuberculosis tests were all negative.
Neg (negative) Gene_expression (negative) of immunoglobulin associated with mycobacterial infection
13) Confidence 0.27 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2916915 Disease Relevance 0.74 Pain Relevance 0
Baseline values for serum immunoglobulin levels in the injected and inhaled vaccine groups were equal as shown in Table 2.


Gene_expression (levels) of immunoglobulin
14) Confidence 0.18 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0 Pain Relevance 0
This induced anti-capsular antibody, predominantly IgG, and serum levels of immunoglobulin have been used as a surrogate measure of clinical protection.
Gene_expression (levels) of immunoglobulin
15) Confidence 0.18 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 1.04 Pain Relevance 0
The studies do agree that inhaled 23-PPV is less effective than injected but in our series we did not see the increase in serum immunoglobulin levels in response to inhaled vaccine seen in some subjects (4/10 in healthy subjects, 7/10 in COPD patients) previous studies.
Gene_expression (levels) of immunoglobulin associated with pulmonary disease
16) Confidence 0.15 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.10 Pain Relevance 0
Baseline values for BAL immunoglobulin levels in the injected and inhaled vaccine groups were equal as shown in Table 2.


Gene_expression (levels) of immunoglobulin
17) Confidence 0.15 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0 Pain Relevance 0
Further tests, including immunoglobulin electrophoresis and assay of the serum levels of kappa and lambda light chains, demonstrated that his myeloma was of the IgM, kappa subtype.
Gene_expression (electrophoresis) of immunoglobulin
18) Confidence 0.12 Published 1999 Journal Ann. Hematol. Section Abstract Doc Link 10089027 Disease Relevance 0.10 Pain Relevance 0.08
Monoclonal immunoglobulin was not detected in serum.
Neg (not) Gene_expression (detected) of immunoglobulin
19) Confidence 0.11 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 2067086 Disease Relevance 0.85 Pain Relevance 0.09
Gateways to clinical trials.

(+)-Dapoxetine hydrochloride, (R)-Etodolac; Abatacept, ABT-510, Adalimumab, Agatolimod sodium, Alemtuzumab, Alvocidib hydrochloride, Aminolevulinic acid methyl ester, Aripiprazole, AS01B, AS02B, AS02V, Azacitidine; Becatecarin, Bevacizumab, Bevirimat, Bortezomib, Bremelanotide; CAIV-T, Canfosfamide hydrochloride, CHR-2797, Ciclesonide, Clevidipine; Darbepoetin alfa, Decitabine, Degarelix acetate, Dendritic cell-based vaccine, Denosumab, Desloratadine, DMXB-Anabaseine, Duloxetine hydrochloride, Dutasteride; Ecogramostim, Eicosapentaenoic acid/docosahexaenoic acid, Eletriptan, Enzastaurin hydrochloride, Erlotinib hydrochloride, Escitalopram oxalate, Etoricoxib, Everolimus, Ezetimibe, Ezetimibe/simvastatin; Ferumoxytol, Fesoterodine fumarate, Fulvestrant; Gefitinib, GM-CSF DNA, GSK-690693; H5N1 avian flu vaccine, Hepatitis B hyperimmunoglobulin, Human Fibroblast Growth Factor 1, Hypericin-PVP; Icatibant acetate, Iclaprim, Immunoglobulin intravenous (human), Ipilimumab, ISS-1018; L19-IL-2, Lapuleucel-T, Laropiprant, Liposomal doxorubicin, LP-261, Lumiracoxib, LY-518674; MDV-3100, MGCD-0103, Mirabegron, MyoCell; NASHA/Dx, Niacin/laropiprant; O6-Benzylguanine, Ocrelizumab, Olmesartan medoxomil, Omalizumab; P-276-00, Paclitaxel nanoparticles, Paclitaxel nanoparticles, Padoporfin, Paliperidone, PAN-811, Pegaptanib octasodium, Pegfilgrastim, Pemetrexed disodium, PF-00299804, Pimecrolimus, Prasugrel, Pregabalin; Reolysin, Rimonabant, Rivaroxaban, Rosuvastatin calcium; Satraplatin, SCH-697243,Selenite sodium, Silodosin, Sorafenib, Sunitinib malate; Talarozole, Taxus, Temsirolimus, Tocilizumab, Tolevamer potassium sodium, Tremelimumab, TTP-889; Uracil; V-260, Valsartan/amlodipine besylate, Vardenafil hydrochloride hydrate, Varenicline tartrate, Varespladib, Vitespen, Voclosporin, VX-001; Xience V; Zotarolimus-eluting stent.

Gene_expression (intravenous) of Immunoglobulin in Fibroblast associated with pregabalin, influenza in birds, abatacept, hepatitis b virus infection, adalimumab and duloxetine
20) Confidence 0.09 Published 2008 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 18806898 Disease Relevance 0.20 Pain Relevance 0.25

General Comments

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