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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.30

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signal transduction (CREM, CRH) cell differentiation (CREM) extracellular space (CRH)
extracellular region (CRH) nucleus (CREM) DNA binding (CREM)
CREM (Homo sapiens)
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 98.64 Very High Very High Very High
Kinase C 1 98.48 Very High Very High Very High
antidepressant 2 82.48 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forskolin (an activator of adenylate cyclase), but not phorbol 12-myristate 13-acetate (an activator of protein kinase C), ca. 3-fold increased reporter gene activity, which confirms the critical role of the cAMP-responsive element in regulation of the CRH gene.
cAMP-responsive element Regulation (role) of Regulation (regulation) of CRH gene associated with kinase c
1) Confidence 0.12 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.30

General Comments

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