INT111807

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.10
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
erythrocyte 1
heart 1
Hk (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 8 99.98 Very High Very High Very High
ischemia 114 98.12 Very High Very High Very High
anesthesia 11 93.56 High High
imagery 18 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 42 100.00 Very High Very High Very High
Cv Unclassified Under Development 111 98.12 Very High Very High Very High
Targeted Disruption 18 97.48 Very High Very High Very High
Reperfusion Injury 21 95.00 High High
Decapitation 2 92.64 High High
Coronary Artery Disease 3 89.72 High High
Body Weight 9 62.04 Quite High
Injury 54 43.00 Quite Low
Hyperemia 3 11.76 Low Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That HK protects against cell death instigated by ischemia–reperfusion in the male animal, extends our previous findings [10, 30] on the association of increased mitochondrial HK with ischemic preconditioning in the isolated male rat heart towards a more causal role of HK as one of the determinants of reperfusion injury in vivo, at least for the male animal.
Positive_regulation (increased) of HK in heart associated with reperfusion injury, ischemia and death
1) Confidence 0.37 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.88 Pain Relevance 0.17
Overexpressing HKII resulted in a robust increase in HK activity (360% for male and 480% for female).
Positive_regulation (increase) of HK
2) Confidence 0.27 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.42 Pain Relevance 0
In vivo interventions that specifically target mitochondrial HK will be necessary to further elucidate whether the increased cell death with diminished cellular HK can be completely ascribed to the decrease in mitochondrial HK.
Positive_regulation (increased) of HK associated with death
3) Confidence 0.27 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.63 Pain Relevance 0.09
A dose of 5 mg kg(-1) of lidocaine activated the rat HK activity by 41% (p < 0.001), 22% (p < 0.001), and 11% (p < 0.05), at 1.5, 3 and 6 h, respectively.
Positive_regulation (activated) of HK associated with lidocaine
4) Confidence 0.27 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866723 Disease Relevance 0 Pain Relevance 0.32
On the other hand, human erythrocyte HK was inhibited by theophylline, but activated by lidocaine.
Positive_regulation (activated) of HK in erythrocyte associated with lidocaine
5) Confidence 0.18 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866723 Disease Relevance 0 Pain Relevance 0.34
The n-3 PUFA caused increases in the activities of HK, G6PD, LDH, and MDH in comparison with control.
Positive_regulation (increases) of HK
6) Confidence 0.04 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15207530 Disease Relevance 0.09 Pain Relevance 0.09
As a result, n-3 PUFA may regulate the metabolic function of liver effectively by increasing HK, G6PD, 6PGD, LDH, and MDH enzyme activities of rat liver when added in enough amounts to the regular diet.
Positive_regulation (increasing) of HK in liver
7) Confidence 0.03 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15207530 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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