INT111820

Context Info Confidence 0.42 First Reported 2003 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 10 Total Number 11 Disease Relevance 10.63 Pain Relevance 3.01

mitochondrion (Fdps) nucleolus (Fdps) peroxisome (Fdps) nucleus (Fdps) cytoplasm (Fdps)

Fdps (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 43 100.00 cva 48 99.56 Inflammation 20 99.02 Mcgill questionnaire 1 95.68 Hyperalgesia 10 93.52 dorsal root ganglion 2 91.04 Inflammatory mediators 2 87.00 cytokine 4 84.36 bradykinin 4 83.80 Central nervous system 6 61.92

Disease Link Frequency Relevance Heat Pain 45 100.00 Disease 115 99.68 Cv General 3 Under Development 4 99.56 Chronic Disease 15 99.12 INFLAMMATION 22 99.02 Disseminated Intravascular Coagulation 152 98.96 Injury 20 98.42 Toxicity 4 97.76 Hyperalgesia 12 93.52 Ganglion Cysts 2 91.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In order to accommodate FPs' schedules, three of the five interviews were held in the early evening, and two in the morning.

Positive_regulation (accommodate) of FPs

1) Confidence 0.42 Published 2004 Journal BMC Fam Pract Section Body Doc Link PMC535864 Disease Relevance 0.20 Pain Relevance 0

The FPs were much more involved and updated concerning the medical care of these patients.

Positive_regulation (updated) of FPs

2) Confidence 0.23 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0 Pain Relevance 0

Insufficient time or routines at the HC and organisational boundaries were working conditions that could prevent FPs from retaining the initiative.

Positive_regulation (prevent) of FPs

3) Confidence 0.23 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.34 Pain Relevance 0.05

Consultants rely on DNs to arrange future FP visits for both acute conditions and chronic diseases and to manage some diseases independently, contacting the FPs when necessary.

Positive_regulation (contacting) of FPs associated with disease and chronic disease

4) Confidence 0.23 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.20 Pain Relevance 0

Results showed a significant increase in the scores on the CAS for Pain Affect and the FPS in the demented patients compared to the control group.

Positive_regulation (increase) of FPS associated with pain

5) Confidence 0.19 Published 2003 Journal Psychiatry Section Abstract Doc Link 12868293 Disease Relevance 1.81 Pain Relevance 1.20

Activation of GPR92/LPA5 by FPP increases IP production, cAMP levels, and Ca2+ levels in a concentration-dependent manner.

Positive_regulation (increases) of FPP

6) Confidence 0.18 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.74 Pain Relevance 0.63

A report by Yin and colleagues [24] states that FPP was not effective in recruiting beta arrestin in a GPR92 expression system.

Neg (not) Positive_regulation (effective) of FPP

7) Confidence 0.15 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.55 Pain Relevance 0.48

FDPs, which serve as a marker of plasmin activation, are elevated in 85–100% patients with DIC, but the specificity of high levels of FDPs is limited and many other conditions, such as trauma, recent surgery, inflammation or venous thrombo-embolism, are associated with elevated FDPs.

Positive_regulation (elevated) of FDPs associated with inflammation, injury, disseminated intravascular coagulation and cva

8) Confidence 0.13 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.65 Pain Relevance 0.23

Therefore, it is not surprising that the elevated levels of D-dimer and FDPs in the model guinea pigs may reflect the hematological toxicity of the leptospiral LPS, but not strong enough to cause any detectable DIC.

Positive_regulation (elevated) of FDPs associated with toxicity and disseminated intravascular coagulation

9) Confidence 0.10 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.55 Pain Relevance 0

FDPs, which serve as a marker of plasmin activation, are elevated in 85–100% patients with DIC, but the specificity of high levels of FDPs is limited and many other conditions, such as trauma, recent surgery, inflammation or venous thrombo-embolism, are associated with elevated FDPs.

Positive_regulation (activation) of FDPs associated with inflammation, injury, disseminated intravascular coagulation and cva

10) Confidence 0.09 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.79 Pain Relevance 0.21

FDPs, which serve as a marker of plasmin activation, are elevated in 85–100% patients with DIC, but the specificity of high levels of FDPs is limited and many other conditions, such as trauma, recent surgery, inflammation or venous thrombo-embolism, are associated with elevated FDPs.

Positive_regulation (elevated) of FDPs associated with inflammation, injury, disseminated intravascular coagulation and cva

11) Confidence 0.09 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.80 Pain Relevance 0.21

General Comments

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