INT111822

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.61
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt8) nucleus (Krt8) cytoplasm (Krt8)
Anatomy Link Frequency
liver 3
Krt8 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 33 99.52 Very High Very High Very High
Chronic pancreatitis 1 99.20 Very High Very High Very High
Potency 4 90.28 High High
Inflammation 13 83.68 Quite High
COX2 1 46.04 Quite Low
Paracetamol 16 37.76 Quite Low
cytokine 9 26.92 Quite Low
alcohol 15 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Liver Failure 36 99.88 Very High Very High Very High
Cirrhosis 32 99.76 Very High Very High Very High
Liver Disease 60 99.60 Very High Very High Very High
Apoptosis 92 99.52 Very High Very High Very High
Pancreatitis 1 99.20 Very High Very High Very High
Chronic Hepatitis 16 98.00 Very High Very High Very High
Targeted Disruption 57 91.08 High High
Cleidocranial Dysplasia 1 87.08 High High
Gliosis 4 80.76 Quite High
Disease 70 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of keratin 8 gene mutation with chronic pancreatitis.
keratin 8 Binding (Association) of associated with chronic pancreatitis
1) Confidence 0.34 Published 2003 Journal Dig Liver Dis Section Title Doc Link 12868678 Disease Relevance 0.28 Pain Relevance 0.18
K8/K18 variants also associate with development of liver fibrosis in patients with chronic hepatitis C.
K8 Binding (associate) of in liver associated with fibrosis, chronic hepatitis and cirrhosis
2) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 1.06 Pain Relevance 0.05
Furthermore, K8/K18 variants associate with liver fibrosis progression in patients with chronic hepatitis C (Strnad et al. 2006).
K8 Binding (associate) of in liver associated with fibrosis, chronic hepatitis and cirrhosis
3) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.90 Pain Relevance 0.08
K8/K18 bind to several apoptotic proteins and type I keratins are established caspase substrates (Oshima 2002; Green et al. 2005; Marceau et al. 2007).
K8 Binding (bind) of associated with apoptosis
4) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.09 Pain Relevance 0
Several K8/K18 variants were found to associate with the development of cryptogenic liver disease (Ku et al. 2001).
K8 Binding (associate) of in liver associated with liver disease
5) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.99 Pain Relevance 0.07
Other signatures of up-regulated genes in USC-HN1 cells include ATP5H, HSP27, FABP5, E-cadherin, EIF4G2, KRT18 and KRT8, RPLP0 and RPS18, which are associated with various biological processes such as cell growth and maintenance, cell cycle regulation, metabolism, and protein translation and synthesis (Table 4).


KRT8 Binding (associated) of
6) Confidence 0.11 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.28 Pain Relevance 0

General Comments

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