INT111828

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Context Info
Confidence 0.00
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPB1) signal transduction (Oprm1) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (UPB1)
small molecule metabolic process (UPB1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
DRG 1
UPB1 (Homo sapiens)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 11 100.00 Very High Very High Very High
agonist 5 99.74 Very High Very High Very High
Inflammation 11 99.22 Very High Very High Very High
Buprenorphine 1 97.16 Very High Very High Very High
antinociception 1 86.24 High High
Pain 3 75.00 Quite High
opioid receptor 1 75.00 Quite High
Opioid 3 63.84 Quite High
Arthritis 1 57.16 Quite High
Analgesic 2 53.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.22 Very High Very High Very High
Nociception 1 81.88 Quite High
Arthritis 1 57.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The partial agonist buprenorphine hydrochloride (BUP) showed no detectable G-protein coupling in DRG of animals without FCA inflammation; however, partial agonist activity of BUP-induced MOR G-protein coupling was detectable in animals with FCA inflammation (EC50 = 1.6 nM; relative Emax = 82%).
BUP Positive_regulation (induced) of MOR in DRG associated with inflammation, mu opioid receptor, agonist and buprenorphine
1) Confidence 0.00 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12869624 Disease Relevance 0.85 Pain Relevance 1.53

General Comments

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