INT11180

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Context Info
Confidence 0.46
First Reported 1982
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 52
Total Number 54
Disease Relevance 13.86
Pain Relevance 42.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 4
plasma 1
hepatocytes 1
colon 1
common bile duct 1
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 663 100.00 Very High Very High Very High
Bile 15 100.00 Very High Very High Very High
palliative 1 96.04 Very High Very High Very High
Inflammation 1 95.52 Very High Very High Very High
Analgesic 6 90.52 High High
addiction 1 89.44 High High
anesthesia 2 83.48 Quite High
Glutamate 1 61.00 Quite High
Osteoarthritis 2 50.00 Quite Low
Dextromethorphan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Overdose 11 99.96 Very High Very High Very High
Hepatotoxicity 45 99.92 Very High Very High Very High
Toxicity 21 99.64 Very High Very High Very High
Anaemia 1 99.54 Very High Very High Very High
Necrosis 21 99.36 Very High Very High Very High
Nephrotoxicity 46 99.00 Very High Very High Very High
Fever 2 98.52 Very High Very High Very High
Rheumatoid Arthritis 10 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The covalent binding of APAP to the hepatocytes increased with APAP concentration up to 50 mM without loss of cell viability.
APAP Binding (binding) of in hepatocytes associated with paracetamol
1) Confidence 0.46 Published 1998 Journal J Pharm Sci Section Abstract Doc Link 9572917 Disease Relevance 0.25 Pain Relevance 1.23
Prompt recognition of APAP overdose and institution of appropriate therapy are essential to preventing morbidity and mortality.
APAP Binding (recognition) of associated with overdose
2) Confidence 0.34 Published 2006 Journal Clin. Lab. Med. Section Abstract Doc Link 16567225 Disease Relevance 0.27 Pain Relevance 0.25
Castration also reduced the level of selective covalent binding of APAP metabolites to renal proteins as detected on Western blots with affinity-purified anti-APAP antibodies.
APAP Binding (binding) of associated with paracetamol
3) Confidence 0.34 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.38 Pain Relevance 1.39
The appearance of a small amount of glutathione conjugate in urine (16%) after an iv dose of the cysteine conjugate indicates that formation of the glutathione of APAP can occur by a route that does not involve direct conjugation of reactive metabolites of the drug with glutathione.
APAP Binding (formation) of in urine associated with paracetamol
4) Confidence 0.34 Published 1985 Journal Drug Metab. Dispos. Section Abstract Doc Link 2859156 Disease Relevance 0 Pain Relevance 0.54
Covalent binding of [3H]APAP-related material to hepatic macromolecules in RA-pretreated animals was similar to APAP alone values up to 12 hr after treatment; however, 24 hr after APAP, binding in the RA-pretreated animals was twice that observed in animals given [3H]APAP alone.
APAP Binding (binding) of associated with paracetamol and rheumatoid arthritis
5) Confidence 0.30 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3133464 Disease Relevance 0.70 Pain Relevance 1.37
Castration also did not alter APAP covalent binding in liver or APAP hepatotoxicity.
APAP Binding (binding) of in liver associated with paracetamol and hepatotoxicity
6) Confidence 0.30 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.40 Pain Relevance 1.29
The urinary excretion of cysteine and mercapturic acid conjugates was not altered, however, by ligation of the common bile duct in mice given APAP.
APAP Neg (not) Binding (ligation) of in common bile duct associated with paracetamol and bile
7) Confidence 0.30 Published 1985 Journal Drug Metab. Dispos. Section Abstract Doc Link 2859156 Disease Relevance 0 Pain Relevance 0.82
This lesion may result from the covalent binding of reactive intermediates of APAP to cellular macromolecules when glutathione (GSH) is sufficiently depleted.
APAP Binding (binding) of associated with paracetamol
8) Confidence 0.30 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6278138 Disease Relevance 0.10 Pain Relevance 0.66
APAP binding peaked at 3 hr and did not decrease significantly thereafter.
APAP Binding (binding) of associated with paracetamol
9) Confidence 0.30 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981734 Disease Relevance 0 Pain Relevance 0.76
Both APAP and caffeine were found to bind at the active site in proximity to the heme iron.
APAP Binding (bind) of
10) Confidence 0.29 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17894464 Disease Relevance 0 Pain Relevance 0.21
The formation of the APAP adducts could be inhibited by the same agents which prevent APAP cytotoxicity.
APAP Binding (formation) of associated with paracetamol
11) Confidence 0.28 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791125 Disease Relevance 0.21 Pain Relevance 1.20
METHODS: Four hundred and three adult patients with moderate pain secondary to knee OA were randomized to receive APAP ER 1300 mg three times daily, rofecoxib 12.5mg once daily, or rofecoxib 25mg once daily.
APAP Binding (receive) of in knee
12) Confidence 0.27 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 18640856 Disease Relevance 0.19 Pain Relevance 0
AOAPS and APAPS competitively displaced the serum protein binding of APAP, while AMAPS had little effect.
APAP Binding (binding) of associated with paracetamol
13) Confidence 0.25 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9178933 Disease Relevance 0 Pain Relevance 1.13
It is generally accepted that N-acetyl-p-benzoquinone imine (NAPQI) is the toxic, reactive intermediate whose formation from APAP is mediated by cytochrome P450.
APAP Binding (formation) of associated with paracetamol
14) Confidence 0.22 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 11095574 Disease Relevance 0.09 Pain Relevance 0.80
The chicken anemia virus-derived protein apoptin induces apoptosis in a wide range of human tumor cells and is not hindered by mutations inactivating p53 or by overexpression of Bcl-2, changes known to frustrate chemotherapy and radiation therapy.
apoptin Binding (hindered) of associated with anaemia, cancer and apoptosis
15) Confidence 0.22 Published 2004 Journal J. Mol. Med. Section Abstract Doc Link 14647920 Disease Relevance 1.02 Pain Relevance 0.10
A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study.
APAP Binding (interaction) of associated with paracetamol
16) Confidence 0.20 Published 2007 Journal Arch. Pharm. Res. Section Abstract Doc Link 18254252 Disease Relevance 0.10 Pain Relevance 0.70
Interestingly, covalent binding of 14C-labeled APAP to liver target proteins; arylation of APAP to 58, 56, and 44 kDa acetaminophen binding proteins (ABPs); and glutathione (GSH) depletion in the liver did not differ between nondiabetic (non-DB) and DB mice in spite of downregulated hepatic microsomal CYP2E1 and 1A2 proteins in the DB mice, known to be involved in bioactivation of APAP.
APAP Binding (binding) of in liver associated with paracetamol and diabetes mellitus
17) Confidence 0.16 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12700423 Disease Relevance 0.98 Pain Relevance 1.03
However, covalent binding of [ring-14C]APAP to renal and hepatic microsomal protein in vitro was similar for both SD and F344 rats.
APAP Binding (binding) of associated with paracetamol
18) Confidence 0.13 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6868091 Disease Relevance 0.60 Pain Relevance 1.01
Immunochemical analysis of kidneys from APAP-treated mice demonstrated covalently bound APAP but no binding was detected after mice were treated with a nephrotoxic dose of PAP.
APAP Neg (no) Binding (binding) of associated with paracetamol
19) Confidence 0.13 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.65 Pain Relevance 1.06
Immunochemical analysis of kidneys from APAP-treated mice demonstrated covalently bound APAP but no binding was detected after mice were treated with a nephrotoxic dose of PAP.
APAP Binding (bound) of associated with paracetamol
20) Confidence 0.13 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.65 Pain Relevance 1.05

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