INT111808

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 5.18
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle tissue 1
erythrocyte 1
muscle 1
Hk (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 8 98.60 Very High Very High Very High
ischemia 304 85.88 High High
Calcium channel 8 78.32 Quite High
Inflammation 8 71.16 Quite High
imagery 48 5.00 Very Low Very Low Very Low
anesthesia 24 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
Sciatic nerve 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 144 99.68 Very High Very High Very High
Targeted Disruption 48 99.32 Very High Very High Very High
Death 112 98.74 Very High Very High Very High
Reperfusion Injury 56 96.40 Very High Very High Very High
Shock 8 91.92 High High
Cv Unclassified Under Development 296 85.88 High High
Coronary Artery Disease 8 79.36 Quite High
Body Weight 24 75.80 Quite High
INFLAMMATION 8 71.16 Quite High
Stress 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it should be noted that, in our study, we cannot distinguish between decreased cytosolic HK or decreased mitochondrial HK because HK is diminished in both cellular compartments in the HK+/- animal.
Negative_regulation (diminished) of HK
1) Confidence 0.32 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.73 Pain Relevance 0.13
The partial knockout for HKII resulted in 44% and 47% reduction in HK activity relative to wild-type animals, for male and female mice, respectively.
Negative_regulation (reduction) of HK associated with targeted disruption
2) Confidence 0.32 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.39 Pain Relevance 0
It is also in support of recent data showing that decreasing the amount of HK bound to mitochondria results in increased cell death in cellular studies.
Negative_regulation (decreasing) of HK associated with death
3) Confidence 0.27 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.79 Pain Relevance 0.15
However, it should be noted that, in our study, we cannot distinguish between decreased cytosolic HK or decreased mitochondrial HK because HK is diminished in both cellular compartments in the HK+/- animal.
Negative_regulation (decreased) of HK
4) Confidence 0.23 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.74 Pain Relevance 0.13
It is possible that the reduced HK resulted in reduced glucose uptake [8] and thus reduced glycolysis during muscle contraction.
Spec (possible) Negative_regulation (reduced) of HK in muscle
5) Confidence 0.23 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.33 Pain Relevance 0.03
In vivo interventions that specifically target mitochondrial HK will be necessary to further elucidate whether the increased cell death with diminished cellular HK can be completely ascribed to the decrease in mitochondrial HK.
Negative_regulation (decrease) of HK associated with death
6) Confidence 0.23 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.55 Pain Relevance 0.06
Thus, it seems that female hormones endorse muscle tissue with an increased natural protection against I/R injury, possibly also preventing the HK-deficiency induced injury in the current, mild, skeletal muscle I/R model in the female mice.
Spec (possibly) Negative_regulation (preventing) of HK in muscle tissue associated with injury
7) Confidence 0.23 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.91 Pain Relevance 0.17
However, it should be noted that, in our study, we cannot distinguish between decreased cytosolic HK or decreased mitochondrial HK because HK is diminished in both cellular compartments in the HK+/- animal.
Negative_regulation (decreased) of HK
8) Confidence 0.23 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.74 Pain Relevance 0.13
In the case of in vivo studies, 6 mg kg(-1) of theophylline inhibited the rat HK activity by 43% at the first 1.5 h (p < 0.001).
Negative_regulation (inhibited) of HK
9) Confidence 0.23 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866723 Disease Relevance 0 Pain Relevance 0.33
On the other hand, human erythrocyte HK was inhibited by theophylline, but activated by lidocaine.
Negative_regulation (inhibited) of HK in erythrocyte associated with lidocaine
10) Confidence 0.17 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866723 Disease Relevance 0 Pain Relevance 0.33

General Comments

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